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Keywords: reactive oxygen species
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Articles
Biochem Soc Trans (2022) 50 (5): 1377–1388.
Published: 06 September 2022
... restoration of blood flow is necessary to save brain tissue, it also causes reperfusion injury. Mitochondria play a crucial role in early ischemia-reperfusion injury due to the generation of reactive oxygen species (ROS). During ischemia, mitochondria sense energy depletion and futilely attempt to up-regulate...
Articles
Biochem Soc Trans (2021) 49 (6): 2929–2939.
Published: 09 December 2021
... that overcome these constraints and allow succinate oxidation to drive pmf too high can cause pathological generation of reactive oxygen species. We discuss the thermodynamic properties that allow succinate oxidation to drive pmf higher than NADH oxidation, and discuss the evidence for kinetic tuning of ATP...
Articles
Biochem Soc Trans (2022) 50 (1): 335–345.
Published: 11 January 2021
... and assesses newer approaches exploiting chemogenetic tools combined with genetically encoded biosensors. chemogenetics genetically encoded biosensors reactive nitrogen species reactive oxygen species signalling Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS) and a critical...
Articles
Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...
Articles
Biochem Soc Trans (2020) 48 (2): 719–731.
Published: 08 April 2020
.... It is proposed that PLA 2 and LAAO contribute to an elevated oxidative stress due to their catalytic actions, for instance, the ability of PLA 2 to produce reactive oxygen species during lipolysis and formation of H 2 O 2 from LAAO catalytic activity which consequently lead to cell death. Nonetheless, the cell...
Articles
Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
... 2019 8 11 2019 8 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bioenergetics calcium complex I mitochondria reactive oxygen species Introduction Mitochondria are distinguishable from the other numerous...
Articles
Biochem Soc Trans (2019) 47 (6): 1921–1930.
Published: 22 November 2019
...: the formation of neutrophil extracellular traps (NETs). Initially described as a highly organized and reactive oxygen species (ROS)-dependent function of neutrophils directed against bacteria [ 1 , 2 ], the last 15 years have seen numerous studies that identified a plethora of other NET triggers, elucidated...
Articles
Biochem Soc Trans (2019) 47 (5): 1461–1469.
Published: 10 September 2019
... mitochondria mitochondrial dysfunction reactive oxygen species superoxide There is a wealth of literature describing how mitochondrial superoxide and hydrogen peroxide act as messengers in redox signalling through different pathways. The ability of mitochondrial ROS to act as messengers...
Articles
Biochem Soc Trans (2019) 47 (1): 469–476.
Published: 19 February 2019
... of the Biochemical Society 2019 coenzyme A low-molecular-weight thiols post-translational modification protein CoAlation reactive oxygen species redox regulation in bacteria Bacteria are adapted to grow and survive in enormously diverse conditions under aerobic or anaerobic environments. Obligate...
Articles
Biochem Soc Trans (2015) 43 (3): 349–358.
Published: 01 June 2015
... to depend on its role as a guardian of phenotypic stability particularly with regard to the reactive oxygen species (ROS) and Ca 2+ signalling systems. Vitamin D maintains the expression of those signalling components responsible for stabilizing the low-resting state of these two signalling pathways...
Articles
Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... that repeated extreme exercise events could have deleterious effects on health, which might be brought about by the high levels of ROS (reactive oxygen species) produced during exercise. Studies that have examined biomarkers of oxidative damage following ultra-endurance exercise have found measurements...
Articles
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
...Anja Konzack; Thomas Kietzmann Superoxide and its derived ROS (reactive oxygen species) have been considered for a long time to be generated as toxic by-products of metabolic events. Although ROS generated in low amounts are able to act as signalling molecules, ROS appear to also play a major role...
Articles
Biochem Soc Trans (2014) 42 (3): 617–623.
Published: 22 May 2014
... be addressed (email enrique.amaya@manchester.ac.uk ). 14 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 metabolism reactive oxygen species tissue regeneration wound healing Xenopus The tadpole tail is a complex appendage, containing many axial tissues...
Articles
Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
...Ruben Quintana-Cabrera; Juan P. Bolaños Mitochondria are both the main producers and targets of ROS (reactive oxygen species). Among the battery of antioxidants that protect mitochondria from ROS, GSH is thought to be essential for the organelle antioxidant function. However, mitochondria cannot...
Articles
Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
Articles
Biochem Soc Trans (2011) 39 (5): 1376–1381.
Published: 21 September 2011
... of endothelial tip cells. By arginine depletion, ADI disturbs actin filament in endothelial tip cells, causing disordered migratory direction and decreased migration ability. Furthermore, ADI induces excessive synthesis of ROS (reactive oxygen species), and activates caspase 8-, but not caspase 9-, dependent...
Includes: Supplementary data
Articles
Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...
