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Keywords: proteomics
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Biochem Soc Trans (2022) 50 (1): 13–20.
Published: 15 February 2022
... efforts have been invested in unravelling and manipulating signalling mechanisms regulating these two different types of cell death. Here I discuss how modern proteomic approaches like phosphoproteomics and secretomics provide a novel perspective on this central cytokine and its effect on inflammation...
Biochem Soc Trans (2021) 49 (5): 1905–1926.
Published: 10 August 2021
... understanding these organisms, and a substantial proportion of genes remain functionally unknown. Methodological advances, principally mass spectrometry (MS), are paving the way for parallel analysis of the proteome, metabolome and lipidome. Each provides a global, complementary assay, in addition to genomics...
Biochem Soc Trans (2021) 49 (4): 1643–1662.
Published: 20 July 2021
..., transcriptomics or metabolomic analyses can be retrieved before the separation of lipids and glycolipids from glycoproteins for example by chloroform:methanol:water extraction. Stage II : Glycoproteins are digested using proteases, and can be either directly analysed (label-free proteomics) or subjected...
Biochem Soc Trans (2020) 48 (5): 1953–1966.
Published: 20 October 2020
... proteomics. Although once limited in throughput and sensitivity, proteomic studies have quickly grown in scope and scale over the last decade due to significant advances in instrumentation, computational approaches, and bio-sample preparation. Here, we review these latest developments in MS and highlight how...
Biochem Soc Trans (2020) 48 (3): 1153–1165.
Published: 15 June 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 bioconjugation peptide ligase protease protein engineering protein termini proteomics The ability to site-specifically modify proteins with chemical probes and payloads that cannot be genetically...
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
... approaches, where MS is used alongside other techniques such as ion-mobility spectrometry. We also review how the emergence of a native top-down approach, which combines native MS with top-down proteomics into a single experiment, is the pièce de résistance of structural mass spectrometry's coming of age...
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
... of the Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate...
Biochem Soc Trans (2016) 44 (4): 994–1004.
Published: 15 August 2016
... 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cell biology protein–protein interactions proteomics signalling pathways Signalling proteins are essential cellular molecules with responsibility for almost every aspect...
Biochem Soc Trans (2014) 42 (6): 1698–1703.
Published: 17 November 2014
...Robert J. Beynon; Dean Hammond; Victoria Harman; Yvonne Woolerton The increasing acceptance that proteins may exert multiple functions in the cell brings with it new analytical challenges that will have an impact on the field of proteomics. Many proteomics workflows begin by destroying information...
Biochem Soc Trans (2013) 41 (4): 1089–1095.
Published: 18 July 2013
... Society 2013 histidine mass spectrometry phosphate transfer phosphohistidine phosphorylation proteomics In prokaryotes, fungi and plants, histidine kinase function is well documented. Targeted analyses in these organisms have demonstrated that autophosphorylation of transmembrane...
Biochem Soc Trans (2013) 41 (1): 43–49.
Published: 29 January 2013
...Brent R. Martin Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory...
Biochem Soc Trans (2012) 40 (6): 1204–1210.
Published: 21 November 2012
... is available. To investigate and compare c -type cytochrome expression in S. oneidensis strain MR-1 and Anaeromyxobacter dehalogenans strain 2CP-C more comprehensively, proteomic measurements were used to characterize lysates of cells grown with soluble Fe(III) (as ferric citrate) and insoluble Mn(IV) (as MnO...
Includes: Supplementary data
Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
...Xuan Liu; De-An Guo Systems biology is considered to be the possible technology that could bring breakthroughs in the study of TCM (traditional Chinese medicine). Proteomics, as one of the major components of systems biology, has been used in the mechanistic study of TCM, providing some interesting...
Biochem Soc Trans (2010) 38 (1): 87–91.
Published: 19 January 2010
..., the proteomic methods currently used to identify new ubiquitinated proteins in response to DNA damage, including the advantages of using the UBD (ubiquitin-binding domain) beads to purify the ubiquitinated proteins, are considered. 1 To whom correspondence should be addressed (email amoumen@sgul.ac.uk...
Biochem Soc Trans (2009) 37 (4): 868–872.
Published: 22 July 2009
... the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics. 1 To whom correspondence should be addressed (email bln1@soton.ac.uk ). 4 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 biomarker chronic lung...
Biochem Soc Trans (2009) 37 (1): 1–6.
Published: 20 January 2009
... Methanococcus maripaludis minichromosome maintenance (MCM) proteomics The initiation of DNA replication from specific sites (origins of replication) must be carefully controlled in order to ensure that DNA is replicated only once during each cell cycle [ 1 ]. In eukaryotes, a large number of proteins...
