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Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1220–1224.
Published: 24 September 2010
... in the magnetic resonance experiment >10000 times, allowing us to image labelled cell substrates in vivo and their subsequent metabolism. We showed that exchange of hyperpolarized 13 C label between lactate and pyruvate, catalysed by lactate dehydrogenase, was decreased in treated tumours undergoing drug...