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Keywords: protein misfolding
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Articles
Biochem Soc Trans (2022) 50 (1): 321–334.
Published: 23 December 2021
... 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 extracellular chaperones extracellular proteostasis protein conformation protein misfolding One striking similarity between known ECs is that they are all multifunctional...
Articles
Biochem Soc Trans (2021) 49 (2): 977–985.
Published: 30 April 2021
...Marcus Fändrich; Matthias Schmidt Systemic amyloidosis is defined as a protein misfolding disease in which the amyloid is not necessarily deposited within the same organ that produces the fibril precursor protein. There are different types of systemic amyloidosis, depending on the protein...
Articles
Biochem Soc Trans (2021) 49 (1): 365–377.
Published: 26 February 2021
... the evidence for ubiquitination in this critical pathway, the precise complement of ubiquitin ligases and deubiquitinases that modulate this process remains under investigation. Whilst chaperones act as the first line of defence against protein misfolding, the ubiquitination machinery has a pivotal role...
Articles
Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
... lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological chaperones protein misfolding The central dogma of molecular biology dictates that information flows from DNA through RNA to proteins. That information, comprising the primary sequence, is sufficient...
Articles
Biochem Soc Trans (2012) 40 (4): 721–727.
Published: 20 July 2012
... Alzheimer's disease amyloid insulin/IGF-1-like signalling (IIS) protein misfolding tau AD and all of the age-related neurodegenerative disorders are fundamentally protein-folding disorders. In AD, excessive levels of a peptide, Aβ (amyloid β-peptide), and a protein, the MAPT (microtubule...
Articles
Biochem Soc Trans (2011) 39 (4): 1107–1111.
Published: 20 July 2011
... stress and these can be found in Figure 1 . Figure 1 Schematic overview of inflammation-associated triggers which can provoke protein misfolding ER-dependent protein folding in IECs of patients with active IBD is affected by several inflammatory triggers. As mentioned above, different...
Articles
Biochem Soc Trans (2010) 38 (2): 539–544.
Published: 22 March 2010
... of AD caused by protein misfolding; another example is the polymerization of the microtubule-associated protein tau into insoluble filaments that aggregate as NFTs (neurofibrillary tangles) [ 14 , 15 ]. AAR and AAI represent the major non-enzymatic age-dependent covalent modifications affecting...
Articles
Biochem Soc Trans (2007) 35 (6): 1551–1557.
Published: 23 November 2007
... (email ruhongz@us.ibm.com ) 29 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Molecular Dynamics protein lysozyme protein misfolding protein stability single mutation wavelet analysis The loss of protein stability and subsequent protein...
Articles
Biochem Soc Trans (2006) 34 (1): 43–44.
Published: 20 January 2006
... and behavioural levels. 1 To whom correspondence should be addressed (email V.M.O'Connor@soton.ac.uk ). 31 10 2005 © 2006 The Biochemical Society 2006 genetic disease model organism molecular determinant protein misfolding synapse synaptic function The Biochemical Society...
Articles
Biochem Soc Trans (2002) 30 (4): 569–573.
Published: 01 August 2002
... disease protein misfolding scrapie CJD, Creutzfeldt-Jakob disease TSE, transmissible spongiform encephalopathy PMCA, protein misfolding cyclic amplification Amyloidogenic Proteins Involved in Neurodegeneration and Therapeutic Implications 32 33 34 35 36 37 38 39 Gabizon, R., Meiner, Z...