... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy neurodegeneration organelles protein quality control ubiquitin Valosin-containing protein (VCP, also p97, or Cdc48p in yeast...

... protein misfolding protein quality control ubiquitin ubiquitin proteasome system The proper functioning of proteins in cells is critical for all forms of life. Proteins serve as the molecular machines that facilitate a wide array of life-giving processes. The normal cellular function...

... correspondence should be addressed (email stephen.high@manchester.ac.uk ). 1 2 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cellular targeting proteasomes protein quality control ubiquitins Compartmentalization allows...

...Axel Mogk; Tobias Haslberger; Peter Tessarz; Bernd Bukau A protein quality control system, consisting of molecular chaperones and proteases, controls the folding status of proteins and mediates the refolding or degradation of misfolded proteins. Ring-forming AAA+ (ATPase associated with various...