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Keywords: proteoglycan
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Articles
Biochem Soc Trans (2018) 46 (6): 1505–1515.
Published: 31 October 2018
... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antibiotics infection malaria proteoglycan Glycans represent one of the most diverse classes of biological macromolecules. They are a major part of the biomass of every organism...
Articles
Biochem Soc Trans (2018) 46 (4): 789–796.
Published: 22 June 2018
..., heterogeneous polysaccharides displayed on proteoglycans that bind various ligands, including cell surface proteins expressed on Leishmania promastigote and amastigote parasites. The fine chemical structure of HS is formed by a plethora of specific enzymes during biosynthesis, with various positions (N-, 2-O...
Articles
Biochem Soc Trans (2018) 46 (2): 371–377.
Published: 09 March 2018
...Rafael S. Aquino; Yvonne Hui-Fang Teng; Pyong Woo Park Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis. Loss of Sdc1 in mice is a gain-of-function mutation...
Articles
Biochem Soc Trans (2017) 45 (1): 173–181.
Published: 15 February 2017
... that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling. Many ECM components are proteoglycans (PGs...
Articles
Biochem Soc Trans (2006) 34 (3): 422–426.
Published: 22 May 2006
...A.E.I. Proudfoot Chemokines exert their biological activity through high-affinity interactions with cell-surface receptors, thereby activating specific signalling pathways, and a second low-affinity interaction with proteoglycans. Proteoglycans consist of a protein core, to which GAG...
Articles
Biochem Soc Trans (2006) 34 (3): 409–413.
Published: 22 May 2006
...B. Mulloy; C.C. Rider The defining characteristic of the glycoproteins known as proteoglycans is the presence of O-linked acidic polysaccharides known as GAGs (glycosaminoglycans). The backbone of these linear polysaccharides is a repeating disaccharide, comprising N -acetyl hexosamine alternating...
Articles
Biochem Soc Trans (2006) 34 (3): 451–453.
Published: 22 May 2006
...S.E. Stringer The presence of HS (heparan sulphate) proteoglycans on the cell surface and in the extracellular environment is critical to many physiological processes including the growth of new blood vessels from pre-existing vasculature (angiogenesis). A plethora of growth factors...
Articles
Biochem Soc Trans (2003) 31 (2): 340–342.
Published: 01 April 2003
... 2003 glucosaminyl N-deacetylase/N-sulphotransferase heparan sulphate heparan sulphate biosynthesis knockout mice proteoglycan Abbreviations used: HS, heparan sulphate; NDST, glucosaminyl N-deacetylase/N-sulphotransferase. 340 Biochemical Society Transactions (2003) Volume 31...
Articles
Biochem Soc Trans (2003) 31 (2): 352–353.
Published: 01 April 2003
... 22 November 2002 Copyright 2003 Biochemical Society 2003 cancer dermatan sulphate glycosaminoglycan heparan sulphate hepatocyte growth factor/scatter factor proteoglycan Abbreviations used: DS; dermatan sulphate; GAG; glycosaminoglycan; HGF; hepatocyte growth factor; HS...
Articles
Biochem Soc Trans (2002) 30 (6): 864–869.
Published: 01 November 2002
... collagen innervation intervertebral disc proteoglycan vascularization Biochemical Society Transactions (2002) Volume 30, part 6 37 38 39 40 4 I 42 43 Postacchini, F., Bellocci. M. A. and Massobrio, M. (1984) Spine 9, 596-603 Razaq, S.. Urban, J. P. and Wilkins. R. J. (2000) Cell. Physiol. Biochem...
Articles
Biochem Soc Trans (2001) 29 (2): 171–176.
Published: 01 May 2001
...T. M. Rogalski; G. P. Mullen; J. A. Bush; E. J. Gilchrist; D. G. Moerman The unc-52 gene encodes the nematode homologue of mammalian perlecan, the major heparan sulphate proteoglycan of the extracellular matrix. This is a large complex protein with regions similar to low-density lipoprotein...
Articles
Biochem Soc Trans (2001) 29 (2): 177–181.
Published: 01 May 2001
... heparanome proteoglycan sulphotransferase HS, heparan sulphate HSPG, HS proteoglycan FGF, fibroblast growth factor FGFR, FGF receptor NDST, N-deacetylase-N-sulphotransferase 6OST, 6-O-sulphotransferase 2OST, 2-O-sulphotransferase The Glycobiology of Development Dynamic biosynthesis...