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Biochem Soc Trans (2016) 44 (4): 987–993.
Published: 15 August 2016
.... Aminoglycosides target ribosomes. We describe the interactions of aminoglycoside antibiotics containing a 2-deoxystreptamine (2-DOS) ring with 16S rRNA. We review the computational studies, with a focus on molecular dynamics (MD) simulations performed on RNA models mimicking the 2-DOS aminoglycoside binding site...
Biochem Soc Trans (2013) 41 (4): 923–926.
Published: 18 July 2013
..., and the production of new ribosomes, in the longer term. mTORC1 signalling stimulates the translation of the mRNAs encoding the ribosomal proteins, activates RNA polymerases I and III, which make the rRNAs, and promotes the processing of the precursor for the main rRNAs. Taken together, these effects allow mTORC1...
Biochem Soc Trans (2006) 34 (6): 1079–1081.
Published: 25 October 2006
...T. Moss; V. Stefanovsky; F. Langlois; T. Gagnon-Kugler Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA...
Biochem Soc Trans (2004) 32 (2): 218–221.
Published: 01 April 2004
...G.C. Baker; D.A. Cowan Our understanding of thermophile diversity is based predominantly on PCR studies of community DNA. ‘Universal’ and domain-specific rRNA gene PCR primers have historically been used for the assessment of microbial diversity without adequate regard to the degree of specificity...