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Articles

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann

Biochem Soc Trans (2022) 50 (5): 1377–1388.

https://doi.org/10.1042/BST20220446

Published: 06 September 2022

... restoration of blood flow is necessary to save brain tissue, it also causes reperfusion injury. Mitochondria play a crucial role in early ischemia-reperfusion injury due to the generation of reactive oxygen species (ROS). During ischemia, mitochondria sense energy depletion and futilely attempt to up-regulate...

View article titled, Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Articles

Controlled power: how biology manages succinate-driven energy release

Shona A. Mookerjee, Akos A. Gerencser, Mark A. Watson, Martin D. Brand

Biochem Soc Trans (2021) 49 (6): 2929–2939.

https://doi.org/10.1042/BST20211032

Published: 09 December 2021

... that overcome these constraints and allow succinate oxidation to drive pmf too high can cause pathological generation of reactive oxygen species. We discuss the thermodynamic properties that allow succinate oxidation to drive pmf higher than NADH oxidation, and discuss the evidence for kinetic tuning of ATP...

View article titled, Controlled power: how biology manages succinate-driven energy release

Articles

Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors

Asal Ghaffari Zaki, Yusuf C. Erdoğan, Tuba Akgul Caglar, Emrah Eroglu

Biochem Soc Trans (2022) 50 (1): 335–345.

https://doi.org/10.1042/BST20210506

Published: 11 January 2021

... of the engineered recombinant proteins ( Figure 2 ). Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS) and a critical intercellular and intracellular messenger molecule [ 1 , 2 ]. H 2 O 2 plays a plethora of critical roles in normal physiological responses in mammalian cells [ 3 ], tissues [ 4...

View article titled, Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors

Articles

Cross-talk between redox signalling and protein aggregation

Loes van Dam, Tobias B. Dansen

Biochem Soc Trans (2020) 48 (2): 379–397.

https://doi.org/10.1042/BST20190054

Published: 20 April 2020

...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...

View article titled, Cross-talk between redox signalling and protein aggregation

Articles

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Jia Jin Hiu, Michelle Khai Khun Yap

Biochem Soc Trans (2020) 48 (2): 719–731.

https://doi.org/10.1042/BST20200110

Published: 08 April 2020

.... It is proposed that PLA 2 and LAAO contribute to an elevated oxidative stress due to their catalytic actions, for instance, the ability of PLA 2 to produce reactive oxygen species during lipolysis and formation of H 2 O 2 from LAAO catalytic activity which consequently lead to cell death. Nonetheless, the cell...

View article titled, Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Articles

Cellular mechanisms of complex I-associated pathology

Andrey Y. Abramov, Plamena R. Angelova

Biochem Soc Trans (2019) 47 (6): 1963–1969.

https://doi.org/10.1042/BST20191042

Published: 26 November 2019

... and -independent production of reactive oxygen species by rat brain mitochondria . J. Neurochem. 79 , 266 – 277 10.1046/j.1471-4159.2001.00548.x 5 Angelova , P.R. and Abramov , A.Y. ( 2016 ) Functional role of mitochondrial reactive oxygen species in physiology . Free Radic. Biol. Med...

View article titled, Cellular mechanisms of complex I-associated pathology

Articles

The double-edged role of neutrophil extracellular traps in inflammation

Maximilien Euler, Markus H. Hoffmann

Biochem Soc Trans (2019) 47 (6): 1921–1930.

https://doi.org/10.1042/BST20190629

Published: 22 November 2019

...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 aminoferrocene gout inflammation neutrophil neutrophil extracellular traps reactive oxygen species Correspondence: Markus H. Hoffmann ( markus.hoffmann@uk-erlangen.de ) 16 10 2019 31 10 2019 1...

View article titled, The double-edged role of neutrophil extracellular traps in inflammation

Articles

Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes

Mark A. Watson, Hoi-Shan Wong, Martin D. Brand

Biochem Soc Trans (2019) 47 (5): 1461–1469.

https://doi.org/10.1042/BST20190305

Published: 10 September 2019

... mitochondria mitochondrial dysfunction reactive oxygen species superoxide There is an ever-increasing literature that associates mitochondrial reactive oxygen species (ROS) in either a causal or correlative manner to almost any pathology [ 1 – 5 ]. Long before mitochondria were shown to generate...

