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Keywords: proteolysis
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Articles
Biochem Soc Trans (2024) BST20230918.
Published: 08 February 2024
.... The activity of the LDLR is also regulated by proteolysis. Proteolytic cleavage of the transmembrane region of the LDLR by γ-secretase destabilises the receptor, directing it to the lysosome for degradation. Shedding of the extracellular domain of the receptor by membrane-type 1 matrix metalloprotease...
Articles
Biochem Soc Trans (2022) 50 (3): 1119–1132.
Published: 19 May 2022
... via intra-mitochondrial proteolysis involving multiple AAA+ proteases. Together, these proteolytic pathways maintain the activity and homeostasis of OXPHOS components. Correspondence: Monika W. Murcha ( monika.murcha@uwa.edu.au ) 9 2 2022 7 4 2022 3 5 2022 Regulation...
Articles
Biochem Soc Trans (2021) 49 (6): 2611–2625.
Published: 16 December 2021
... extracellular matrix fibrosis heat shock proteins molecular chaperones proteolysis The extracellular matrix (ECM) is a three-dimensional network of carbohydrates and proteins exported from the cell into the extracellular space to act as a scaffold for biological processes like tissue organisation...
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Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...
Articles
Biochem Soc Trans (2010) 38 (4): 1016–1020.
Published: 26 July 2010
... cleavage site, as is evident from mutagenesis [ 5 , 26 ]. The consensus sequence at Asp 421 is recognized by caspase 3 and caspase 7 and mutation of this residue to glutamate inhibits caspase-mediated tau proteolysis [ 27 ]. Transfection of cells with the fragment of tau corresponding to residues 1–421...
Articles
Biochem Soc Trans (2010) 38 (4): 955–961.
Published: 26 July 2010
...Yipeng Wang; Sarika Garg; Eva-Maria Mandelkow; Eckhard Mandelkow Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays...
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Biochem Soc Trans (2008) 36 (5): 807–812.
Published: 19 September 2008
... results in a latent 20S core particle that can serve further as a platform for 19S regulatory particle attachment and formation of the biologically active 26S proteasome for ubiquitin-dependent proteolysis. Both general and dedicated proteasome assembly chaperones regulate the efficiency and outcome...
Articles
Biochem Soc Trans (2008) 36 (3): 405–410.
Published: 21 May 2008
...Catherine Lindon Inactivation of key substrates by ubiquitin-mediated proteolysis controls the passage of cells through mitosis. The APC/C (anaphase-promoting complex/cyclosome) targets a large number of substrates for proteolysis during the final steps of mitosis and cytokinesis...
Articles
Biochem Soc Trans (2007) 35 (4): 643–646.
Published: 20 July 2007
... and composition in more subtle ways. For instance, proteolysis of tenascin-C releases fragments that inhibit fibroblast migration from this molecule which, when intact, stimulates migration. In this way, proteolysis may limit fibroblast infiltration into a wound bed. Conversely, lack of proteolytic activity...
Articles
Biochem Soc Trans (2007) 35 (1): 156–160.
Published: 22 January 2007
... 801 The Arabidopsis genome also contains predicted components of the aspartate protease containing γ secretase complex [ 41 , 46 ] and seven Rhomboid class serine proteases [ 47 ], both of which have been implicated in the intramembrane proteolysis of both membrane-located ligand precursors...
Articles
Biochem Soc Trans (2005) 33 (5): 1123–1125.
Published: 26 October 2005
... a prerequisite for the octarepeat region in the N-terminus of the protein. Significantly, two disease-associated mutants of PrP, namely PG14 and A116V (Ala 116 →Val), were unable to undergo β-cleavage and this lack of proteolysis was accompanied by functional consequences in cells expressing these mutant...
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Biochem Soc Trans (2004) 32 (4): 606–610.
Published: 01 August 2004
... © 2004 The Biochemical Society 2004 apoptosis eukaryotic initiation factor (eIF) mRNA protein synthesis proteolysis translation inhibition Protein synthesis can be conveniently subdivided into three phases: initiation, elongation and termination. It is now clear...
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Biochem Soc Trans (2004) 32 (1): 33–36.
Published: 01 February 2004
... 2004 Alzheimer's disease amyloidogenesis cholesterol glycosylation lovastatin proteolysis β-secretase Abbreviations used: Aβ, β-amyloid; APP, Alzheimer's amyloid precursor protein; APPswe, Swedish mutant of APP; ASP-2, aspartic protease 2; FCS, fetal calf serum; Endo H...
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Biochem Soc Trans (2003) 31 (3): 723–727.
Published: 01 June 2003
... and possible exploitation as therapeutic targets. The Behaviour of Enzymes in Cells 723 Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries A.J. Turner1 Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K...
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Biochem Soc Trans (2001) 29 (4): 427–430.
Published: 01 August 2001
..., protein degradation serves as an important mechanism for acclimation of the Key words: chloroplast, DegP, RsH, proteolysis. Abbreviations used: PS II, photosystem II; RISP, Rieske Fe-S protein. 'To whom correspondence should be addressed (e-mail zach@agri.huji.ac.il). photosynthetic machinery to changes...
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Biochem Soc Trans (2001) 29 (4): 431–436.
Published: 01 August 2001
... functions during the biogenesis of mitochondria. Their activity is modulated by another membrane-protein complex that is composed of prohibitins. Peptides generated upon proteolysis in the matrix space are transported across the inner membrane by an ATP-binding cassette transporter. The function...