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Keywords: reactive oxygen species
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Biochem Soc Trans (2021) 49 (6): 2929–2939.
Published: 09 December 2021
... that overcome these constraints and allow succinate oxidation to drive pmf too high can cause pathological generation of reactive oxygen species. We discuss the thermodynamic properties that allow succinate oxidation to drive pmf higher than NADH oxidation, and discuss the evidence for kinetic tuning of ATP...
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Biochem Soc Trans (2022) 50 (1): 335–345.
Published: 11 January 2021
... of the Biochemical Society 2022 chemogenetics genetically encoded biosensors reactive nitrogen species reactive oxygen species signalling Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS) and a critical intercellular and intracellular messenger molecule [ 1 , 2 ]. H 2 O 2 plays...
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Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...
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Biochem Soc Trans (2020) 48 (2): 719–731.
Published: 08 April 2020
.... It is proposed that PLA 2 and LAAO contribute to an elevated oxidative stress due to their catalytic actions, for instance, the ability of PLA 2 to produce reactive oxygen species during lipolysis and formation of H 2 O 2 from LAAO catalytic activity which consequently lead to cell death. Nonetheless, the cell...
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Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
... of the Biochemical Society 2019 bioenergetics calcium complex I mitochondria reactive oxygen species Introduction Mitochondria are distinguishable from the other numerous cellular organelles by their functional importance, which includes control over energy metabolism, involvement in cell...
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Biochem Soc Trans (2019) 47 (6): 1921–1930.
Published: 22 November 2019
... extracellular traps (NETs). Initially described as a highly organized and reactive oxygen species (ROS)-dependent function of neutrophils directed against bacteria [ 1 , 2 ], the last 15 years have seen numerous studies that identified a plethora of other NET triggers, elucidated novel pathways of NET formation...
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Biochem Soc Trans (2019) 47 (1): 469–476.
Published: 19 February 2019
... allows protein thiols to maintain their reduced state. Bacteria actively employ LMW thiols as their intracellular redox buffer, and thiol–disulfide oxidoreductases to maintain a reduced state of the cytoplasm. To effectively detoxify different reactive oxygen species, LMW thiol-redox buffers are produced...
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Biochem Soc Trans (2015) 43 (3): 349–358.
Published: 01 June 2015
... to depend on its role as a guardian of phenotypic stability particularly with regard to the reactive oxygen species (ROS) and Ca 2+ signalling systems. Vitamin D maintains the expression of those signalling components responsible for stabilizing the low-resting state of these two signalling pathways...
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Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... that repeated extreme exercise events could have deleterious effects on health, which might be brought about by the high levels of ROS (reactive oxygen species) produced during exercise. Studies that have examined biomarkers of oxidative damage following ultra-endurance exercise have found measurements...
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Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
...Anja Konzack; Thomas Kietzmann Superoxide and its derived ROS (reactive oxygen species) have been considered for a long time to be generated as toxic by-products of metabolic events. Although ROS generated in low amounts are able to act as signalling molecules, ROS appear to also play a major role...
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Biochem Soc Trans (2014) 42 (3): 617–623.
Published: 22 May 2014
... be addressed (email enrique.amaya@manchester.ac.uk ). 14 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 metabolism reactive oxygen species tissue regeneration wound healing Xenopus Although mammals have relatively poor capacities to heal wounds...
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Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
...Ruben Quintana-Cabrera; Juan P. Bolaños Mitochondria are both the main producers and targets of ROS (reactive oxygen species). Among the battery of antioxidants that protect mitochondria from ROS, GSH is thought to be essential for the organelle antioxidant function. However, mitochondria cannot...
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Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
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Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., DNA damage and interference of reactive species with signal transduction pathways, which contribute significantly to β-cell dysfunction and death in Type 1 and Type 2 diabetes mellitus. Reactive oxygen species, superoxide radicals (O 2 •− ), hydrogen peroxide (H 2 O 2 ) and, in a final iron-catalysed...
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Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... Biochemical Society 2007 ATP ion channel NADPH oxidase P2X 7 phosphoinositide 3-kinase (PI3K) reactive nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic...
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Biochem Soc Trans (2007) 35 (5): 1119–1121.
Published: 25 October 2007
... email gcb@mole.bio.cam.ac.uk 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell death inflammation nitric oxide peroxynitrite reactive nitrogen species reactive oxygen species Inflammatory neurodegeneration is neurodegeneration caused...
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Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
... diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently activated after a single stimulus and maintain the elevated production of both cytokines...
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Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
...P. Behe; A.W. Segal The NADPH oxidase of ‘professional’ phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. It is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through...
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Biochem Soc Trans (2007) 35 (5): 1040–1042.
Published: 25 October 2007
...@stanford.edu ). 3 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis cardiac ischaemia/reperfusion injury ischaemic preconditioning proteasome protein kinase C (PKC) reactive oxygen species Cellular viability is determined by the balance of pro...
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Biochem Soc Trans (2007) 35 (5): 1156–1160.
Published: 25 October 2007
... implications. 1 To whom correspondence should be addressed (email calarcon@us.es ). 24 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant copper DNA damage pro-oxidant reactive oxygen species resveratrol Resveratrol (3,4′,5...
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Biochem Soc Trans (2007) 35 (3): 464–465.
Published: 22 May 2007
...-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte–CMR interactions may be important in early atherosclerosis when many activated monocytes are found...
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Biochem Soc Trans (2007) 35 (2): 188–192.
