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Keywords: protein structure
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Articles
Biochem Soc Trans (2023) BST20220611.
Published: 20 January 2023
... membrane proteins Mycobacterium tuberculosis protein structure Bacteria of the genus Mycobacterium include pathogenic species such as M. tuberculosis , M. leprae , M. avium , M. abscessus (sometimes called Mycobacteroides abscessus ), and M. ulcerans, as well as non-pathogenic species...
Articles
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
... 2022 biosynthesis coenzymes cofactors nickel protein structure racemase Lactate racemase (Lar) interconverts the l - and d -isomers of lactic acid ( Figure 1A ) [ 1 ]. These 2-hydroxyacids are products of microbial fermentation and have numerous applications in the pharmaceutical...
Articles
Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... binding parameters and pathway profiles are predicted to be more highly functionally interchangeable and to present promising repurposing opportunities. computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure The field...
Articles
Biochem Soc Trans (2022) 50 (1): 541–554.
Published: 07 February 2022
... protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... and membrane protein studies, which uniquely provides information on structure, interactions and dynamics of membrane proteins. High resolution approaches are discussed in conjunction with applications of NMR methods to studies of membrane lipid and protein structure and interactions. Signal enhancement...
Articles
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...
Articles
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
... (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. ion mobility mass spectrometry protein structure...
Articles
Biochem Soc Trans (2020) 48 (6): 2615–2624.
Published: 10 November 2020
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. protein structure ring ligases TRIM proteins ubiquitin ligases An abundance of cellular functions is controlled by the attachment of a 76-residue ubiquitin (Ub) molecule to a protein...
Includes: Supplementary data
Articles
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
... (CC BY) . Open access for this article was enabled by the participation of University of Groningen in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. membrane proteins protein structure transport Importance of the field. Since the first...
Articles
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
... BY-NC-ND) . AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T ransport (ESCRT) pathways drive membrane fission in numerous cellular processes, including cytokinesis, multivesicular...
Articles
Biochem Soc Trans (2019) 47 (1): 433–440.
Published: 21 December 2018
...(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . function membrane lipid oligomerisation protein structure transporter Integral membrane...
Articles
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
... 2019 drug discovery membrane proteins protein structure structure–function relationship Membrane proteins (MP) are a large multigene family comprising around a quarter of the encoding genes in the human genome [ 1 , 2 ]. Represented by transporters, receptors, enzymes and cell adhesion...
Articles
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( anirban.banerjee@nih.gov ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins Of all...
Articles
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
...]. The structural basis of CF will be discussed in this article. cystic fibrosis transmembrane conductance regulator ion channel protein structure transmembrane proteins NMR was also employed to study the interactions of the third soluble ‘domain’ in CFTR, the 200 residue-long Regulatory-region or R...
Articles
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . membrane proteins protein engineering protein stability protein structure Integral membrane proteins (IMPs) exist within lipid membranes. Current estimates suggest that between 15 and 30% of open...
Articles
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... on the available OGT inhibitors and summarizes advantages, limitations and future challenges. © 2016 Authors; published by Portland Press Limited 2016 inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein...
Articles
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
...; published by Portland Press Limited 2015 bioinformatics protein structure proteome scoring function tandem repeats Next-generation sequencing platforms are revolutionizing life sciences, medicine and agriculture. A huge number of newly sequenced genomes from a wide range of species...
Articles
Biochem Soc Trans (2015) 43 (5): 1033–1040.
Published: 09 October 2015
... ). 3 6 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 . ATP-binding cassette (ABC) transporter disease multi-drug resistance protein structure transport mechanism...
Articles
Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... the ability to bind a protein can result from very subtle sequence changes. 1 email andrew@bioinf.org.uk 4 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure...
Articles
Biochem Soc Trans (2014) 42 (2): 479–484.
Published: 20 March 2014
... activation metalloenzyme protein structure Glo1 (glyoxalase I) [also termed GloA or GlxI; S - D -lactoylglutathione methylglyoxal lyase (isomerizing); EC 4.4.1.5] is the first of two enzymes of the glyoxalase enzyme system ( Figure 1 ) which converts MG (methylglyoxal) into D -lactate [ 1 , 2...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2012) 40 (6): 1295–1301.
Published: 21 November 2012
...) protein structure The first Geobacter strain described in the literature was isolated in 1987 from freshwater sediments. Since then, numerous physiological and genetic studies have revealed the respiratory versatility and environmental relevance of Geobacter species in natural habitats...
Includes: Supplementary data
Articles
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
..., as changes at the end are less likely to disrupt the protein's structure (see pp. 751–755). They also trace the evolution of the immunoglobulin superfamily through 500 million years from its origins in the cell receptor proteins of primitive sponges to their current status as one of the largest families...
Articles
Biochem Soc Trans (2009) 37 (4): 727–733.
Published: 22 July 2009
... considerable sequence divergence so that sequence similarities were in the twilight zone (20–35% identity) and below. Indeed, analyses of existing protein structures and sequences provided an approach not only to understand the structure and function of proteins, but also to solving the inverse folding problem...
Articles
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
..., including Mastermind (MAM), and initiating transcription in the receiving cell [ 22 ]. ankyrin repeat intrinsic disorder Notch signalling protein–protein interaction protein structure In addition to the CSL transcription factor, MAM and other nuclear co-activators and co-repressors...
Articles
Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
... 2006 docking heparan sulphate heparin protein structure protein surface simulated annealing Initial validation exercises were performed using FGF-2 [ 11 ], FGF-1 ( Figure 1 ) and antithrombin. In all these cases, docking a ligand prepared from the NMR structure 1HPN, together...
Articles
Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
... for further details. 1 email ferguso2@mail.med.upenn.edu 23 7 2004 © 2004 The Biochemical Society 2004 ErbB receptor extracellular domain growth factor mechanism-based inhibitor protein structure target-specific drug The correlation between EGFR and cancer is well...
Articles
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... © 2001 Biochemical Society 2001 amyloid-β peptide α-helix → β-strand transition prion protein protein structure secondary structure prediction Aβ, amyloid-β ES, electrospray PAP, pulmonary alveolar proteinosis PrP, prion protein SP-C, surfactant protein C DPPC...
Articles
Biochem Soc Trans (2000) 28 (2): 264–269.
Published: 01 February 2000
... of the algorithm, it will be possible to compare all of these against the Protein Structure Database and determine the extent to which the current ideal forms can account for the variety of protein structure. Analysis of the remainder should provide a base for the development of further forms. 1 9 1999...