... via intra-mitochondrial proteolysis involving multiple AAA+ proteases. Together, these proteolytic pathways maintain the activity and homeostasis of OXPHOS components. degradation mitochondria oxidative phosphorylation protease proteolysis respiratory system Correspondence: Monika W...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 extracellular matrix fibrosis heat shock proteins molecular chaperones proteolysis The extracellular matrix (ECM) is a three-dimensional network of carbohydrates and proteins exported from the cell...

... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...

... cleavage site, as is evident from mutagenesis [ 5 , 26 ]. The consensus sequence at Asp 421 is recognized by caspase 3 and caspase 7 and mutation of this residue to glutamate inhibits caspase-mediated tau proteolysis [ 27 ]. Transfection of cells with the fragment of tau corresponding to residues 1–421...

...Yipeng Wang; Sarika Garg; Eva-Maria Mandelkow; Eckhard Mandelkow Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays...

... stimulates a programme of tyrosine phosphorylation, ubiquitination and proteolysis. This is linked to ESCRT (endosomal sorting complex required for transport)-mediated recognition of activated VEGFR2 and sorting in endosomes before arrival in lysosomes for terminal degradation. In addition, Rab GTPases...

...Gemma Marfany; Rosa Farràs; Eduardo Salido; Dimitris P. Xirodimas; Manuel S. Rodríguez Proteolysis has traditionally been considered as a radical way to terminate the function of a protein. However, protein destruction also is the starting point for many processes as they can only occur when...

... results in a latent 20S core particle that can serve further as a platform for 19S regulatory particle attachment and formation of the biologically active 26S proteasome for ubiquitin-dependent proteolysis. Both general and dedicated proteasome assembly chaperones regulate the efficiency and outcome...

...Catherine Lindon Inactivation of key substrates by ubiquitin-mediated proteolysis controls the passage of cells through mitosis. The APC/C (anaphase-promoting complex/cyclosome) targets a large number of substrates for proteolysis during the final steps of mitosis and cytokinesis...

... and composition in more subtle ways. For instance, proteolysis of tenascin-C releases fragments that inhibit fibroblast migration from this molecule which, when intact, stimulates migration. In this way, proteolysis may limit fibroblast infiltration into a wound bed. Conversely, lack of proteolytic activity...

... 801 The Arabidopsis genome also contains predicted components of the aspartate protease containing γ secretase complex [ 41 , 46 ] and seven Rhomboid class serine proteases [ 47 ], both of which have been implicated in the intramembrane proteolysis of both membrane-located ligand precursors...

... a prerequisite for the octarepeat region in the N-terminus of the protein. Significantly, two disease-associated mutants of PrP, namely PG14 and A116V (Ala 116 →Val), were unable to undergo β-cleavage and this lack of proteolysis was accompanied by functional consequences in cells expressing these mutant...

... © 2004 The Biochemical Society 2004 apoptosis eukaryotic initiation factor (eIF) mRNA protein synthesis proteolysis translation inhibition Protein synthesis can be conveniently subdivided into three phases: initiation, elongation and termination. It is now clear...

... 2004 Alzheimer's disease amyloidogenesis cholesterol glycosylation lovastatin proteolysis β-secretase Abbreviations used: Aβ, β-amyloid; APP, Alzheimer's amyloid precursor protein; APPswe, Swedish mutant of APP; ASP-2, aspartic protease 2; FCS, fetal calf serum; Endo H...

... and possible exploitation as therapeutic targets. The Behaviour of Enzymes in Cells 723 Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries A.J. Turner1 Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K...

..., protein degradation serves as an important mechanism for acclimation of the Key words: chloroplast, DegP, RsH, proteolysis. Abbreviations used: PS II, photosystem II; RISP, Rieske Fe-S protein. 'To whom correspondence should be addressed (e-mail zach@agri.huji.ac.il). photosynthetic machinery to changes...

... functions during the biogenesis of mitochondria. Their activity is modulated by another membrane-protein complex that is composed of prohibitins. Peptides generated upon proteolysis in the matrix space are transported across the inner membrane by an ATP-binding cassette transporter. The function...