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Keywords: reactive oxygen species
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Biochem Soc Trans (2024) BST20231183.
Published: 25 March 2024
... transport system (ETS) composed of complexes I–IV. Due to its function, the ETS is the main source of reactive oxygen species (ROS), generating them on both sides of the mitochondrial inner membrane, i.e. the intermembrane space (IMS) and the matrix. A correct balance between ROS generation and scavenging...
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Biochem Soc Trans (2024) 52 (1): 65–74.
Published: 22 February 2024
...Opeyemi Stella Ademowo; Olubukola Oyebode; Roshita Edward; Myra E. Conway; Helen R. Griffiths; Irundika H.K. Dias Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS...
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Biochem Soc Trans (2023) 51 (6): 2071–2083.
Published: 13 December 2023
... 11 2023 24 11 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 Cancer CAP cold physical plasma reactive oxygen species ROS wound healing Physical plasma is a partially ionized gas and a multicomponent system...
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Biochem Soc Trans (2021) 49 (6): 2929–2939.
Published: 09 December 2021
... that overcome these constraints and allow succinate oxidation to drive pmf too high can cause pathological generation of reactive oxygen species. We discuss the thermodynamic properties that allow succinate oxidation to drive pmf higher than NADH oxidation, and discuss the evidence for kinetic tuning of ATP...
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Biochem Soc Trans (2022) 50 (1): 335–345.
Published: 11 January 2021
... new insights into the dynamics of compartmentalized H 2 O 2 , the transport mechanisms remain an open question. chemogenetics genetically encoded biosensors reactive nitrogen species reactive oxygen species signalling Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS...
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Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...
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Biochem Soc Trans (2020) 48 (2): 719–731.
Published: 08 April 2020
.... It is proposed that PLA 2 and LAAO contribute to an elevated oxidative stress due to their catalytic actions, for instance, the ability of PLA 2 to produce reactive oxygen species during lipolysis and formation of H 2 O 2 from LAAO catalytic activity which consequently lead to cell death. Nonetheless, the cell...
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Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
... and -independent production of reactive oxygen species by rat brain mitochondria . J. Neurochem. 79 , 266 – 277 10.1046/j.1471-4159.2001.00548.x 5 Angelova , P.R. and Abramov , A.Y. ( 2016 ) Functional role of mitochondrial reactive oxygen species in physiology . Free Radic. Biol. Med...
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Biochem Soc Trans (2019) 47 (6): 1921–1930.
Published: 22 November 2019
...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 aminoferrocene gout inflammation neutrophil neutrophil extracellular traps reactive oxygen species Correspondence: Markus H. Hoffmann ( markus.hoffmann@uk-erlangen.de ) 16 10 2019 31 10 2019 1...
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Biochem Soc Trans (2019) 47 (1): 469–476.
Published: 19 February 2019
... of the Biochemical Society 2019 coenzyme A low-molecular-weight thiols post-translational modification protein CoAlation reactive oxygen species redox regulation in bacteria Bacteria are adapted to grow and survive in enormously diverse conditions under aerobic or anaerobic environments. Obligate...
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Biochem Soc Trans (2015) 43 (3): 349–358.
Published: 01 June 2015
... to depend on its role as a guardian of phenotypic stability particularly with regard to the reactive oxygen species (ROS) and Ca 2+ signalling systems. Vitamin D maintains the expression of those signalling components responsible for stabilizing the low-resting state of these two signalling pathways...
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Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... that repeated extreme exercise events could have deleterious effects on health, which might be brought about by the high levels of ROS (reactive oxygen species) produced during exercise. Studies that have examined biomarkers of oxidative damage following ultra-endurance exercise have found measurements...
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Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
...Anja Konzack; Thomas Kietzmann Superoxide and its derived ROS (reactive oxygen species) have been considered for a long time to be generated as toxic by-products of metabolic events. Although ROS generated in low amounts are able to act as signalling molecules, ROS appear to also play a major role...
