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Keywords: pseudoenzyme
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Articles
Biochem Soc Trans (2018) 46 (6): 1713–1720.
Published: 04 December 2018
...Amy L. Stiegler; Titus J. Boggon Pseudoenzymes generally lack detectable catalytic activity despite adopting the overall protein fold of their catalytically competent counterparts, indeed ‘pseudo’ family members seem to be incorporated in all enzyme classes. The small GTPase enzymes are important...
Articles
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
... protein–protein interactions pseudoenzyme pseudokinases signalling Counterparts of active enzymes that lack key catalytic residues and are therefore predicted to possess defective catalytic activities, termed pseudoenzymes, are thought to comprise ∼10% of proteomes throughout the kingdoms...
Articles
Biochem Soc Trans (2017) 45 (2): 537–544.
Published: 13 April 2017
...James M. Murphy; Hesso Farhan; Patrick A. Eyers Pseudoenzymes are catalytically dead counterparts of enzymes. Despite their first description some 50 years ago, the importance and functional diversity of these ‘fit-for-purpose’ polypeptides is only now being appreciated. Pseudoenzymes have been...
Articles
Biochem Soc Trans (2017) 45 (2): 449–456.
Published: 13 April 2017
...Veronika Reiterer; Krzysztof Pawłowski; Hesso Farhan The pseudophosphatase STYX (serine/threonine/tyrosine interacting protein) is a catalytically inactive member of the protein tyrosine phosphatase family. We perform a phylogenetic analysis of STYX and ask how far does the pseudoenzyme status...
Articles
Biochem Soc Trans (2013) 41 (4): 969–974.
Published: 18 July 2013
... 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 kinome protein scaffold pseudoenzyme pseudokinase thermal shift assay Although the catalytic activity of conventional protein kinases can usually be readily established by measuring ATP hydrolysis...