... acid and amino acid biosyntheses. These parasites rely on a bifunctional DHFR (dihydrofolate reductase)–TS (thymidylate synthase) and PTR1 (pteridine reductase 1) to carry out reductions of acquired pterins [ 18 ]. Enzymes of folate metabolism are proven targets for the treatment of bacterial and some...

... components, and are now studying enzyme–ligand complexes of the first enzyme, trypanothione reductase. Also with regard to trypanosomatids, a question that arose was: why do anti-folates not provide useful therapies? The enzyme pteridine reductase has been shown to contribute to anti-folate drug resistance...