View article titled, Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes

Articles

Coenzyme A: a protective thiol in bacterial antioxidant defence

Ivan Gout

Biochem Soc Trans (2019) 47 (1): 469–476.

https://doi.org/10.1042/BST20180415

Published: 19 February 2019

... of the Biochemical Society 2019 coenzyme A low-molecular-weight thiols post-translational modification protein CoAlation reactive oxygen species redox regulation in bacteria Bacteria are adapted to grow and survive in enormously diverse conditions under aerobic or anaerobic environments. Obligate...

View article titled, Coenzyme A: a protective thiol in bacterial antioxidant defence

Articles

Vitamin D: a custodian of cell signalling stability in health and disease

Michael J. Berridge

Biochem Soc Trans (2015) 43 (3): 349–358.

https://doi.org/10.1042/BST20140279

Published: 01 June 2015

... to depend on its role as a guardian of phenotypic stability particularly with regard to the reactive oxygen species (ROS) and Ca 2+ signalling systems. Vitamin D maintains the expression of those signalling components responsible for stabilizing the low-resting state of these two signalling pathways...

View article titled, Vitamin D: a custodian of cell signalling stability in health and disease

Articles

Ultra-endurance exercise: unanswered questions in redox biology and immunology

James E. Turner, Stuart J. Bennett, Jos A. Bosch, Helen R. Griffiths, Sarah Aldred

Biochem Soc Trans (2014) 42 (4): 989–995.

https://doi.org/10.1042/BST20140120

Published: 11 August 2014

... that repeated extreme exercise events could have deleterious effects on health, which might be brought about by the high levels of ROS (reactive oxygen species) produced during exercise. Studies that have examined biomarkers of oxidative damage following ultra-endurance exercise have found measurements...

View article titled, Ultra-endurance exercise: unanswered questions in redox biology and immunology

Articles

Manganese superoxide dismutase in carcinogenesis: friend or foe?

Anja Konzack, Thomas Kietzmann

Biochem Soc Trans (2014) 42 (4): 1012–1016.

https://doi.org/10.1042/BST20140076

Published: 11 August 2014

...Anja Konzack; Thomas Kietzmann Superoxide and its derived ROS (reactive oxygen species) have been considered for a long time to be generated as toxic by-products of metabolic events. Although ROS generated in low amounts are able to act as signalling molecules, ROS appear to also play a major role...

View article titled, Manganese superoxide dismutase in carcinogenesis: friend or foe?

Articles

Tadpole tail regeneration in Xenopus

Yaoyao Chen, Nick R. Love, Enrique Amaya

Biochem Soc Trans (2014) 42 (3): 617–623.

https://doi.org/10.1042/BST20140061

Published: 22 May 2014

... be addressed (email enrique.amaya@manchester.ac.uk ). 14 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 metabolism reactive oxygen species tissue regeneration wound healing Xenopus Although mammals have relatively poor capacities to heal wounds...

View article titled, Tadpole tail regeneration in Xenopus

Articles

Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria

Ruben Quintana-Cabrera, Juan P. Bolaños

Biochem Soc Trans (2013) 41 (1): 106–110.

https://doi.org/10.1042/BST20120252

Published: 29 January 2013

...Ruben Quintana-Cabrera; Juan P. Bolaños Mitochondria are both the main producers and targets of ROS (reactive oxygen species). Among the battery of antioxidants that protect mitochondria from ROS, GSH is thought to be essential for the organelle antioxidant function. However, mitochondria cannot...

View article titled, Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria

Articles

Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina

Heinz D. Osiewacz

Biochem Soc Trans (2011) 39 (5): 1488–1492.

https://doi.org/10.1042/BST0391488

Published: 21 September 2011

... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...

