... of substrates and novel pathways and substrates that utilize its activity. Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. VCP...

... protein misfolding protein quality control ubiquitin ubiquitin proteasome system The proper functioning of proteins in cells is critical for all forms of life. Proteins serve as the molecular machines that facilitate a wide array of life-giving processes. The normal cellular function...

... adding to the complexity of its role in protein quality control. Central to the activities of both SGTA and the BAG6 complex is the need to efficiently remove regions of hydrophobic polypeptide from the cytosol in order to reduce their opportunity to initiate protein aggregation. For TA proteins...

...Axel Mogk; Tobias Haslberger; Peter Tessarz; Bernd Bukau A protein quality control system, consisting of molecular chaperones and proteases, controls the folding status of proteins and mediates the refolding or degradation of misfolded proteins. Ring-forming AAA+ (ATPase associated with various...