...), the possibility that FcγR function in the clearance of SAP-misfolded protein complexes has yet to be investigated. extracellular chaperones extracellular proteostasis protein conformation protein misfolding Proteostasis refers to a delicately tuned balance between the processes of protein...

...Marcus Fändrich; Matthias Schmidt Systemic amyloidosis is defined as a protein misfolding disease in which the amyloid is not necessarily deposited within the same organ that produces the fibril precursor protein. There are different types of systemic amyloidosis, depending on the protein...

... the evidence for ubiquitination in this critical pathway, the precise complement of ubiquitin ligases and deubiquitinases that modulate this process remains under investigation. Whilst chaperones act as the first line of defence against protein misfolding, the ubiquitination machinery has a pivotal role...

... chaperones protein misfolding The central dogma of molecular biology dictates that information flows from DNA through RNA to proteins. That information, comprising the primary sequence, is sufficient to direct protein folding which can occur in microseconds for small proteins. Folding of large...

... inflammatory component through astrocytic and microglial responses, which is closely related to the aberrant protein folding and impaired clearance of Aβ and tau [ 13 ]. AD occurs randomly in the aging population and the underlying cause of protein misfolding, synaptic malfunction and associated...

... protein misfolding to neurodegeneration Nature 2006 441 513 517 20 Townsend D.M. Manevich Y. He L. Xiong Y. Bowers R.R. Jr Hutchens S. Tew K.D. Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase leads to activation of the unfolded...

..., such as soluble Aβ oligomers and protofibrils, which accumulate in the synapses, producing a dramatic impairment of synaptic plasticity [ 17 , 18 ]. The aggregation of Aβ is not the only neuropathological event of AD caused by protein misfolding; another example is the polymerization of the microtubule-associated...

... conclusions of the experiment, but also provide a detailed but somewhat different molecular picture of the disruption of the long-range interactions. Molecular Dynamics protein lysozyme protein misfolding protein stability single mutation wavelet analysis The loss of protein stability...

... direct mutations in synaptic molecules (e.g. glycine transporters or scaffold proteins) or more circumspect disruption of synaptic processes by protein misfolding diseases (e.g. Alzheimer's disease or prion disease), the value in increasing our understanding of the molecular determinants of synaptic...

... and diagnostic strategies for these devastating diseases are described. CJD, Creutzfeldt-Jakob disease TSE, transmissible spongiform encephalopathy PMCA, protein misfolding cyclic amplification bovine spongiform encephalopathy Creutzfeldt-Jakob disease protein misfolding scrapie © 2002...