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Keywords: proteomics
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Articles
Biochem Soc Trans (2022) 50 (1): 13–20.
Published: 15 February 2022
... efforts have been invested in unravelling and manipulating signalling mechanisms regulating these two different types of cell death. Here I discuss how modern proteomic approaches like phosphoproteomics and secretomics provide a novel perspective on this central cytokine and its effect on inflammation...
Articles
Biochem Soc Trans (2021) 49 (5): 1905–1926.
Published: 10 August 2021
... understanding these organisms, and a substantial proportion of genes remain functionally unknown. Methodological advances, principally mass spectrometry (MS), are paving the way for parallel analysis of the proteome, metabolome and lipidome. Each provides a global, complementary assay, in addition to genomics...
Articles
Biochem Soc Trans (2021) 49 (4): 1643–1662.
Published: 20 July 2021
... Press and the Biochemical Society under a transformative agreement with CAUL. glycobiology glycomics glycoproteomics mass spectrometry multi-omics proteomics Protein post-translational modifications (PTMs) enable the cell to produce profound structural and functional diversity from...
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Biochem Soc Trans (2020) 48 (5): 1953–1966.
Published: 20 October 2020
... proteomics. Although once limited in throughput and sensitivity, proteomic studies have quickly grown in scope and scale over the last decade due to significant advances in instrumentation, computational approaches, and bio-sample preparation. Here, we review these latest developments in MS and highlight how...
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Biochem Soc Trans (2020) 48 (3): 1153–1165.
Published: 15 June 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 bioconjugation peptide ligase protease protein engineering protein termini proteomics The ability to site-specifically modify proteins with chemical probes and payloads that cannot be genetically...
Articles
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
... approaches, where MS is used alongside other techniques such as ion-mobility spectrometry. We also review how the emergence of a native top-down approach, which combines native MS with top-down proteomics into a single experiment, is the pièce de résistance of structural mass spectrometry's coming of age...
Articles
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
... of the Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate...
Articles
Biochem Soc Trans (2016) 44 (4): 994–1004.
Published: 15 August 2016
... 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cell biology protein–protein interactions proteomics signalling pathways Signalling proteins are essential cellular molecules with responsibility for almost every aspect...
Articles
Biochem Soc Trans (2014) 42 (6): 1698–1703.
Published: 17 November 2014
...Robert J. Beynon; Dean Hammond; Victoria Harman; Yvonne Woolerton The increasing acceptance that proteins may exert multiple functions in the cell brings with it new analytical challenges that will have an impact on the field of proteomics. Many proteomics workflows begin by destroying information...
Articles
Biochem Soc Trans (2013) 41 (4): 1089–1095.
Published: 18 July 2013
... biochemical and proteomic analyses. Higher eukaryotes are known to contain kinases and phosphatases that control the reversible phosphorylation of histidine residues, yet primary sequence analysis indicates that these organisms do not possess homologues of the ‘two-component’ systems described above [ 8...
Articles
Biochem Soc Trans (2013) 41 (1): 43–49.
Published: 29 January 2013
...Brent R. Martin Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory...
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Articles
Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
...Xuan Liu; De-An Guo Systems biology is considered to be the possible technology that could bring breakthroughs in the study of TCM (traditional Chinese medicine). Proteomics, as one of the major components of systems biology, has been used in the mechanistic study of TCM, providing some interesting...
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Articles
Biochem Soc Trans (2009) 37 (4): 868–872.
Published: 22 July 2009
... the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics. 1 To whom correspondence should be addressed (email bln1@soton.ac.uk ). 4 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Contaminants apart...
Articles
Biochem Soc Trans (2009) 37 (1): 1–6.
Published: 20 January 2009
.... Quantitative proteomics of the archaeon Methanococcus maripaludis validated by microarray analysis and real time PCR Mol. Cell. Proteomics 2006 5 868 881 M. maripaludis is a mesophilic methanogen, first isolated from salt marshes in North Carolina in the 1980s [ 36 ]. M. maripaludis...
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Biochem Soc Trans (2008) 36 (5): 802–806.
Published: 19 September 2008
... targets for the pathway. Until recently, the cullin family of proteins was characterized as the only substrates for NEDDylation. However, through either direct biological approaches or the use of proteomics, it is now evident that the NEDD8 proteome is more diverse than thought previously. The present...