Biochem Soc Trans (2008) 36 (5): 802–806.
Published: 19 September 2008
... targets for the pathway. Until recently, the cullin family of proteins was characterized as the only substrates for NEDDylation. However, through either direct biological approaches or the use of proteomics, it is now evident that the NEDD8 proteome is more diverse than thought previously. The present...
Biochem Soc Trans (2008) 36 (5): 823–827.
Published: 19 September 2008
... © The Authors Journal compilation © 2008 Biochemical Society 2008 histidine tag proteomics purification ubiquitin-associated domain (UBA domain) ubiquitination ubiquitin-interacting motif (UIM) In order to detect, purify and characterize ubiquitinated proteins, preservation...
Biochem Soc Trans (2007) 35 (3): 588–593.
Published: 22 May 2007
... proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. However, gel-based proteomics is methodologically restricted from the low mass region, which includes important endogenous peptides. The study of endogenous peptides, peptidomics, is complicated...
Biochem Soc Trans (2006) 34 (6): 1246–1251.
Published: 25 October 2006
... chromatography–MS one-dimensional gel electrophoresis proteomics quantification tandem MS At present, there are more than 270 different CYP (cytochrome P450) gene families, with 18 recorded in mammals ( http://drnelson.utmem.edu/CytochromeP450.html ). In human, there are 57 CYP genes arranged...
Biochem Soc Trans (2005) 33 (3): 503–506.
Published: 01 June 2005
...) or by degradation [ 7 ]. 1 email m.williamson@sheffield.ac.uk 10 1 2005 © 2005 The Biochemical Society 2005 interdisciplinary research modelling proteomics systems biology There are many different definitions of systems biology, which is in danger of becoming something...
Biochem Soc Trans (2005) 33 (3): 530–534.
Published: 01 June 2005
... that enables the proteomics community to build a reliable scaffold of the interactome in a fraction of the time compared with uncoordinated efforts. Figure 1 Generating interaction networks Proteins are represented by circles (nodes) and interactions by lines (edges). The raw data gives binary...
Biochem Soc Trans (2005) 33 (2): 409–412.
Published: 01 April 2005
...P.B. Maguire; M. Foy; D.J. Fitzgerald Proteomics has provided powerful new insights into the complex events of the anucleate platelet and has revealed many potential protein targets in the search for suitable agents for thrombotic disease. In the present study, we summarize recent proteomic...
Biochem Soc Trans (2004) 32 (5): 851–855.
Published: 26 October 2004
...-protein-coupled receptors) are part of multiprotein networks organized around scaffolding proteins. These GIPs (GPCR-interacting proteins) are either transmembrane or cytosolic proteins. Proteomic approaches can be used to get global pictures of these ‘receptosomes’. This approach allowed us to identify...
Biochem Soc Trans (2004) 32 (4): 601–605.
Published: 01 August 2004
.... Biochemical analysis has identified both general and specific mRNA-binding proteins as components of the regulation of chloroplast translation, and has revealed that chloroplast translation is related to bacterial translation but is more complex. Utilizing proteomic and bioinformatic analyses, we have...
Biochem Soc Trans (2003) 31 (6): 1488–1490.
Published: 01 December 2003
... of cancer using tyrosine kinase inhibitors and the use of proteomic analysis to identify possible markers of activity of these new drugs. 1 To whom correspondence should be addressed (e-mail cmm10@kent.ac.uk ). Unravelling Nature's Networks a Biochemical Society Focused Meeting held at University...
Biochem Soc Trans (2003) 31 (6): 1457–1461.
Published: 01 December 2003
... at University of Sheffield, 21 July 2003 19 September 2003 © 2003 Biochemical Society 2003 genomics mathematical modelling microarray modularity networks proteomics U nravelling N ature s N etw orks Biochem icalSociety Focused M eeting Unravelling Nature s Networks: From Microarray...
Biochem Soc Trans (2002) 30 (4): 802–806.
Published: 01 August 2002
...-mail jmcooper@elec.gla.ac.uk 9 4 2002 © 2002 Biochemical Society 2002 cell screen high throughput proteomics Bio-MEMS, biological micro-electromechanical machines MST, microsystems technology LOAC, Lab-on-a-Chip APL, Adaptive Profiling Biochemical Society Transactions (2002...
Biochem Soc Trans (2002) 30 (2): 82–87.
Published: 01 April 2002
... biochip proteomics SELDI Biochemical Society Transactions (2002) Volume 30, part 2 general basis. In our opinion, the variety of genomic questions has to be matched by the flexi- bility of the technology. Especially in the micro- array field, flexibility and accessibility will be the key...