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Biochem Soc Trans (2014) 42 (3): 617–623.
Published: 22 May 2014
... be addressed (email enrique.amaya@manchester.ac.uk ). 14 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 metabolism reactive oxygen species tissue regeneration wound healing Xenopus Although mammals have relatively poor capacities to heal wounds...
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Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
...Ruben Quintana-Cabrera; Juan P. Bolaños Mitochondria are both the main producers and targets of ROS (reactive oxygen species). Among the battery of antioxidants that protect mitochondria from ROS, GSH is thought to be essential for the organelle antioxidant function. However, mitochondria cannot...
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Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
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Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., DNA damage and interference of reactive species with signal transduction pathways, which contribute significantly to β-cell dysfunction and death in Type 1 and Type 2 diabetes mellitus. Reactive oxygen species, superoxide radicals (O 2 •− ), hydrogen peroxide (H 2 O 2 ) and, in a final iron-catalysed...
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Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular ATP activates a class of cell-surface nucleotide receptors...
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Biochem Soc Trans (2007) 35 (5): 1119–1121.
Published: 25 October 2007
... email gcb@mole.bio.cam.ac.uk 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell death inflammation nitric oxide peroxynitrite reactive nitrogen species reactive oxygen species Inflammatory neurodegeneration is neurodegeneration caused...
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Biochem Soc Trans (2007) 35 (5): 1040–1042.
Published: 25 October 2007
...@stanford.edu ). 3 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis cardiac ischaemia/reperfusion injury ischaemic preconditioning proteasome protein kinase C (PKC) reactive oxygen species Cellular viability is determined by the balance of pro...
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Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
...P. Behe; A.W. Segal The NADPH oxidase of ‘professional’ phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. It is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through...
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Biochem Soc Trans (2007) 35 (5): 1156–1160.
Published: 25 October 2007
... implications. 1 To whom correspondence should be addressed (email calarcon@us.es ). 24 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant copper DNA damage pro-oxidant reactive oxygen species resveratrol Resveratrol (3,4′,5...
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Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
... diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently activated after a single stimulus and maintain the elevated production of both cytokines...
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Biochem Soc Trans (2007) 35 (3): 464–465.
Published: 22 May 2007
...-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte–CMR interactions may be important in early atherosclerosis when many activated monocytes are found...
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Biochem Soc Trans (2007) 35 (2): 284–287.
Published: 20 March 2007
... chronic diseases [ 28 ]. 1 email paul.kirkham@novartis.com 25 9 2006 © 2007 The Biochemical Society 2007 chronic obstructive pulmonary disease (COPD) histone deacetylase (HDAC) inflammatory response macrophage oxidative stress reactive oxygen species In the last...
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Biochem Soc Trans (2007) 35 (2): 188–192.
Published: 20 March 2007
... 10 (PTEN) phosphatidylinositol trisphosphate metabolism phosphorylation reactive oxygen species Src homology 2-containing inositol phosphatase-2 (SHIP2) PtdIns(3,4,5) P 3 and PtdIns(3,4) P 2 are two important lipid signals that have overlapping, but distinctive roles. Independent...
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Biochem Soc Trans (2006) 34 (5): 919–921.
Published: 25 October 2006
... calcium signalling reactive oxygen species redox regulation ryanodine receptor sarcoplasmic reticulum thiol modification The RyR (ryanodine receptor) is an intracellular ion channel mediating Ca 2+ release from intracellular stores. Mammals express three RyR isoforms in both excitable and non...
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Biochem Soc Trans (2006) 34 (5): 802–805.
Published: 25 October 2006
... in response to glucose. 1 To whom correspondence should be addressed (email cchan@upei.ca ). 15 6 2006 © 2006 The Biochemical Society 2006 fatty acid insulin secretion islet metabolism reactive oxygen species Type 2 diabetes uncoupling protein UCP2 (uncoupling...
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Biochem Soc Trans (2006) 34 (5): 806–810.