View article titled, Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina

Articles

Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species

Wei Zhuo, Xiaomin Song, Hao Zhou, Yongzhang Luo

Biochem Soc Trans (2011) 39 (5): 1376–1381.

https://doi.org/10.1042/BST0391376

Published: 21 September 2011

... of endothelial tip cells. By arginine depletion, ADI disturbs actin filament in endothelial tip cells, causing disordered migratory direction and decreased migration ability. Furthermore, ADI induces excessive synthesis of ROS (reactive oxygen species), and activates caspase 8-, but not caspase 9-, dependent...

View article titled, Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species

Includes: Supplementary data

Articles

Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease

David Allsop, Jennifer Mayes, Susan Moore, Atef Masad, Brian J. Tabner

Biochem Soc Trans (2008) 36 (6): 1293–1298.

https://doi.org/10.1042/BST0361293

Published: 19 November 2008

... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...

View article titled, Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease

Articles

Oxidative stress: the vulnerable β-cell

Sigurd Lenzen

Biochem Soc Trans (2008) 36 (3): 343–347.

https://doi.org/10.1042/BST0360343

Published: 21 May 2008

..., DNA damage and interference of reactive species with signal transduction pathways, which contribute significantly to β-cell dysfunction and death in Type 1 and Type 2 diabetes mellitus. Reactive oxygen species, superoxide radicals (O 2 •− ), hydrogen peroxide (H 2 O 2 ) and, in a final iron-catalysed...

View article titled, Oxidative stress: the vulnerable β-cell

Articles

P2X 7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

J. Hewinson, A.B. MacKenzie

Biochem Soc Trans (2007) 35 (5): 1168–1170.

https://doi.org/10.1042/BST0351168

Published: 25 October 2007

... nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular ATP activates a class of cell-surface nucleotide receptors...

View article titled, P2X 7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

Articles

Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

G.C. Brown

Biochem Soc Trans (2007) 35 (5): 1119–1121.

https://doi.org/10.1042/BST0351119

Published: 25 October 2007

... email gcb@mole.bio.cam.ac.uk 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell death inflammation nitric oxide peroxynitrite reactive nitrogen species reactive oxygen species Inflammatory neurodegeneration is neurodegeneration caused...

View article titled, Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

Articles

The roles of PKCδ and ϵ isoenzymes in the regulation of myocardial ischaemia/reperfusion injury

E.N. Churchill, D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1040–1042.

https://doi.org/10.1042/BST0351040

Published: 25 October 2007

...@stanford.edu ). 3 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis cardiac ischaemia/reperfusion injury ischaemic preconditioning proteasome protein kinase C (PKC) reactive oxygen species Cellular viability is determined by the balance of pro...

View article titled, The roles of PKCδ and ϵ isoenzymes in the regulation of myocardial ischaemia/reperfusion injury

Articles

The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs

P. Behe, A.W. Segal

Biochem Soc Trans (2007) 35 (5): 1100–1103.

https://doi.org/10.1042/BST0351100

Published: 25 October 2007

...P. Behe; A.W. Segal The NADPH oxidase of ‘professional’ phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. It is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through...

View article titled, The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs

Articles

Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications

C. Alarcón de la Lastra, I. Villegas

Biochem Soc Trans (2007) 35 (5): 1156–1160.

https://doi.org/10.1042/BST0351156

Published: 25 October 2007

... implications. 1 To whom correspondence should be addressed (email calarcon@us.es ). 24 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant copper DNA damage pro-oxidant reactive oxygen species resveratrol Resveratrol (3,4′,5...

View article titled, Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications

Articles

Chronic microglial activation and progressive dopaminergic neurotoxicity

M.L. Block, J.-S. Hong

Biochem Soc Trans (2007) 35 (5): 1127–1132.

https://doi.org/10.1042/BST0351127

Published: 25 October 2007

... diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently activated after a single stimulus and maintain the elevated production of both cytokines...