Articles
Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., DNA damage and interference of reactive species with signal transduction pathways, which contribute significantly to β-cell dysfunction and death in Type 1 and Type 2 diabetes mellitus. Reactive oxygen species, superoxide radicals (O 2 •− ), hydrogen peroxide (H 2 O 2 ) and, in a final iron-catalysed...
Articles
Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
... diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently activated after a single stimulus and maintain the elevated production of both cytokines...
Articles
Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
...P. Behe; A.W. Segal The NADPH oxidase of ‘professional’ phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. It is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through...
Articles
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... oxidase P2X 7 phosphoinositide 3-kinase (PI3K) reactive nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular...
Articles
Biochem Soc Trans (2007) 35 (5): 1119–1121.
Published: 25 October 2007
... circumstances are necessary for neuronal death and how to block it. 1 email gcb@mole.bio.cam.ac.uk 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell death inflammation nitric oxide peroxynitrite reactive nitrogen species reactive oxygen species...
Articles
Biochem Soc Trans (2007) 35 (5): 1040–1042.
Published: 25 October 2007
... function Reperfusion of ischaemic myocardium is associated with mitochondrial dysfunction resulting in generation of reactive oxygen species and diminished ATP production, both of which can lead to oxidative modification, dissociation and inhibition of the 26S proteasome. This would then decrease...
Articles
Biochem Soc Trans (2007) 35 (5): 1156–1160.
Published: 25 October 2007
... implications. 1 To whom correspondence should be addressed (email calarcon@us.es ). 24 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antioxidant copper DNA damage pro-oxidant reactive oxygen species resveratrol Resveratrol (3,4′,5...
Articles
Biochem Soc Trans (2007) 35 (3): 464–465.
Published: 22 May 2007
...-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte–CMR interactions may be important in early atherosclerosis when many activated monocytes are found...
Articles
Biochem Soc Trans (2007) 35 (2): 284–287.
Published: 20 March 2007
...@novartis.com 25 9 2006 © 2007 The Biochemical Society 2007 chronic obstructive pulmonary disease (COPD) histone deacetylase (HDAC) inflammatory response macrophage oxidative stress reactive oxygen species AP-1 activator protein 1 4-HNE 4-hydroxy-2-nonenal AGE...
Articles
Biochem Soc Trans (2007) 35 (2): 188–192.
Published: 20 March 2007
... 10 (PTEN) phosphatidylinositol trisphosphate metabolism phosphorylation reactive oxygen species Src homology 2-containing inositol phosphatase-2 (SHIP2) PtdIns(3,4,5) P 3 and PtdIns(3,4) P 2 are two important lipid signals that have overlapping, but distinctive roles. Independent...
Articles
Biochem Soc Trans (2006) 34 (5): 802–805.
Published: 25 October 2006
.... These results support a role for UCP2 as a gene contributing to the pathogenesis of Type 2 diabetes. 15 6 2006 © 2006 The Biochemical Society 2006 fatty acid insulin secretion islet metabolism reactive oxygen species Type 2 diabetes uncoupling protein UCP2 (uncoupling protein-2...
Articles
Biochem Soc Trans (2006) 34 (5): 806–810.
Published: 25 October 2006
...H. Freeman; K. Shimomura; R.D. Cox; F.M. Ashcroft This paper reviews recent studies on the role of Nnt (nicotinamide nucleotide transhydrogenase) in insulin secretion and detoxification of ROS (reactive oxygen species). Glucose-stimulated insulin release from pancreatic β-cells is mediated...
Articles
Biochem Soc Trans (2006) 34 (5): 960–964.
Published: 25 October 2006
..., ROS (reactive oxygen species) also have signalling roles, acting as second messengers that modulate the activity of diverse intracellular signalling pathways and transcription factors, thereby inducing changes in cell phenotype. NADPH oxidases appear to be especially important sources of ROS involved...
Articles
Biochem Soc Trans (2006) 34 (5): 965–970.
Published: 25 October 2006
...D. Salvemini; T.M. Doyle; S. Cuzzocrea A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use...
Articles
Biochem Soc Trans (2006) 34 (5): 953–956.
Published: 25 October 2006
...G.C. Brown; V. Borutaite ROS (reactive oxygen species) and RNS (reactive nitrogen species) are central to the innate immunity that protects us from infection, but also contribute to degenerative diseases and possibly aging. However, ROS and RNS are increasingly recognized to contribute...
Articles
Biochem Soc Trans (2006) 34 (5): 919–921.
Published: 25 October 2006
... at SECC Glasgow, U.K., 23–27 July 2006. Edited by G. Banting (Bristol, U.K.), C. Connolly (Dundee, U.K.), A. Dolphin (University College London, U.K.), J. Henley (Bristol, U.K.), A. Lai (Cardiff, U.K.) and C. Taylor (Cambridge, U.K.). calcium signalling reactive oxygen species redox regulation...
