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Keywords: protein synthesis
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Articles
Biochem Soc Trans (2019) 47 (5): 1429–1436.
Published: 24 September 2019
... ) * Current address: Al-Nahain University, Forensic DNA for Research and Training Center, Baghdad, Iraq © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 human mitochondria mitoribosome protein synthesis RNA translation 29 7 2019...
Articles
Biochem Soc Trans (2018) 46 (5): 1239–1246.
Published: 09 October 2018
... demands of the cell. Correspondence: Aleksandra Filipovska ( aleksandra.filipovska@uwa.edu.au ) 5 8 2018 29 8 2018 30 8 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 protein synthesis RNA-binding proteins RNA...
Articles
Biochem Soc Trans (2015) 43 (6): 1234–1240.
Published: 27 November 2015
... stress response inhibitor (ISRIB) protein synthesis vanishing white matter The initiation of eukaryotic protein synthesis is a multi-step process requiring a large number of initiation factors. The function of these factors is to recruit mRNAs to the 40S ribosomal subunit, mediate the scanning...
Articles
Biochem Soc Trans (2015) 43 (6): 1266–1270.
Published: 27 November 2015
...Estelle Dacheux; Helena Firczuk; John E.G. McCarthy Yeast commits approximately 76% of its energy budget to protein synthesis and the efficiency and control of this process are accordingly critical to organism growth and fitness. We now have detailed genetic, biochemical and biophysical knowledge...
Articles
Biochem Soc Trans (2015) 43 (3): 328–332.
Published: 01 June 2015
..., the stage in mRNA translation that consumes almost all the energy and amino acids consumed by protein synthesis. In addition to activation by Ca/CaM, eEF2K is also regulated by an array of other regulatory inputs, which include inhibition by the nutrient- and growth-factor activated signalling pathways...
Articles
Biochem Soc Trans (2015) 43 (3): 333–337.
Published: 01 June 2015
... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies...
Articles
Biochem Soc Trans (2014) 42 (1): 173–176.
Published: 23 January 2014
.... Oughtred R. Dolinski K. Barreto K. Tyers M. The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update Database 2013 2013 bat026 21 Aoyagi Y. Tasaki I. Okumura J. Muramatsu T. Energy cost of whole-body protein synthesis...
Articles
Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
... compilation © 2014 Biochemical Society 2014 gene expression mRNA protein synthesis systems biology translation mRNA translation is a key regulatory step in the control of gene expression and protein synthesis. The field itself covers many aspects, including, but not limited to: (i...
Articles
Biochem Soc Trans (2012) 40 (1): 168–172.
Published: 19 January 2012
..., cell growth and cell division. We have studied the impact of inhibiting mTOR on protein synthesis in human cells. Partial inhibition of mTORC1 by rapamycin has only a limited impact on protein synthesis, but inhibiting mTOR kinase activity causes much greater inhibition of protein synthesis. Using...
Articles
Biochem Soc Trans (2011) 39 (2): 658–662.
Published: 22 March 2011
...Marina V. Rodnina; Wolfgang Wintermeyer Translocation of tRNA and mRNA through the ribosome is one of the most dynamic events during protein synthesis. In the cell, translocation is catalysed by EF-G (elongation factor G) and driven by GTP hydrolysis. Major unresolved questions are: how...
Articles
Biochem Soc Trans (2010) 38 (6): 1523–1526.
Published: 24 November 2010
... factor Ts from bovine and human liver J. Biol. Chem. 1995 270 17243 17249 10 Woriax V.L. Burkhart W. Spremulli L.L. Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu Biochim. Biophys. Acta 1995 1264 347 356 11...
Articles
Biochem Soc Trans (2009) 37 (6): 1298–1310.
Published: 19 November 2009
...Graham D. Pavitt; Christopher G. Proud Protein synthesis (also termed mRNA translation) is a key step in the expression of a cell's genetic information, in which the information contained within the coding region of the mRNA is used to direct the synthesis of the new protein, a process...
Articles
Biochem Soc Trans (2009) 37 (1): 227–231.