View article titled, Chronic microglial activation and progressive dopaminergic neurotoxicity

Articles

Dietary fats induce human monocyte activation in vitro

C. Bentley, F. Bejta, C. De Pascale, M. Avella, C.P.D. Wheeler-Jones, K.M. Botham, C. Lawson

Biochem Soc Trans (2007) 35 (3): 464–465.

https://doi.org/10.1042/BST0350464

Published: 22 May 2007

...-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte–CMR interactions may be important in early atherosclerosis when many activated monocytes are found...

View article titled, Dietary fats induce human monocyte activation in vitro

Articles

Oxidative stress and macrophage function: a failure to resolve the inflammatory response

P. Kirkham

Biochem Soc Trans (2007) 35 (2): 284–287.

https://doi.org/10.1042/BST0350284

Published: 20 March 2007

... chronic diseases [ 28 ]. 1 email paul.kirkham@novartis.com 25 9 2006 © 2007 The Biochemical Society 2007 chronic obstructive pulmonary disease (COPD) histone deacetylase (HDAC) inflammatory response macrophage oxidative stress reactive oxygen species In the last...

View article titled, Oxidative stress and macrophage function: a failure to resolve the inflammatory response

Articles

Metabolic switching of PI3K-dependent lipid signals

C.P. Downes, N.R. Leslie, I.H. Batty, J. van der Kaay

Biochem Soc Trans (2007) 35 (2): 188–192.

https://doi.org/10.1042/BST0350188

Published: 20 March 2007

... 10 (PTEN) phosphatidylinositol trisphosphate metabolism phosphorylation reactive oxygen species Src homology 2-containing inositol phosphatase-2 (SHIP2) PtdIns(3,4,5) P 3 and PtdIns(3,4) P 2 are two important lipid signals that have overlapping, but distinctive roles. Independent...

View article titled, Metabolic switching of PI3K-dependent lipid signals

Articles

Redox regulation of the ryanodine receptor/calcium release channel

S. Zissimopoulos, F.A. Lai

Biochem Soc Trans (2006) 34 (5): 919–921.

https://doi.org/10.1042/BST0340919

Published: 25 October 2006

... calcium signalling reactive oxygen species redox regulation ryanodine receptor sarcoplasmic reticulum thiol modification The RyR (ryanodine receptor) is an intracellular ion channel mediating Ca 2+ release from intracellular stores. Mammals express three RyR isoforms in both excitable and non...

View article titled, Redox regulation of the ryanodine receptor/calcium release channel

Articles

Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species

G.C. Brown, V. Borutaite

Biochem Soc Trans (2006) 34 (5): 953–956.

https://doi.org/10.1042/BST0340953

Published: 25 October 2006

...G.C. Brown; V. Borutaite ROS (reactive oxygen species) and RNS (reactive nitrogen species) are central to the innate immunity that protects us from infection, but also contribute to degenerative diseases and possibly aging. However, ROS and RNS are increasingly recognized to contribute...

View article titled, Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species

Articles

Redox signalling involving NADPH oxidase-derived reactive oxygen species

R. Dworakowski, N. Anilkumar, M. Zhang, A.M. Shah

Biochem Soc Trans (2006) 34 (5): 960–964.

https://doi.org/10.1042/BST0340960

Published: 25 October 2006

..., ROS (reactive oxygen species) also have signalling roles, acting as second messengers that modulate the activity of diverse intracellular signalling pathways and transcription factors, thereby inducing changes in cell phenotype. NADPH oxidases appear to be especially important sources of ROS involved...

View article titled, Redox signalling involving NADPH oxidase-derived reactive oxygen species

Articles

Regulation of insulin secretion by uncoupling protein

C.B. Chan, N. Kashemsant

Biochem Soc Trans (2006) 34 (5): 802–805.

https://doi.org/10.1042/BST0340802

Published: 25 October 2006

... in response to glucose. 1 To whom correspondence should be addressed (email cchan@upei.ca ). 15 6 2006 © 2006 The Biochemical Society 2006 fatty acid insulin secretion islet metabolism reactive oxygen species Type 2 diabetes uncoupling protein UCP2 (uncoupling...