Articles
Biochem Soc Trans (2008) 36 (5): 823–827.
Published: 19 September 2008
... © The Authors Journal compilation © 2008 Biochemical Society 2008 histidine tag proteomics purification ubiquitin-associated domain (UBA domain) ubiquitination ubiquitin-interacting motif (UIM) The modification of a substrate with ubiquitin may be in the form of mono...
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Biochem Soc Trans (2007) 35 (3): 588–593.
Published: 22 May 2007
... proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. However, gel-based proteomics is methodologically restricted from the low mass region, which includes important endogenous peptides. The study of endogenous peptides, peptidomics, is complicated...
Articles
Biochem Soc Trans (2006) 34 (6): 1246–1251.
Published: 25 October 2006
... and quantification of CYP enzymes, and in the present paper we will review the current state of the technology for such an analysis. © 2006 The Biochemical Society 2006 cytochrome P450 liquid chromatography–MS one-dimensional gel electrophoresis proteomics quantification tandem MS At present...
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Biochem Soc Trans (2005) 33 (3): 503–506.
Published: 01 June 2005
... J.M. Petty J. Riba-Garcia I. Robertson D.H.L. Gaskell S.J. Oliver S.G. Beynon R.J. Mol. Cell. Proteomics 2002 1 579 591 8 Minton A.P. J. Biol. Chem. 2001 276 10577 10580 9 Srere P.A. Annu. Rev. Biochem. 1987 56 89 124 10...
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Biochem Soc Trans (2005) 33 (3): 530–534.
Published: 01 June 2005
... that enables the proteomics community to build a reliable scaffold of the interactome in a fraction of the time compared with uncoordinated efforts. 1 To whom correspondence should be addressed (email liisa.holm@helsinki.fi ). 19 1 2005 © 2005 The Biochemical Society 2005 This work...
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Biochem Soc Trans (2005) 33 (2): 409–412.
Published: 01 April 2005
...P.B. Maguire; M. Foy; D.J. Fitzgerald Proteomics has provided powerful new insights into the complex events of the anucleate platelet and has revealed many potential protein targets in the search for suitable agents for thrombotic disease. In the present study, we summarize recent proteomic...
Articles
Biochem Soc Trans (2004) 32 (5): 851–855.
Published: 26 October 2004
...-protein-coupled receptors) are part of multiprotein networks organized around scaffolding proteins. These GIPs (GPCR-interacting proteins) are either transmembrane or cytosolic proteins. Proteomic approaches can be used to get global pictures of these ‘receptosomes’. This approach allowed us to identify...
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Biochem Soc Trans (2004) 32 (4): 601–605.
Published: 01 August 2004
.... Biochemical analysis has identified both general and specific mRNA-binding proteins as components of the regulation of chloroplast translation, and has revealed that chloroplast translation is related to bacterial translation but is more complex. Utilizing proteomic and bioinformatic analyses, we have...
Articles
Biochem Soc Trans (2003) 31 (6): 1488–1490.
Published: 01 December 2003
... of cancer using tyrosine kinase inhibitors and the use of proteomic analysis to identify possible markers of activity of these new drugs. 1 To whom correspondence should be addressed (e-mail cmm10@kent.ac.uk ). Unravelling Nature's Networks a Biochemical Society Focused Meeting held at University...
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Biochem Soc Trans (2003) 31 (6): 1457–1461.
Published: 01 December 2003
... Networks a Biochemical Society Focused Meeting held at University of Sheffield, 21 July 2003 genomics mathematical modelling microarray modularity networks proteomics U nravelling N ature s N etw orks Biochem icalSociety Focused M eeting Unravelling Nature s Networks: From Microarray...
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Biochem Soc Trans (2002) 30 (4): 802–806.
Published: 01 August 2002
...-mail jmcooper@elec.gla.ac.uk 9 4 2002 © 2002 Biochemical Society 2002 cell screen high throughput proteomics Bio-MEMS, biological micro-electromechanical machines MST, microsystems technology LOAC, Lab-on-a-Chip APL, Adaptive Profiling Biochemical Society Transactions (2002...
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