... 17 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell polarity microtubule protein kinase C (PKC) signal transduction T-cell These two cytoskeletal remodelling events serve as the foundation for IS structure and the basis for its function...

...Corina E. Antal; Alexandra C. Newton Precise control of the amplitude of protein kinase C (PKC) signalling is essential for cellular homoeostasis, and disruption of this control leads to pathophysiological states such as cancer, neurodegeneration and diabetes. For conventional and novel PKC...

...Anuradha Tarafdar; Alison M. Michie The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms...

... of Nature's concept to cope with malfunctions. 1 To whom correspondence should be addressed (email margot.zoeller@uni-heidelberg.de ). 31 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 exosome multivesicular body (MVB) protein kinase C (PKC) target...

... that target mutated versions of kinases [ 33 , 34 ] or alternatively the development of inhibitors that lock inactive conformers of their target kinases such as the DFG-out inhibitors. allosteric regulation mammalian target of rapamycin (mTOR) nucleotide-binding pocket protein kinase C (PKC...

... (email t.biden@garvan.org.au ). 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 glucose-stimulated insulin secretion insulin secretion lipotoxicity pancreatic β-cell protein kinase C (PKC) Type 2 diabetes The PKC (protein kinase C) family...

... Journal compilation © 2008 Biochemical Society 2008 cadherin cell–cell adhesion desmosome hyper-adhesion protein kinase C (PKC) Body tissues are immensely tough. They have to be in order to resist the physical stresses and strains of everyday life. The epidermis averages only five cell...

...@cancer.org.uk ). 1 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 protein kinase B (PKB) protein kinase C (PKC) phosphoinositide-dependent kinase 1 (PDK1) phosphorylation pleckstrin homology domain (PH domain) protein serine/threonine kinase In mammals...

... acting as a tumour suppressor instead of being a promoter as suggested from PMA data. 1 email michael.leitges@biotek.uio.no . 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cancer deficient mouse model diacylglycerol (DAG) protein kinase C (PKC...

... inhibitor molecular modelling protein kinase C (PKC) protein kinase Cθ inhibitor structure-based optimization T-cell Collectively, as shown in Figure 3 , these efforts helped improve selectivity against PKCδ severalfold, confirming the hypothesis that improved selectivity for both series...

...@stanford.edu ). 3 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis cardiac ischaemia/reperfusion injury ischaemic preconditioning proteasome protein kinase C (PKC) reactive oxygen species Cellular viability is determined by the balance of pro...

... The Authors Journal compilation © 2007 Biochemical Society 2007 C2 domain calcium phosphatidylserine polybasic cluster protein kinase C (PKC) PtdIns(4,5) P 2 PKC (protein kinase C) is a large family of phospholipid-dependent serine/threonine kinases, which is activated by many extracellular...

... apoptosis caspase 3 genotoxin nuclear localization protein kinase C (PKC) tyrosine phosphorylation Apoptosis was originally described by Kerr et al. [ 1 ] as a pattern of morphological changes including membrane blebbing and nuclear condensation, which were distinct from cell death associated...

... 2007 Biochemical Society 2007 aldosterone epidermal growth factor receptor (EGFR) epithelial sodium channel (ENaC) hypertension protein kinase C (PKC) protein kinase D (PKD) The mineralocorticoid hormone, aldosterone, is released into the circulation by the adrenal cortex as the final...

... paper. © 2007 The Biochemical Society 2007 cell migration chemokine GTPase phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) T-lymphocyte Trafficking of T-lymphocytes in lymphoid and peripheral tissues during immunosurveillance and immune responses involves a multi-step...

... 2005 chromaffin cell exocytosis 25 kDa synaptosome-associated protein (SNAP-25) Munc18 phorbol ester protein kinase C (PKC) Studies in the last few years have begun to identify how phosphorylation of distinct proteins at defined sites contributes to the regulation of various stages...

... resistance. 1 To whom correspondence should be addressed (email tjnelson@brni-jhu.org ). 17 6 2005 © 2005 The Biochemical Society 2005 Alzheimer's disease (AD) β-amyloid cholesterol insulin memory protein kinase C (PKC) Both insulin and cholesterol have long been...

... fluorescent protein nucleus phospholipase C protein kinase C (PKC) sperm Abbreviations used: IP 3 , inositol 1,4,5-trisphosphate; PLC, phospholipase C; IP 3 R, IP 3 receptor; PKC, protein kinase C; PIP 2 , phosphatidylinositol 4,5-bisphosphate; PH, pleckstrin homology; GFP, green fluorescent...