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Keywords: protein structure
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1907–1919.
Published: 18 September 2023
... dimerization mode . Acta Crystallogr. D Biol. Crystallogr. 62 , 671 – 677 10.1107/S0907444906013813 26 Jumper , J. , Evans , R. , Pritzel , A. , Green , T. , Figurnov , M. , Ronneberger , O. et al. ( 2021 ) Highly accurate protein structure prediction with alphaFold...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1257–1269.
Published: 24 May 2023
... transcription protein structure Sen1 Transcription in animal/fungal cells is performed by three RNA polymerases, with RNA Pol II dealing with mRNAs and some non-coding RNAs (ncRNAs) [ 1 , 2 ]. RNA polymerases employ different termination pathways [ 3–5 ]. In the case of RNA Pol II transcription...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 855–869.
Published: 21 April 2023
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . caveolae caveolins cell membranes cryo-electron microscopy membrane proteins protein structure Nanoscale flask-shaped...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 183–193.
Published: 20 January 2023
... membrane proteins Mycobacterium tuberculosis protein structure Compared to the ATP synthase, targeting other complexes involved in mycobacterial oxidative phosphorylation presents additional challenges. In the mitochondrial ETC a single complex catalyzes each redox reaction ( Figure 1A...
Articles
Shramana Chatterjee, Santhosh Gatreddi, Swati Gupta, Jorge L. Nevarez, Joel A. Rankin, Aiko Turmo, Jian Hu, Robert P. Hausinger
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
... resulted in only the C-terminal portion of the protein structure being solved due to apparent proteolysis ( Figure 4A ) [ 38 ]. This domain includes a novel CTP-binding pocket involving residues from three separate chains of the protein ( Figure 4B ). The N-terminal domain of unknown structure has...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... knowledgebase. High quality 3D protein structures can be obtained directly from the experimentally determined structures of the Protein Databank [ 7 , 8 ] where applicable, and otherwise can be modelled by a range of established methodologies that have advanced substantially in recent years, excellently...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 541–554.
Published: 07 February 2022
... protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... and membrane protein studies, which uniquely provides information on structure, interactions and dynamics of membrane proteins. High resolution approaches are discussed in conjunction with applications of NMR methods to studies of membrane lipid and protein structure and interactions. Signal enhancement...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
... (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. ion mobility mass spectrometry protein structure...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2615–2624.
Published: 10 November 2020
... conformation’ formed upon interaction with RING domains in which ubiquitin contacts the E2 and the thioester bond is primed for ubiquitin transfer. protein structure ring ligases TRIM proteins ubiquitin ligases An abundance of cellular functions is controlled by the attachment of a 76...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
... by the participation of University of Groningen in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. membrane proteins protein structure transport Structural studies of membrane transporters from diverse protein families have revealed that alternating access...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
.... Biol. 25 , 616 – 622 10.1038/s41594-018-0085-x AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T ransport (ESCRT) pathways drive membrane fission in numerous cellular...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 433–440.
Published: 21 December 2018
...(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . function membrane lipid oligomerisation protein structure transporter Integral membrane...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( anirban.banerjee@nih.gov ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins Of all...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
... 2019 drug discovery membrane proteins protein structure structure–function relationship Finally, the NPxxY motif located in the cytoplasmic end of the TM7 (see Figure 1c ) seems to play an important role in GPCR activation [ 37 , 38 ]. Available structural data have also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... conductance regulator ion channel protein structure transmembrane proteins R.C.F. wrote the paper. X.M., J.C., A.D.C. and E.R.M. discussed and edited the manuscript and contributed to the concepts therein. The authors acknowledge the Cystic Fibrosis Foundation [CFF FORD13XX0] and the Cystic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
... organisms Protein Sci. 1998 7 1029 1038 10.1002/pro.5560070420 9568909 3 Bill R. Henderson P. Iwata S. Kunji E. Michel H. Neutze R. Newstead S. Poolman B. Tate C. Vogel H. Overcoming barriers to membrane protein structure determination Nat...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... 2016 inhibitor O-linked N -acetylglucosamine (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Protein O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification is characterized...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 1033–1040.
Published: 09 October 2015
... ). 3 6 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 . ATP-binding cassette (ABC) transporter disease multi-drug resistance protein structure transport mechanism...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
... protein structures and functions [ 9 , 10 ]. Once appeared and fixed among populations, these perfectly repetitive regions start to accumulated mutations (insertions, deletions and single amino acid substitutions). One can imagine that the evolutionary scenarios of TR regions folded in the stable 3D...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure The traditional dogma of biology has been that DNA is copied into RNA which encodes a protein with a single function. Over the last 10–15 years, this dogma has...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 479–484.
Published: 20 March 2014
... © 2014 Biochemical Society 2014 Clostridium acetobutylicum Escherichia coli glyoxalase metal activation metalloenzyme protein structure The finding that a non-Zn 2+ -activated Glo1 existed allowed for the speculation that other Glo1 might also exhibit...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1295–1301.
Published: 21 November 2012
...) protein structure The first Geobacter strain described in the literature was isolated in 1987 from freshwater sediments. Since then, numerous physiological and genetic studies have revealed the respiratory versatility and environmental relevance of Geobacter species in natural habitats...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
..., as changes at the end are less likely to disrupt the protein's structure (see pp. 751–755). They also trace the evolution of the immunoglobulin superfamily through 500 million years from its origins in the cell receptor proteins of primitive sponges to their current status as one of the largest families...
Articles
Sungsam Gong, Catherine L. Worth, G. Richard J. Bickerton, Semin Lee, Duangrudee Tanramluk, Tom L. Blundell
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 727–733.
Published: 22 July 2009
.... Subsequent analyses of more divergent members of superfamilies showed that these general features could still be preserved while allowing considerable sequence divergence so that sequence similarities were in the twilight zone (20–35% identity) and below. Indeed, analyses of existing protein structures...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
... be addressed (email barrick@jhu.edu ). 28 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 ankyrin repeat intrinsic disorder Notch signalling protein–protein interaction protein structure The Notch pathway is a transmembrane signal transduction pathway...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
..., at Laboratory for Molecular Structure, NIBSC (email bmulloy@nibsc.ac.uk ). 19 12 2005 © 2006 The Biochemical Society 2006 docking heparan sulphate heparin protein structure protein surface simulated annealing The complex glycosaminoglycan HS (heparan sulphate) [ 1 ] is found...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
... inhibitor protein structure target-specific drug Recent structural data have led to the proposal of a novel model for the ligand-induced dimerization and activation of the EGFR (epidermal growth factor receptor) family of RTKs (receptor tyrosine kinases) (Figure 1 ) [ 1 – 4 ]. Growth factor...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... © 2001 Biochemical Society 2001 amyloid-β peptide α-helix → β-strand transition prion protein protein structure secondary structure prediction Aβ, amyloid-β ES, electrospray PAP, pulmonary alveolar proteinosis PrP, prion protein SP-C, surfactant protein C DPPC...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 264–269.
Published: 01 February 2000
... of the algorithm, it will be possible to compare all of these against the Protein Structure Database and determine the extent to which the current ideal forms can account for the variety of protein structure. Analysis of the remainder should provide a base for the development of further forms. 1 9 1999...