Articles
Biochem Soc Trans (2005) 33 (6): 1390–1393.
Published: 26 October 2005
... by direct reaction with ROS (reactive oxygen species) or reactive nitrogen species and as an electron donor for peroxidases [ 3 , 5 ]. GSH is oxidized to GSSG by ROS and by GPXs (glutathione peroxidases) [ 9 – 11 ]. GR (glutathione reductase) continually recycles GSSG back to GSH [ 3 , 7 , 12 ] keeping...
Articles
Biochem Soc Trans (2005) 33 (1): 300–301.
Published: 01 February 2005
... apoptosis β cell glucose toxicity hyperglycaemia reactive oxygen species superoxide Chronic hyperglycaemia has been shown to cause diabetic lesions in retina, nerves, kidney and vascular endothelial cells and is also suspected of negatively affecting the function of insulin-producing β cells...
Articles
Biochem Soc Trans (2004) 32 (6): 1011–1014.
Published: 26 October 2004
... have targeted antioxidants, spin traps, thiol reagents and DNA-alkylating compounds to mitochondria. The selective mitochondrial localization of these compounds enables us to investigate several aspects of the production of reactive oxygen species by mitochondria. 1 Correspondence address...
Articles
Biochem Soc Trans (2004) 32 (2): 338–342.
Published: 01 April 2004
... and by endogenously produced reactive oxygen species. This mechanism provides a novel means to stimulate phosphoinositide 3-kinase-dependent signalling pathways, which may be important in circumstances where PtdIns(3,4,5) P 3 and oxidants are produced concurrently. 1 To whom correspondence should be addressed (e...
Articles
Biochem Soc Trans (2003) 31 (6): 1295–1299.
Published: 01 December 2003
...R.A.J. Smith; G.F. Kelso; F.H. Blaikie; C.M. Porteous; E.C. Ledgerwood; G. Hughes; A.M. James; M.F. Ross; J. Asin-Cayuela; H.M. Cochemé; A. Filipovska; M.P. Murphy The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain contributes to a range of pathologies, including...
Articles
Biochem Soc Trans (2003) 31 (6): 1300–1301.
Published: 01 December 2003
...S. Miwa; M.D. Brand Mitochondria produce ROS (reactive oxygen species) as a by-product of aerobic respiration. Several studies in mammals and birds suggest that the most physiologically relevant ROS production is from complex I following reverse electron flow, and is highly sensitive to membrane...
Articles
Biochem Soc Trans (2003) 31 (6): 1305–1307.
Published: 01 December 2003
...-throughput screens for compounds that affect nematode survival in the face of acute oxidative stress and will facilitate the identification of novel drugs that extend nematode lifespan. Age genes aging Caenorhabditis elegans lifespan oxidative stress reactive oxygen species Abbreviations...
Articles
Biochem Soc Trans (2003) 31 (6): 1316–1317.
Published: 01 December 2003
... of reactive oxygen species. 1 e-mail pvn@main.vsu.ru 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 24 June 2003 © 2003 Biochemical Society 2003 alternative oxidase non-coupled respiration reactive oxygen species uncoupled...
Articles
Biochem Soc Trans (2003) 31 (5): 1059–1061.
Published: 01 October 2003
...J. Loscalzo ROS (reactive oxygen species) are normal products of oxidative cellular metabolism. These biochemically active free-radical derivatives of molecular oxygen serve as normal signalling molecules in the vasculature; however, an excess of vascular ROS flux occurs in the setting of risk...
Articles
Biochem Soc Trans (2002) 30 (4): 762–766.
Published: 01 August 2002
... and interferonγ, and an enhanced activation of nuclear factor k B in the absence of tumour necrosis factor α stimulation, and enhanced production of reactive oxygen species after activation with activated zymosan and PMA. Such results may indicate an imbalance in the production of reactive oxygen and reactive...
Articles
Biochem Soc Trans (2001) 29 (2): 337–340.
Published: 01 May 2001
... DNA oxidation 8-oxoguanine reactive oxygen species strand breaks CHO, Chinese hamster ovary FPG, form midopyrimidine glycosylase Biochemical and Biomedical Aspects of Oxidative Mod if icat ion Irish Area Section Organized and Edited by R. J. H. Davies (School of Biology and Biochemistry...
Articles
Biochem Soc Trans (2001) 29 (2): 350–353.
Published: 01 May 2001
...F. M. Lyng; C. B. Seymour; C. Mothersill The ability of medium from γ-irradiated cells to induce early events in the apoptotic cascade, such as the mobilization of intracellular calcium, loss of mitochondrial membrane potential and increased levels of reactive oxygen species, in unirradiated cells...