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Keywords: protein quality control
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Biochem Soc Trans (2022) 50 (5): 1457–1469.
Published: 05 October 2022
... of substrates and novel pathways and substrates that utilize its activity. Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. VCP...
Biochem Soc Trans (2016) 44 (3): 796–801.
Published: 09 June 2016
... adding to the complexity of its role in protein quality control. Central to the activities of both SGTA and the BAG6 complex is the need to efficiently remove regions of hydrophobic polypeptide from the cytosol in order to reduce their opportunity to initiate protein aggregation. For TA proteins...