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Keywords: protein structure
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Articles
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
... 2022 biosynthesis coenzymes cofactors nickel protein structure racemase Lactate racemase (Lar) interconverts the l - and d -isomers of lactic acid ( Figure 1A ) [ 1 ]. These 2-hydroxyacids are products of microbial fermentation and have numerous applications in the pharmaceutical...
Articles
Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... Society 2022 computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other...
Articles
Biochem Soc Trans (2022) 50 (1): 541–554.
Published: 07 February 2022
... protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... ) or Fasséli Coulibaly ( fasseli.coulibaly@monash.edu ) 8 11 2021 6 1 2022 12 1 2022 bacteriophages cryo-electron microscopy protein structure structural biology virology The defining characteristic of Siphoviridae -like phages is the long non-contractile tubular tail...
Articles
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... and membrane protein studies, which uniquely provides information on structure, interactions and dynamics of membrane proteins. High resolution approaches are discussed in conjunction with applications of NMR methods to studies of membrane lipid and protein structure and interactions. Signal enhancement...
Articles
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...
Articles
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
... (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. ion mobility mass spectrometry protein structure...
Articles
Biochem Soc Trans (2020) 48 (6): 2615–2624.
Published: 10 November 2020
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. protein structure ring ligases TRIM proteins ubiquitin ligases An abundance of cellular functions is controlled by the attachment of a 76-residue ubiquitin (Ub) molecule to a protein...
Includes: Supplementary data
Articles
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. membrane proteins protein structure transport Correspondence: Dirk J. Slotboom ( d.j.slotboom@rug.nl ) The concentrative nucleoside transporter CNT (a member of the SLC28 family...
Articles
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
..., understanding of Vps4 structure and mechanism has been a high priority since the discovery of its importance in the ESCRT pathway that buds vesicles into multivesicular bodies [ 9 ]. AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure For many years...
Articles
Biochem Soc Trans (2019) 47 (1): 433–440.
Published: 21 December 2018
...(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . function membrane lipid oligomerisation protein structure transporter Integral membrane...
Articles
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( anirban.banerjee@nih.gov ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins Of all...
Articles
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
... 2019 drug discovery membrane proteins protein structure structure–function relationship Membrane proteins (MP) are a large multigene family comprising around a quarter of the encoding genes in the human genome [ 1 , 2 ]. Represented by transporters, receptors, enzymes and cell adhesion...
Articles
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... transmembrane conductance regulator ion channel protein structure transmembrane proteins CFTR is a member of the ATP-binding cassette (ABC) family of proteins [ 1 – 3 ]. As such, CFTR has the standard four-domain structure consisting of two transmembrane domains and two soluble nucleotide-binding...
Articles
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . membrane proteins protein engineering protein stability protein structure Integral membrane proteins (IMPs) exist within lipid membranes. Current estimates suggest that between 15 and 30% of open...
Articles
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... 2016 inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Protein O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification is characterized...
Articles
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
...; published by Portland Press Limited 2015 bioinformatics protein structure proteome scoring function tandem repeats Thus, among the above scoring procedures, only P sim can assess the pre-established MSA. In addition, several other scoring functions for assessment of TR MSAs were...
Articles
Biochem Soc Trans (2015) 43 (5): 1033–1040.
Published: 09 October 2015
... ). 3 6 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 . ATP-binding cassette (ABC) transporter disease multi-drug resistance protein structure transport mechanism...
Articles
Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... as ‘catalytic promiscuity’ rather than true moonlighting), or that functions belong to different biological processes in GO. So how does moonlighting relate to protein structure? Proteins consist of one or more domains. Figure 1 also illustrates this. The antibody heavy chains each have four structural...
Articles
Biochem Soc Trans (2014) 42 (2): 479–484.
Published: 20 March 2014
... Biochemical Society 2014 Clostridium acetobutylicum Escherichia coli glyoxalase metal activation metalloenzyme protein structure Glo1 (glyoxalase I) [also termed GloA or GlxI; S - D -lactoylglutathione methylglyoxal lyase (isomerizing); EC 4.4.1.5] is the first of two enzymes...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2012) 40 (6): 1295–1301.
Published: 21 November 2012
... ] and new strategies towards the investigation of these proteins can now be developed. extracellular electron transfer Geobacter sulfurreducens multihaem cytochrome nuclear magnetic resonance (NMR) protein structure The first Geobacter strain described in the literature was isolated...
Includes: Supplementary data
Articles
Biochem Soc Trans (2009) 37 (4): 727–733.
Published: 22 July 2009
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. buried residue hydrogen bond local structural environment protein evolution protein structure An understanding...
Articles
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
..., as changes at the end are less likely to disrupt the protein's structure (see pp. 751–755). They also trace the evolution of the immunoglobulin superfamily through 500 million years from its origins in the cell receptor proteins of primitive sponges to their current status as one of the largest families...
Articles
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
... be addressed (email barrick@jhu.edu ). 28 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 ankyrin repeat intrinsic disorder Notch signalling protein–protein interaction protein structure The Notch pathway is a transmembrane signal transduction pathway...
Articles
Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
..., at Laboratory for Molecular Structure, NIBSC (email bmulloy@nibsc.ac.uk ). 19 12 2005 © 2006 The Biochemical Society 2006 docking heparan sulphate heparin protein structure protein surface simulated annealing The complex glycosaminoglycan HS (heparan sulphate) [ 1 ] is found...
Articles
Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
... Montfort, Leicester, U.K.), J. Mayer (Nottingham, U.K.) and M. Tuite (Canterbury, U.K.). ErbB receptor extracellular domain growth factor mechanism-based inhibitor protein structure target-specific drug EGF(R) epidermal growth factor (receptor) sEGFR extracellular region of EGFR...
Articles
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... © 2001 Biochemical Society 2001 amyloid-β peptide α-helix → β-strand transition prion protein protein structure secondary structure prediction Aβ, amyloid-β ES, electrospray PAP, pulmonary alveolar proteinosis PrP, prion protein SP-C, surfactant protein C DPPC...
Articles
Biochem Soc Trans (2000) 28 (2): 264–269.
Published: 01 February 2000
... of the algorithm, it will be possible to compare all of these against the Protein Structure Database and determine the extent to which the current ideal forms can account for the variety of protein structure. Analysis of the remainder should provide a base for the development of further forms. 1 9 1999...