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Keywords: protein structure
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Articles
Biochem Soc Trans (2023) 51 (5): 1907–1919.
Published: 18 September 2023
... though binding with HMGB2, a non-histone DNA interacting protein. Such subcellular localisation of Cygb under oxidative conditions has interesting implications for cancer research and lipid signalling in the nucleus. cytoglobin disulphide bonds protein structure redox chemistry Cytoglobin...
Articles
Biochem Soc Trans (2023) 51 (3): 1257–1269.
Published: 24 May 2023
... transcription protein structure Sen1 Transcription in animal/fungal cells is performed by three RNA polymerases, with RNA Pol II dealing with mRNAs and some non-coding RNAs (ncRNAs) [ 1 , 2 ]. RNA polymerases employ different termination pathways [ 3–5 ]. In the case of RNA Pol II transcription...
Includes: Supplementary data
Articles
Biochem Soc Trans (2023) 51 (2): 855–869.
Published: 21 April 2023
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . caveolae caveolins cell membranes cryo-electron microscopy membrane proteins protein structure Nanoscale flask-shaped...
Articles
Biochem Soc Trans (2023) 51 (1): 183–193.
Published: 20 January 2023
... chain membrane proteins Mycobacterium tuberculosis protein structure Bacteria of the genus Mycobacterium include pathogenic species such as M. tuberculosis , M. leprae , M. avium , M. abscessus (sometimes called Mycobacteroides abscessus ), and M. ulcerans, as well as non-pathogenic...
Articles
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
... of a cyclometallase. This protein also is unusual in being a single-turnover CTP-dependent enzyme [ 38 ]. biosynthesis coenzymes cofactors nickel protein structure racemase Figure 3. Structure and alternative mechanisms of LarE. ( A ) LarE Lp -catalyzed biosynthesis of P2TMN from P2CMN...
Articles
Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... Society 2022 computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other...
Articles
Biochem Soc Trans (2022) 50 (1): 541–554.
Published: 07 February 2022
... protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... and membrane protein studies, which uniquely provides information on structure, interactions and dynamics of membrane proteins. High resolution approaches are discussed in conjunction with applications of NMR methods to studies of membrane lipid and protein structure and interactions. Signal enhancement...
Articles
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... plants, where they are also sometimes called vacuolar processing enzymes due to their localisation in vacuoles and their role in processing vacuolar proteins [ 1 , 5 ]. peptides plant proteins protein structure proteolysis © 2021 The Author(s) 2021 This is an open access article...
Articles
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
... (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. ion mobility mass spectrometry protein structure...
Articles
Biochem Soc Trans (2020) 48 (6): 2615–2624.
Published: 10 November 2020
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. protein structure ring ligases TRIM proteins ubiquitin ligases An abundance of cellular functions is controlled by the attachment of a 76-residue ubiquitin (Ub) molecule to a protein...
Includes: Supplementary data
Articles
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
... by the participation of University of Groningen in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. membrane proteins protein structure transport Structural studies of membrane transporters from diverse protein families have revealed that alternating access...
Articles
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
.... Biol. 25 , 616 – 622 10.1038/s41594-018-0085-x AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T ransport (ESCRT) pathways drive membrane fission in numerous cellular...
Articles
Biochem Soc Trans (2019) 47 (1): 433–440.
Published: 21 December 2018
...(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . function membrane lipid oligomerisation protein structure transporter Integral membrane...
Articles
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( anirban.banerjee@nih.gov ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins Of all...
Articles
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
... 2019 drug discovery membrane proteins protein structure structure–function relationship Finally, the NPxxY motif located in the cytoplasmic end of the TM7 (see Figure 1c ) seems to play an important role in GPCR activation [ 37 , 38 ]. Available structural data have also...
Articles
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... conductance regulator ion channel protein structure transmembrane proteins R.C.F. wrote the paper. X.M., J.C., A.D.C. and E.R.M. discussed and edited the manuscript and contributed to the concepts therein. The authors acknowledge the Cystic Fibrosis Foundation [CFF FORD13XX0] and the Cystic...
Articles
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
... organisms Protein Sci. 1998 7 1029 1038 10.1002/pro.5560070420 9568909 3 Bill R. Henderson P. Iwata S. Kunji E. Michel H. Neutze R. Newstead S. Poolman B. Tate C. Vogel H. Overcoming barriers to membrane protein structure determination Nat...
Articles
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... 2016 inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Protein O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification is characterized...
Articles
Biochem Soc Trans (2015) 43 (5): 1033–1040.
Published: 09 October 2015
... ). 3 6 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 . ATP-binding cassette (ABC) transporter disease multi-drug resistance protein structure transport mechanism...
Articles
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
... protein structures and functions [ 9 , 10 ]. Once appeared and fixed among populations, these perfectly repetitive regions start to accumulated mutations (insertions, deletions and single amino acid substitutions). One can imagine that the evolutionary scenarios of TR regions folded in the stable 3D...
Articles
Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure The traditional dogma of biology has been that DNA is copied into RNA which encodes a protein with a single function. Over the last 10–15 years, this dogma has...
Articles
Biochem Soc Trans (2014) 42 (2): 479–484.
Published: 20 March 2014
... © 2014 Biochemical Society 2014 Clostridium acetobutylicum Escherichia coli glyoxalase metal activation metalloenzyme protein structure The finding that a non-Zn 2+ -activated Glo1 existed allowed for the speculation that other Glo1 might also exhibit...
Includes: Multimedia, Supplementary data
Articles
Articles
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
..., as changes at the end are less likely to disrupt the protein's structure (see pp. 751–755). They also trace the evolution of the immunoglobulin superfamily through 500 million years from its origins in the cell receptor proteins of primitive sponges to their current status as one of the largest families...
Articles
Biochem Soc Trans (2009) 37 (4): 727–733.
Published: 22 July 2009
.... Subsequent analyses of more divergent members of superfamilies showed that these general features could still be preserved while allowing considerable sequence divergence so that sequence similarities were in the twilight zone (20–35% identity) and below. Indeed, analyses of existing protein structures...
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Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
..., at Laboratory for Molecular Structure, NIBSC (email bmulloy@nibsc.ac.uk ). 19 12 2005 © 2006 The Biochemical Society 2006 docking heparan sulphate heparin protein structure protein surface simulated annealing The complex glycosaminoglycan HS (heparan sulphate) [ 1 ] is found...
Articles
Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
... inhibitor protein structure target-specific drug Recent structural data have led to the proposal of a novel model for the ligand-induced dimerization and activation of the EGFR (epidermal growth factor receptor) family of RTKs (receptor tyrosine kinases) (Figure 1 ) [ 1 – 4 ]. Growth factor...
Articles
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... © 2001 Biochemical Society 2001 amyloid-β peptide α-helix → β-strand transition prion protein protein structure secondary structure prediction Aβ, amyloid-β ES, electrospray PAP, pulmonary alveolar proteinosis PrP, prion protein SP-C, surfactant protein C DPPC...
Articles
Biochem Soc Trans (2000) 28 (2): 264–269.
Published: 01 February 2000
... of the algorithm, it will be possible to compare all of these against the Protein Structure Database and determine the extent to which the current ideal forms can account for the variety of protein structure. Analysis of the remainder should provide a base for the development of further forms. 1 9 1999...