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Keywords: protein structure
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Articles
Biochem Soc Trans (2023) BST20221418.
Published: 24 May 2023
... domain SD split domain TRAMP Trf4/5 Air1/2 Mtr4 polyadenylation complex CUTs Nab3 Nrd1 pervasive transcription protein structure Sen1 References 1 Kuehner , J.N. , Pearson , E.L. and Moore , C. ( 2011 ) Unravelling the means to an end: RNA...
Articles
Biochem Soc Trans (2023) 51 (2): 855–869.
Published: 21 April 2023
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . caveolae caveolins cell membranes cryo-electron microscopy membrane proteins protein structure A critical step forward...
Articles
Biochem Soc Trans (2023) 51 (1): 183–193.
Published: 20 January 2023
... chain membrane proteins Mycobacterium tuberculosis protein structure Bacteria of the genus Mycobacterium include pathogenic species such as M. tuberculosis , M. leprae , M. avium , M. abscessus (sometimes called Mycobacteroides abscessus ), and M. ulcerans, as well as non-pathogenic...
Articles
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
.... Thus, lactate racemase is the founding member of a large family of NPN-containing enzymes. biosynthesis coenzymes cofactors nickel protein structure racemase Lactate racemase (Lar) interconverts the l - and d -isomers of lactic acid ( Figure 1A ) [ 1 ]. These 2-hydroxyacids...
Articles
Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other conditions that are already known to be largely safe...
Articles
Biochem Soc Trans (2022) 50 (1): 541–554.
Published: 07 February 2022
... protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... and membrane protein studies, which uniquely provides information on structure, interactions and dynamics of membrane proteins. High resolution approaches are discussed in conjunction with applications of NMR methods to studies of membrane lipid and protein structure and interactions. Signal enhancement...
Articles
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...
Articles
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
... (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. ion mobility mass spectrometry protein structure...
Articles
Biochem Soc Trans (2020) 48 (6): 2615–2624.
Published: 10 November 2020
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. protein structure ring ligases TRIM proteins ubiquitin ligases An abundance of cellular functions is controlled by the attachment of a 76-residue ubiquitin (Ub) molecule to a protein...
Includes: Supplementary data
Articles
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
... by the participation of University of Groningen in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. membrane proteins protein structure transport Structural studies of membrane transporters from diverse protein families have revealed that alternating access...
Articles
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
... BY-NC-ND) . AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T ransport (ESCRT) pathways drive membrane fission in numerous cellular processes, including cytokinesis, multivesicular...
Articles
Biochem Soc Trans (2019) 47 (1): 433–440.
Published: 21 December 2018
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . function membrane lipid oligomerisation protein structure transporter Integral membrane transporters play key roles in the effective...
Articles
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( anirban.banerjee@nih.gov ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins DHHC-PATs...
Articles
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
... ( isabel.moraes@npl.co.uk ) 7 8 2018 22 10 2018 29 10 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 drug discovery membrane proteins protein structure structure–function relationship Membrane proteins (MP) are a large...
Articles
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
...]. The structural basis of CF will be discussed in this article. cystic fibrosis transmembrane conductance regulator ion channel protein structure transmembrane proteins Initial structural studies were carried out over a decade ago on the soluble CFTR domains studied in isolation from...
Articles
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . membrane proteins protein engineering protein stability protein structure Integral membrane proteins (IMPs) exist within lipid membranes. Current estimates suggest that between 15 and 30% of open...
Articles
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... ], rendering the enzyme inactive. inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Figure 1 Chemical structures discussed in this review UDP–5S–GlcNAc...
Articles
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
...; published by Portland Press Limited 2015 bioinformatics protein structure proteome scoring function tandem repeats Table 1 Scores used to assess TR MSAs Gaps are considered as twenty-first amino acids. Given an MSA of n repeat units, of length l , a fractional frequency can...
Articles
Biochem Soc Trans (2015) 43 (5): 1033–1040.
Published: 09 October 2015
... or ian.kerr@nottingham.ac.uk ). 3 6 2015 ATP-binding cassette (ABC) transporter disease multi-drug resistance protein structure transport mechanism The ATP-binding cassette (ABC) transporter field emerged from studies on nutrient uptake in bacteria in the 1970’s with the biochemical...
Articles
Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure The traditional dogma of biology has been that DNA is copied into RNA which encodes a protein with a single function. Over the last 10–15 years, this dogma has...
Articles
Biochem Soc Trans (2014) 42 (2): 479–484.
Published: 20 March 2014
... exist. The further investigation of the metal control of Glo1 by its protein structure continue to intrigue investigators not only for the enzyme's fundamental enzymology and the role that molecular structure plays in metal binding and activation, but also its importance in MG control and its role...
Includes: Multimedia, Supplementary data
Articles
Articles
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
... To whom correspondence should be addressed (email roman@ebi.ac.uk ). gene duplication horizontal gene transfer phosphorylation protein evolution protein network protein structure In the 150 years since On the Origin of Species [ 1 ] was published, we have learnt much about...
Articles
Biochem Soc Trans (2009) 37 (4): 727–733.
Published: 22 July 2009
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. buried residue hydrogen bond local structural environment protein evolution protein structure An understanding...
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Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
..., at Laboratory for Molecular Structure, NIBSC (email bmulloy@nibsc.ac.uk ). 19 12 2005 © 2006 The Biochemical Society 2006 docking heparan sulphate heparin protein structure protein surface simulated annealing The complex glycosaminoglycan HS (heparan sulphate) [ 1 ] is found...
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Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
...-mean-square deviation RTK receptor tyrosine kinase TGFα transforming growth factor-α ErbB receptor extracellular domain growth factor mechanism-based inhibitor protein structure target-specific drug Recent structural data have led to the proposal of a novel model...
Articles
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... © 2001 Biochemical Society 2001 amyloid-β peptide α-helix → β-strand transition prion protein protein structure secondary structure prediction Aβ, amyloid-β ES, electrospray PAP, pulmonary alveolar proteinosis PrP, prion protein SP-C, surfactant protein C DPPC...
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Biochem Soc Trans (2000) 28 (2): 264–269.
Published: 01 February 2000
... of the algorithm, it will be possible to compare all of these against the Protein Structure Database and determine the extent to which the current ideal forms can account for the variety of protein structure. Analysis of the remainder should provide a base for the development of further forms. 1 9 1999...