View article titled, Regulation of insulin secretion by uncoupling protein

Articles

Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress

H. Freeman, K. Shimomura, R.D. Cox, F.M. Ashcroft

Biochem Soc Trans (2006) 34 (5): 806–810.

https://doi.org/10.1042/BST0340806

Published: 25 October 2006

...H. Freeman; K. Shimomura; R.D. Cox; F.M. Ashcroft This paper reviews recent studies on the role of Nnt (nicotinamide nucleotide transhydrogenase) in insulin secretion and detoxification of ROS (reactive oxygen species). Glucose-stimulated insulin release from pancreatic β-cells is mediated...

View article titled, Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress

Articles

Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation

D. Salvemini, T.M. Doyle, S. Cuzzocrea

Biochem Soc Trans (2006) 34 (5): 965–970.

https://doi.org/10.1042/BST0340965

Published: 25 October 2006

...D. Salvemini; T.M. Doyle; S. Cuzzocrea A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use...

View article titled, Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation

Articles

Disulphide formation on mitochondrial protein thiols

T.R. Hurd, A. Filipovska, N.J. Costa, C.C. Dahm, M.P. Murphy

Biochem Soc Trans (2005) 33 (6): 1390–1393.

https://doi.org/10.1042/BST0331390

Published: 26 October 2005

... of mitochondrial proteins are of particular importance. In the present study, we review the mechanisms and physiological significance of these processes. disulphide glutathione mitochondrion oxidative stress protein thiol reactive oxygen species There are a variety of mitochondrial PrSHs (protein...

View article titled, Disulphide formation on mitochondrial protein thiols

Articles

Nutrient sensing in pancreatic β cells suppresses mitochondrial superoxide generation and its contribution to apoptosis

G. Martens, Y. Cai, S. Hinke, G. Stangé, M. Van De Casteele, D. Pipeleers

Biochem Soc Trans (2005) 33 (1): 300–301.

https://doi.org/10.1042/BST0330300

Published: 01 February 2005

... rates of superoxide production in β cells with lower mitochondrial metabolic activity contributed to the susceptibility of these cells to apoptosis. apoptosis β cell glucose toxicity hyperglycaemia reactive oxygen species superoxide Chronic hyperglycaemia has been shown to cause diabetic...

View article titled, Nutrient sensing in pancreatic β cells suppresses mitochondrial superoxide generation and its contribution to apoptosis

Articles

Investigating mitochondrial radical production using targeted probes

M.P. Murphy

Biochem Soc Trans (2004) 32 (6): 1011–1014.

https://doi.org/10.1042/BST0321011

Published: 26 October 2004

... have targeted antioxidants, spin traps, thiol reagents and DNA-alkylating compounds to mitochondria. The selective mitochondrial localization of these compounds enables us to investigate several aspects of the production of reactive oxygen species by mitochondria. 1 Correspondence address...

View article titled, Investigating mitochondrial radical production using targeted probes

Articles

Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species

C.P. Downes, S. Walker, G. McConnachie, Y. Lindsay, I.H. Batty, N.R. Leslie

Biochem Soc Trans (2004) 32 (2): 338–342.

https://doi.org/10.1042/bst0320338

Published: 01 April 2004

... and by endogenously produced reactive oxygen species. This mechanism provides a novel means to stimulate phosphoinositide 3-kinase-dependent signalling pathways, which may be important in circumstances where PtdIns(3,4,5) P 3 and oxidants are produced concurrently. 338 Biochemical Society Transactions (2004) Volume...

View article titled, Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species

Articles

Possible role of free oxidation processes in the regulation of reactive oxygen species production in plant mitochondria

V.N. Popov

Biochem Soc Trans (2003) 31 (6): 1316–1317.

https://doi.org/10.1042/bst0311316

Published: 01 December 2003

... of reactive oxygen species. 1 e-mail pvn@main.vsu.ru 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 24 June 2003 © 2003 Biochemical Society 2003 alternative oxidase non-coupled respiration reactive oxygen species uncoupled...

