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Keywords: pteridine reductase
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Biochem Soc Trans (2007) 35 (5): 980–984.
Published: 25 October 2007
... acid and amino acid biosyntheses. These parasites rely on a bifunctional DHFR (dihydrofolate reductase)–TS (thymidylate synthase) and PTR1 (pteridine reductase 1) to carry out reductions of acquired pterins [ 18 ]. Enzymes of folate metabolism are proven targets for the treatment of bacterial and some...
Biochem Soc Trans (2003) 31 (3): 607–610.
Published: 01 June 2003
... components, and are now studying enzyme–ligand complexes of the first enzyme, trypanothione reductase. Also with regard to trypanosomatids, a question that arose was: why do anti-folates not provide useful therapies? The enzyme pteridine reductase has been shown to contribute to anti-folate drug resistance...