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Keywords: protein misfolding
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Articles
Biochem Soc Trans (2022) 50 (1): 321–334.
Published: 23 December 2021
... of the Biochemical Society 2022 extracellular chaperones extracellular proteostasis protein conformation protein misfolding Proteostasis refers to a delicately tuned balance between the processes of protein synthesis, folding, localization, and degradation. Proteins act as sensors, transducers...
Articles
Biochem Soc Trans (2021) 49 (2): 977–985.
Published: 30 April 2021
...Marcus Fändrich; Matthias Schmidt Systemic amyloidosis is defined as a protein misfolding disease in which the amyloid is not necessarily deposited within the same organ that produces the fibril precursor protein. There are different types of systemic amyloidosis, depending on the protein...
Articles
Biochem Soc Trans (2021) 49 (1): 365–377.
Published: 26 February 2021
... the evidence for ubiquitination in this critical pathway, the precise complement of ubiquitin ligases and deubiquitinases that modulate this process remains under investigation. Whilst chaperones act as the first line of defence against protein misfolding, the ubiquitination machinery has a pivotal role...
Articles
Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
... lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological chaperones protein misfolding The central dogma of molecular biology dictates that information flows from DNA through RNA to proteins. That information, comprising the primary sequence, is sufficient...
Articles
Biochem Soc Trans (2012) 40 (4): 721–727.
Published: 20 July 2012
... cause increased levels and/or fibrillogenicity of Aβ peptides and plaque formation (for reviews, see [ 1 – 3 ]). © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease amyloid insulin/IGF-1-like signalling (IIS) protein misfolding tau Figure 1 A model...
Articles
Biochem Soc Trans (2011) 39 (4): 1107–1111.
Published: 20 July 2011
... ). 2 These authors contributed equally to this work. 28 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endoplasmic reticulum stress (ER stress) inflammatory bowel disease (IBD) intestinal epithelial cell protein misfolding unfolded protein...
Articles
Biochem Soc Trans (2010) 38 (2): 539–544.
Published: 22 March 2010
..., University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark 5 1 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 aging Alzheimer's disease amyloid β-peptide isomerization protein misfolding racemization The word ‘aging’ brings to mind...
Articles
Biochem Soc Trans (2007) 35 (6): 1551–1557.
Published: 23 November 2007
... conclusions of the experiment, but also provide a detailed but somewhat different molecular picture of the disruption of the long-range interactions. © The Authors Journal compilation © 2007 Biochemical Society 2007 Molecular Dynamics protein lysozyme protein misfolding protein stability single...
Articles
Biochem Soc Trans (2006) 34 (1): 43–44.
Published: 20 January 2006
... and behavioural levels. 1 To whom correspondence should be addressed (email V.M.O'Connor@soton.ac.uk ). 31 10 2005 © 2006 The Biochemical Society 2006 genetic disease model organism molecular determinant protein misfolding synapse synaptic function The Biochemical Society...
Articles
Biochem Soc Trans (2002) 30 (4): 569–573.
Published: 01 August 2002
... disease protein misfolding scrapie CJD, Creutzfeldt-Jakob disease TSE, transmissible spongiform encephalopathy PMCA, protein misfolding cyclic amplification Amyloidogenic Proteins Involved in Neurodegeneration and Therapeutic Implications 32 33 34 35 36 37 38 39 Gabizon, R., Meiner, Z...