... To whom correspondence should be addressed (email khalid.naseem@hyms.ac.uk ). 19 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA...

... cyclic-nucleotide-modulated channel (HCN) protein kinase A (PKA) selectivity signalling cAMP is a universal second messenger that relays and amplifies extracellular signals by causing conformational changes in intracellular CBDs (cAMP-binding domains) [ 1 , 2 ]. In eukaryotes, CBDs regulate...

... (MLCP) platelet protein kinase A (PKA) RhoA Rho-associated kinase (ROCK) Circulating blood platelets scan the integrity of the vascular endothelium for damage and adhere to areas of injury where the extracellular matrix proteins collagen and vWF (von Willebrand factor) have become exposed...

... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling The IMS is the second aqueous compartment of mitochondria (the other being the matrix). The IMS is defined by the OMM and IMM and has emerged as a significant regulatory domain in the co-ordination...

... endothelial barrier function exchange protein directly activated by cAMP (Epac) guanine-nucleotide-exchange factor (GEF) protein kinase A (PKA) vascular smooth muscle vasculature vasodilatation The second messenger cAMP controls a range of vascular processes, including endothelial barrier...

... [ 35 – 37 ]. 1 To whom correspondence should be addressed (email staylor@ucsd.edu ). ATP GTP protein kinase protein kinase A (PKA) pseudokinase Raf Protein kinases represent one of the largest gene families in eukaryotic organisms [ 1 ]. They have evolved to be dynamic...

... (email jeroen.claus@cancer.org.uk ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer epidermal growth factor receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase The collection of all kinases in a cell, the kinome...

... represents an exciting new therapeutic avenue for the prevention and treatment of myocardial remodelling and ischaemic injury. cardioprotection heat-shock protein 20 (Hsp20) phosphodiesterase type 4 (PDE4) phosphorylation protein kinase A (PKA) small heat-shock protein Hsps (heat-shock...

... in brain and heart, and discuss the potential implication of Epac in CNS (central nervous system) and cardiac disorders. cAMP exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor guanine-nucleotide-exchange factor heart failure protein kinase A (PKA) Cardiac...

..., as it depends on the presence of MAF1. 1 email Annemieke.Michels@unil.ch 8 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 MAF1 mammalian target of rapamycin complex 1 (mTORC1) protein kinase A (PKA) RNA polymerase III S6 kinase 1 (S6K1) Sch9...

...-arrestin cAMP phosphodiesterase cardiomyocyte phosphodiesterase-4D5 (PDE4D5) protein kinase A (PKA) cAMP is a critical second messenger that can influence and regulate a vast array of cellular events vital for the response and control of signalling pathways to environmental cues [ 1 – 3...

... compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) Figure 2 AKAP450 targets PKA Type II and PDE4D3 to the centrosomal region in Sertoli cells A similar mechanism operates in cardiomyocytes, where mAKAP binds and targets both PDE4D3 and PKA Type...

... myocytes [ 35 ]. action potential depolarization phosphorylation protein kinase A (PKA) sodium channel tyrosine kinase Neuronal signals are comprised of action potentials passing along the length of axons and passing from one neuron to the next at synapses. Sodium channels underlie...

... cAMP cardiomyocyte phosphodiesterase (PDE) protein kinase A (PKA) The force and frequency of cardiomyocyte contraction is continuously tuned by a number of signals conveyed from the bloodstream, the neighbouring cells and the cardiac nerve endings. Many such signals exert their function...

... kinase A (PKA) scaffolding protein AKAP A-kinase-anchoring protein AKAP IS AKAP in silico AKB A-kinase-binding AQP2 aquaporin-2 PGE 1 prostaglandin E 1 PKA protein kinase A This work was supported by grants from Deutsche Forschungsgemeinschaft...

... To whom correspondence should be addressed (email anders.tengholm@mcb.uu.se ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Since cAMP is involved in many...

...) protein kinase A (PKA) sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase 2 (SERCA2) Contraction and relaxation of heart muscle cells are regulated by calcium (Ca 2+ ) cycling between the cytoplasm (sarcoplasm) and SR (sarcoplasmic reticulum) ( Figure 1 ). Myocyte mishandling of Ca 2+ is a central...

... 2006 The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) cAMP cycling compartmentalization protein kinase A (PKA) Although the investigation of cAMP signalling has been underway for over 50 years, it was not until the early 1980s that the compartmentalized modulation...

... Lck phosphodiesterase protein kinase A (PKA) T-cell Csk regulates Lck activity by phosphorylation of a C-terminal inhibitory tyrosine residue (Lck-Tyr 505 ). So far, two different mechanisms are reported to regulate Csk activity [ 4 , 5 ]. PKA type I, through phosphorylation of Ser 364...

... disease cAMP exchange protein directly activated by cAMP (EPAC) guanine nucleotide-exchange factor (GEF) protein kinase A (PKA) Rap Although the effects of cAMP-mediated signalling are wide ranging, there are only two general cAMP effectors, i.e. proteins that are activated by binding to cAMP...

... of future therapeutics for diseases where cAMP signalling through Rap1 is improperly regulated. cAMP exchange protein directly activated by cAMP (EPAC) light chain 2 microtubule-associated protein (MAP) protein kinase A (PKA) Rap1 1 email S.Yarwood@bio.gla.ac.uk 13 6 2005...

... © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity AMPA α-amino-3-hydroxy...

... 26665 1 To whom correspondence should be addressed (email klussmann@fmp-berlin.de ). 21 6 2005 © 2005 The Biochemical Society 2005 A-kinase anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP compartmentalization exocytosis protein kinase A (PKA) Various hormones...

... fbp1 transcription G-protein Schizosaccharomyces pombe protein kinase A (PKA) Nutrient sensing is critical to the survival of both prokaryotic and eukaryotic micro-organisms, which adjust their metabolism to utilize the resources available in their growth environment or enact...

... at Chancellors Conference Centre, University of Manchester, 1–3 December 2003 19 November 2003 © 2004 Biochemical Society 2004 integrin mitogen-activated protein kinase (MAP kinase) motility p21-activated kinase (PAK) protein kinase A (PKA) Rho GTPase Abbreviations used: ECM...