Published: 25 October 2006
...H. Freeman; K. Shimomura; R.D. Cox; F.M. Ashcroft This paper reviews recent studies on the role of Nnt (nicotinamide nucleotide transhydrogenase) in insulin secretion and detoxification of ROS (reactive oxygen species). Glucose-stimulated insulin release from pancreatic β-cells is mediated...
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Biochem Soc Trans (2006) 34 (5): 965–970.
Published: 25 October 2006
...D. Salvemini; T.M. Doyle; S. Cuzzocrea A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use...
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Biochem Soc Trans (2005) 33 (6): 1390–1393.
Published: 26 October 2005
... of mitochondrial proteins are of particular importance. In the present study, we review the mechanisms and physiological significance of these processes. disulphide glutathione mitochondrion oxidative stress protein thiol reactive oxygen species There are a variety of mitochondrial PrSHs (protein...
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Biochem Soc Trans (2005) 33 (1): 300–301.
Published: 01 February 2005
... rates of superoxide production in β cells with lower mitochondrial metabolic activity contributed to the susceptibility of these cells to apoptosis. apoptosis β cell glucose toxicity hyperglycaemia reactive oxygen species superoxide Chronic hyperglycaemia has been shown to cause diabetic...
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Biochem Soc Trans (2004) 32 (6): 1011–1014.
Published: 26 October 2004
... have targeted antioxidants, spin traps, thiol reagents and DNA-alkylating compounds to mitochondria. The selective mitochondrial localization of these compounds enables us to investigate several aspects of the production of reactive oxygen species by mitochondria. 1 Correspondence address...
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Biochem Soc Trans (2003) 31 (6): 1295–1299.
Published: 01 December 2003
...R.A.J. Smith; G.F. Kelso; F.H. Blaikie; C.M. Porteous; E.C. Ledgerwood; G. Hughes; A.M. James; M.F. Ross; J. Asin-Cayuela; H.M. Cochemé; A. Filipovska; M.P. Murphy The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain contributes to a range of pathologies, including...
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Biochem Soc Trans (2003) 31 (6): 1305–1307.
Published: 01 December 2003
...-throughput screens for compounds that affect nematode survival in the face of acute oxidative stress and will facilitate the identification of novel drugs that extend nematode lifespan. Age genes aging Caenorhabditis elegans lifespan oxidative stress reactive oxygen species Abbreviations...
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Biochem Soc Trans (2003) 31 (5): 1059–1061.
Published: 01 October 2003
...J. Loscalzo ROS (reactive oxygen species) are normal products of oxidative cellular metabolism. These biochemically active free-radical derivatives of molecular oxygen serve as normal signalling molecules in the vasculature; however, an excess of vascular ROS flux occurs in the setting of risk...
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Biochem Soc Trans (2002) 30 (4): 762–766.
Published: 01 August 2002
... and interferonγ, and an enhanced activation of nuclear factor k B in the absence of tumour necrosis factor α stimulation, and enhanced production of reactive oxygen species after activation with activated zymosan and PMA. Such results may indicate an imbalance in the production of reactive oxygen and reactive...
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Biochem Soc Trans (2001) 29 (2): 337–340.
Published: 01 May 2001
... DNA oxidation 8-oxoguanine reactive oxygen species strand breaks CHO, Chinese hamster ovary FPG, form midopyrimidine glycosylase Biochemical and Biomedical Aspects of Oxidative Mod if icat ion Irish Area Section Organized and Edited by R. J. H. Davies (School of Biology and Biochemistry...
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Biochem Soc Trans (2001) 29 (2): 350–353.
Published: 01 May 2001
...F. M. Lyng; C. B. Seymour; C. Mothersill The ability of medium from γ-irradiated cells to induce early events in the apoptotic cascade, such as the mobilization of intracellular calcium, loss of mitochondrial membrane potential and increased levels of reactive oxygen species, in unirradiated cells...