Published: 20 March 2007
... on chromosome 10 (PTEN) phosphatidylinositol trisphosphate metabolism phosphorylation reactive oxygen species Src homology 2-containing inositol phosphatase-2 (SHIP2) We have consistently observed in a range of cell types that basal levels of PtdIns(3,4) P 2 are extremely low and that the relative...
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Biochem Soc Trans (2007) 35 (2): 284–287.
Published: 20 March 2007
... nuclear factor κB ROS reactive oxygen species References 1 Seatta M. Turato G. Maestrelli P. Mapp C.E. Fabbri L.M. Am. J. Respir. Crit. Care Med. 2001 163 1304 1309 2 Higgins M. Ann. N.Y. Acad. Sci. 1991 624 7 17 3 MacNee W...
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Biochem Soc Trans (2006) 34 (5): 806–810.
Published: 25 October 2006
...H. Freeman; K. Shimomura; R.D. Cox; F.M. Ashcroft This paper reviews recent studies on the role of Nnt (nicotinamide nucleotide transhydrogenase) in insulin secretion and detoxification of ROS (reactive oxygen species). Glucose-stimulated insulin release from pancreatic β-cells is mediated...
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Biochem Soc Trans (2006) 34 (5): 919–921.
Published: 25 October 2006
... (Bristol, U.K.), C. Connolly (Dundee, U.K.), A. Dolphin (University College London, U.K.), J. Henley (Bristol, U.K.), A. Lai (Cardiff, U.K.) and C. Taylor (Cambridge, U.K.). DTT dithiothreitol ROS reactive oxygen species RyR ryanodine receptor SR sarcoplasmic reticulum...
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Biochem Soc Trans (2006) 34 (5): 802–805.
Published: 25 October 2006
.... These results support a role for UCP2 as a gene contributing to the pathogenesis of Type 2 diabetes. © 2006 The Biochemical Society 2006 fatty acid insulin secretion islet metabolism reactive oxygen species Type 2 diabetes uncoupling protein UCP2 (uncoupling protein-2) was identified...
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Biochem Soc Trans (2006) 34 (5): 965–970.
Published: 25 October 2006
...D. Salvemini; T.M. Doyle; S. Cuzzocrea A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use...
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Biochem Soc Trans (2005) 33 (6): 1390–1393.
Published: 26 October 2005
...@mrc-dunn.cam.ac.uk ). 24 6 2005 © 2005 The Biochemical Society 2005 disulphide glutathione mitochondrion oxidative stress protein thiol reactive oxygen species There are a variety of mitochondrial PrSHs (protein thiols), which can be divided into (i) essential thiols...
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Biochem Soc Trans (2005) 33 (1): 300–301.
Published: 01 February 2005
... apoptosis β cell glucose toxicity hyperglycaemia reactive oxygen species superoxide The ROS-suppressive effect of glucose in pancreatic β cells is at variance with the hypothesis that high rates of glucose catabolism unequivocally cause oxidative stress in all tissues [ 2 ]. It is however...
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Biochem Soc Trans (2004) 32 (6): 1011–1014.
Published: 26 October 2004
... have targeted antioxidants, spin traps, thiol reagents and DNA-alkylating compounds to mitochondria. The selective mitochondrial localization of these compounds enables us to investigate several aspects of the production of reactive oxygen species by mitochondria. 24 6 2004 © 2004...
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Biochem Soc Trans (2003) 31 (6): 1295–1299.
Published: 01 December 2003
...R.A.J. Smith; G.F. Kelso; F.H. Blaikie; C.M. Porteous; E.C. Ledgerwood; G. Hughes; A.M. James; M.F. Ross; J. Asin-Cayuela; H.M. Cochemé; A. Filipovska; M.P. Murphy The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain contributes to a range of pathologies, including...
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Biochem Soc Trans (2003) 31 (6): 1305–1307.
Published: 01 December 2003
... of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 9 June 2003 © 2003 Biochemical Society 2003 Age genes aging Caenorhabditis elegans lifespan oxidative stress reactive oxygen species Abbreviations used: IGF, insulin-like growth factor; ROS...
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Biochem Soc Trans (2003) 31 (5): 1059–1061.
Published: 01 October 2003
...J. Loscalzo ROS (reactive oxygen species) are normal products of oxidative cellular metabolism. These biochemically active free-radical derivatives of molecular oxygen serve as normal signalling molecules in the vasculature; however, an excess of vascular ROS flux occurs in the setting of risk...
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Biochem Soc Trans (2002) 30 (4): 762–766.
Published: 01 August 2002
... and interferonγ, and an enhanced activation of nuclear factor k B in the absence of tumour necrosis factor α stimulation, and enhanced production of reactive oxygen species after activation with activated zymosan and PMA. Such results may indicate an imbalance in the production of reactive oxygen and reactive...
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Biochem Soc Trans (2001) 29 (2): 337–340.
Published: 01 May 2001
... DNA oxidation 8-oxoguanine reactive oxygen species strand breaks Biochemical and Biomedical Aspects of Oxidative Mod if icat ion Irish Area Section Organized and Edited by R. J. H. Davies (School of Biology and Biochemistry, Medical Biology Centre, Queen's University, Belfast). Held at Queen's...
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Biochem Soc Trans (2001) 29 (2): 350–353.
Published: 01 May 2001
...F. M. Lyng; C. B. Seymour; C. Mothersill The ability of medium from γ-irradiated cells to induce early events in the apoptotic cascade, such as the mobilization of intracellular calcium, loss of mitochondrial membrane potential and increased levels of reactive oxygen species, in unirradiated cells...