Published: 20 January 2009
...Christopher G. Proud Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth...
Articles
Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
... compilation © 2008 Biochemical Society 2008 gene expression in vitro -transcribed RNA microRNA (miRNA) polysomes protein synthesis translation miRNAs (microRNAs) are a class of recently discovered 21–25 nucleotide RNA molecules, which bind with imperfect complementarity to their target...
Articles
Biochem Soc Trans (2008) 36 (4): 684–689.
Published: 22 July 2008
... strategy is capable of generating a large number of stable three-dimensional folds that display a diverse range of highly specific functions in a variety of biological processes. The present review focuses on pseudoknots that act in the regulation of protein synthesis using cellular and viral examples...
Articles
Biochem Soc Trans (2007) 35 (5): 1314–1316.
Published: 25 October 2007
...M.G. MacKenzie; D.L. Hamilton; J.T. Murray; K. Baar Resistance-exercise training results in a progressive increase in muscle mass and force production. Following an acute bout of resistance exercise, the rate of protein synthesis increases proportionally with the increase in protein degradation...
Articles
Biochem Soc Trans (2006) 34 (4): 600–604.
Published: 21 July 2006
... and protein synthesis, a process referred to as synaptic consolidation. Several lines of evidence have implicated endogenous BDNF–TrkB signalling in synaptic consolidation. This mini-review emphasizes new insights into the molecular mechanisms underlying this process. The immediate early gene Arc (activity...
Articles
Biochem Soc Trans (2006) 34 (2): 328–329.
Published: 20 March 2006
... 2006 directed evolution gene regulatory circuit genetic code protein synthesis ribosome–mRNA pair synthetic biology The ribosome is a 2.5 MDa molecular machine that converts the information encoded in mRNA into protein [ 1 ]. In bacterial cells, the ribosome is most commonly directed...
Articles
Biochem Soc Trans (2006) 34 (1): 12–16.
Published: 20 January 2006
...T.L. Hamilton; M. Stoneley; K.A. Spriggs; M. Bushell Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is reduced significantly. In mammalian cells, this effect is achieved in part through a co-ordinated inhibition of RP (ribosomal protein) synthesis. More...
Articles
Biochem Soc Trans (2005) 33 (6): 1483–1486.
Published: 26 October 2005
...@nottingham.ac.uk ). 27 6 2005 © 2005 The Biochemical Society 2005 artificial internal ribosome entry segment (artificial IRES) internal ribosome entry segment (IRES) internal ribosome entry segment trans -acting factor (ITAF) polypyrimidine tract-binding protein (PTB) protein synthesis...
Articles
Biochem Soc Trans (2004) 32 (4): 606–610.
Published: 01 August 2004
...M. Bushell; M. Stoneley; P. Sarnow; A.E. Willis The induction of apoptosis leads to a substantial inhibition of protein synthesis. During this process changes to the translation-initiation factors, the ribosome and the cellular level of mRNA have been documented. However, it is by no means clear...
Articles
Biochem Soc Trans (2003) 31 (1): 213–215.
Published: 01 February 2003
... Protein Kinase, a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 apoptosis glycolysis Pasteur Effect protein synthesis Abbreviations used: AMPK, AMP-activated...
Articles
Biochem Soc Trans (2002) 30 (2): 133–140.
Published: 01 April 2002
...V. Márquez; D. N. Wilson; K. H. Nierhaus The ribosome translates the genetic information of an mRNA molecule into a sequence of amino acids. The ribosome utilizes tRNAs to connect elements of the RNA and protein worlds during protein synthesis, i.e. an anticodon as a unit of genetic information...
Articles
Biochem Soc Trans (2001) 29 (4): 541–547.
Published: 01 August 2001
...C. G. Proud; X. Wang; J. V. Patel; L. E. Campbell; M. Kleijn; W. Li; G. J. Browne Protein synthesis in mammalian cells is regulated through alterations in the states of phosphorylation of eukaryotic initiation factors and elongation factors (eIFs and eEFs respectively) and of other regulatory...