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Keywords: protein kinase B
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Biochem Soc Trans (2021) 49 (1): 41–54.
Published: 05 February 2021
...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. amino acids computational models mechanistic target of rapamycin protein kinase B signaling systems biology Kinase signaling networks are a prime example of highly dynamic biological systems whose...
Biochem Soc Trans (2018) 46 (1): 37–42.
Published: 01 December 2017
... abnormalities have been discovered in hearts of mouse models of cardiomyopathy caused by LMNA mutations that contribute to pathogenesis. These include abnormally increased signaling by extracellular signal-regulated kinase 1 and kinase 2 and other mitogen-activated protein kinases, protein kinase B/mammalian...
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... cell migration endosomal sorting protein kinase B Rab5 trafficking Signaling endosomes are believed to function as platforms for integrating distinct communication pathways within cells [ 1 ]. Endosome-associated adaptor proteins are critical in mediating this cross-talk between signaling...
Biochem Soc Trans (2016) 44 (6): 1675–1682.
Published: 02 December 2016
...) signaling. © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 PHLPP1 PHLPP2 phosphatase PP2C protein kinase B tumor suppressor PHLPP is evolutionarily conserved from yeast to humans [ 7 ]. Intriguingly, the yeast homolog of PHLPP...
Biochem Soc Trans (2005) 33 (2): 346–349.
Published: 01 April 2005
...G.I. Welsh; I. Hers; D.C. Berwick; G. Dell; M. Wherlock; R. Birkin; S. Leney; J.M. Tavaré The activation of protein kinase B (or Akt) plays a central role in the stimulation of glucose uptake by insulin. Currently, however, numerous questions remain unanswered regarding the role of this kinase...
Biochem Soc Trans (2004) 32 (5): 837–839.
Published: 26 October 2004
...S. Elhyany; E. Assa-Kunik; S. Tsory; T. Muller; S. Fedida; S. Segal; D. Fishman A deregulated activity of PKB/Akt (where PKB stands for protein kinase B) renders tumour cells resistant to a variety of apoptosis-inducing stimuli. Elucidation of the mechanisms responsible for this deregulation...
Biochem Soc Trans (2004) 32 (2): 350–354.
Published: 01 April 2004
... few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals. 17...
Biochem Soc Trans (2003) 31 (3): 573–578.
Published: 01 June 2003
... of research in this area has come from the discovery of the tuberous sclerosis complex gene products, tuberin and hamartin, as central regulators of mTOR activation. The PI3K effector Akt/protein kinase B has been found to directly phosphorylate tuberin and is thereby thought to activate mTOR through...
Biochem Soc Trans (2003) 31 (1): 292–297.
Published: 01 February 2003
... in rhabdomyosarcoma) and FKHR-L1 (FKHR-like 1) transcription factors are directly phosphorylated by protein kinase B, resulting in nuclear export and inhibition of transcription. This signalling pathway was first identified in the nematode worm Caenorhabditis elegans , where it has a role in regulation of the life...