View article titled, Possible role of free oxidation processes in the regulation of reactive oxygen species production in plant mitochondria

Articles

Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences

R.A.J. Smith, G.F. Kelso, F.H. Blaikie, C.M. Porteous, E.C. Ledgerwood, G. Hughes, A.M. James, M.F. Ross, J. Asin-Cayuela, H.M. Cochemé, A. Filipovska, M.P. Murphy

Biochem Soc Trans (2003) 31 (6): 1295–1299.

https://doi.org/10.1042/bst0311295

Published: 01 December 2003

...R.A.J. Smith; G.F. Kelso; F.H. Blaikie; C.M. Porteous; E.C. Ledgerwood; G. Hughes; A.M. James; M.F. Ross; J. Asin-Cayuela; H.M. Cochemé; A. Filipovska; M.P. Murphy The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain contributes to a range of pathologies, including...

View article titled, Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences

Articles

Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling

S. Miwa, M.D. Brand

Biochem Soc Trans (2003) 31 (6): 1300–1301.

https://doi.org/10.1042/bst0311300

Published: 01 December 2003

...S. Miwa; M.D. Brand Mitochondria produce ROS (reactive oxygen species) as a by-product of aerobic respiration. Several studies in mammals and birds suggest that the most physiologically relevant ROS production is from complex I following reverse electron flow, and is highly sensitive to membrane...

View article titled, Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling

Articles

Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan

J.N. Sampayo, M.S. Gill, G.J. Lithgow

Biochem Soc Trans (2003) 31 (6): 1305–1307.

https://doi.org/10.1042/bst0311305

Published: 01 December 2003

...-throughput screens for compounds that affect nematode survival in the face of acute oxidative stress and will facilitate the identification of novel drugs that extend nematode lifespan. Age genes aging Caenorhabditis elegans lifespan oxidative stress reactive oxygen species Abbreviations...

View article titled, Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan

Articles

Oxidant stress: a key determinant of atherothrombosis

J. Loscalzo

Biochem Soc Trans (2003) 31 (5): 1059–1061.

https://doi.org/10.1042/bst0311059

Published: 01 October 2003

...J. Loscalzo ROS (reactive oxygen species) are normal products of oxidative cellular metabolism. These biochemically active free-radical derivatives of molecular oxygen serve as normal signalling molecules in the vasculature; however, an excess of vascular ROS flux occurs in the setting of risk...

View article titled, Oxidant stress: a key determinant of atherothrombosis

Articles

The influence of iron homoeostasis on macrophage function

R. J. Ward, S. Wilmet, R. Legssyer, R. R. Crichton

Biochem Soc Trans (2002) 30 (4): 762–766.

https://doi.org/10.1042/bst0300762

Published: 01 August 2002

... and interferonγ, and an enhanced activation of nuclear factor k B in the absence of tumour necrosis factor α stimulation, and enhanced production of reactive oxygen species after activation with activated zymosan and PMA. Such results may indicate an imbalance in the production of reactive oxygen and reactive...

View article titled, The influence of iron homoeostasis on macrophage function

Articles

Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assay

A. R. Collins, E. Horváthová

Biochem Soc Trans (2001) 29 (2): 337–340.

https://doi.org/10.1042/bst0290337

Published: 01 May 2001

... DNA oxidation 8-oxoguanine reactive oxygen species strand breaks CHO, Chinese hamster ovary FPG, form midopyrimidine glycosylase Biochemical and Biomedical Aspects of Oxidative Mod if icat ion Irish Area Section Organized and Edited by R. J. H. Davies (School of Biology and Biochemistry...

View article titled, Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assay

Articles

Oxidative stress in cells exposed to low levels of ionizing radiation

F. M. Lyng, C. B. Seymour, C. Mothersill

Biochem Soc Trans (2001) 29 (2): 350–353.

https://doi.org/10.1042/bst0290350

Published: 01 May 2001

...F. M. Lyng; C. B. Seymour; C. Mothersill The ability of medium from γ-irradiated cells to induce early events in the apoptotic cascade, such as the mobilization of intracellular calcium, loss of mitochondrial membrane potential and increased levels of reactive oxygen species, in unirradiated cells...

View article titled, Oxidative stress in cells exposed to low levels of ionizing radiation

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