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Keywords: pseudokinases
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Biochem Soc Trans (2019) 47 (6): 1597–1608.
Published: 26 November 2019
... combining structural, biochemical, and functional approaches revealed that these pseudokinases have crucial roles in vivo and may even represent attractive targets for pharmacological intervention. Pseudokinases mediate signal transduction by a diversity of mechanisms, including allosteric regulation...
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
...Annette V. Jacobsen; James M. Murphy Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ∼10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies...
Biochem Soc Trans (2017) 45 (3): 653–663.
Published: 15 June 2017
... protein kinases are, however, thought to be catalytically inactive. These kinases lack conserved residues of the kinase core and are classified as pseudokinases. Yet, it has been demonstrated that pseudokinases are critically involved in biological functions. Here, we show how pseudokinases have developed...