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Keywords: protein kinase A (PKA)
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Articles
Biochem Soc Trans (2014) 42 (2): 289–294.
Published: 20 March 2014
... A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA) The activation of blood platelets at sites of vascular injury is critical to haemostasis and prevention of blood loss, but, if unregulated, can lead to pathological thrombosis...
Articles
Biochem Soc Trans (2014) 42 (2): 279–283.
Published: 20 March 2014
... light chain phosphatase (MLCP) platelet protein kinase A (PKA) RhoA Rho-associated kinase (ROCK) Circulating blood platelets scan the integrity of the vascular endothelium for damage and adhere to areas of injury where the extracellular matrix proteins collagen and vWF (von Willebrand factor...
Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling In its simplest form, i.e. generation of messenger in response to extracellular stimuli followed by activation of its effectors and termination by PDEs, the cAMP signalling cascade is not sufficient...
Articles
Biochem Soc Trans (2014) 42 (2): 302–307.
Published: 20 March 2014
... in vivo , they may inactivate the protein by shifting the relative populations towards the inactive state, irrespective of whether it is apo or holo. cAMP exchange protein directly activated by cAMP (Epac) hyperpolarization-activated cyclic-nucleotide-modulated channel (HCN) protein kinase A (PKA...
Articles
Biochem Soc Trans (2014) 42 (1): 89–97.
Published: 23 January 2014
... (email c.dart@liv.ac.uk ). 5 11 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cAMP endothelial barrier function exchange protein directly activated by cAMP (Epac) guanine-nucleotide-exchange factor (GEF) protein kinase A (PKA) vascular smooth muscle...
Articles
Biochem Soc Trans (2013) 41 (4): 981–986.
Published: 18 July 2013
... that are independent of catalysis. 1 To whom correspondence should be addressed (email staylor@ucsd.edu ). 20 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 ATP GTP protein kinase protein kinase A (PKA) pseudokinase Raf Protein kinases represent one...
Articles
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
... receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase The eukaryotic cell is a staggeringly complex environment, with intricate regulatory mechanisms underpinning every aspect of its behaviour. At the heart of many of these regulatory mechanisms is the requirement...
Articles
Biochem Soc Trans (2012) 40 (1): 210–214.
Published: 19 January 2012
... 2012 cardioprotection heat-shock protein 20 (Hsp20) phosphodiesterase type 4 (PDE4) phosphorylation protein kinase A (PKA) small heat-shock protein Hsps (heat-shock proteins) are a diverse group of molecular chaperones that are up-regulated in response to cellular stress. Originally...
Articles
Biochem Soc Trans (2012) 40 (1): 51–57.
Published: 19 January 2012
... is responsible for the exchange of GDP with GTP on Rap GTPases. cAMP exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor guanine-nucleotide-exchange factor heart failure protein kinase A (PKA) Figure 2 Biological, pathological roles and effectors of Epacs...
Articles
Biochem Soc Trans (2011) 39 (2): 487–491.
Published: 22 March 2011
... and Ser 75 [ 27 ]. These results identified human MAF1 as a new substrate of mTORC1. © The Authors Journal compilation © 2011 Biochemical Society 2011 MAF1 mammalian target of rapamycin complex 1 (mTORC1) protein kinase A (PKA) RNA polymerase III S6 kinase 1 (S6K1) Sch9...
Articles
Biochem Soc Trans (2007) 35 (5): 931–937.
Published: 25 October 2007
... in the orchestration of intracellular signalling events in health and disease (for references and recent reviews see [ 3 , 6 , 8 , 9 , 16 ]). A-kinase-anchoring protein (AKAP) cAMP compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) (D...
Articles
Biochem Soc Trans (2007) 35 (5): 938–941.
Published: 25 October 2007
...-arrestin cAMP phosphodiesterase cardiomyocyte phosphodiesterase-4D5 (PDE4D5) protein kinase A (PKA) cAMP is a critical second messenger that can influence and regulate a vast array of cellular events vital for the response and control of signalling pathways to environmental cues [ 1 – 3...
Articles
Biochem Soc Trans (2006) 34 (6): 1299–1302.
Published: 25 October 2006
.... Identified phosphorylation sites for protein kinase A are depicted as red circles and for protein kinase C as red diamonds. action potential depolarization phosphorylation protein kinase A (PKA) sodium channel tyrosine kinase Neuronal signals are comprised of action potentials passing...
Articles
Biochem Soc Trans (2006) 34 (4): 510–511.
Published: 21 July 2006
... cAMP cardiomyocyte phosphodiesterase (PDE) protein kinase A (PKA) The force and frequency of cardiomyocyte contraction is continuously tuned by a number of signals conveyed from the bloodstream, the neighbouring cells and the cardiac nerve endings. Many such signals exert their function...
Articles
Biochem Soc Trans (2006) 34 (4): 465–467.
Published: 21 July 2006
... compartmentalization protein kinase A (PKA) Perhaps the most prominent biological role for AKAPs was discovered when it was shown that AKAP79 (the human orthologue of bovine AKAP75 and murine AKAP150) not only anchored PKA but also bound calcineurin, a calmodulin-dependent phosphatase {also called PP2B...
Articles
Biochem Soc Trans (2006) 34 (4): 476–479.
Published: 21 July 2006
... to abrogate the negative feedback by cAMP which is elicited in the absence of a co-receptor stimulus. cAMP C-terminal Src kinase (Csk) immunomodulation Lck phosphodiesterase protein kinase A (PKA) T-cell TCR (T-cell receptor) is a multimeric complex consisting of two functional units, one...
Articles
Biochem Soc Trans (2006) 34 (4): 472–473.
Published: 21 July 2006
... kinase A (PKA) scaffolding protein A variety of hormones, neurotransmitters and other stimuli mediate activation of the G s /adenylate cyclase system and thereby induce the generation of the second messenger cAMP and activation of PKA (protein kinase A), a serine/threonine kinase. The inactive PKA...
Articles
Biochem Soc Trans (2006) 34 (4): 498–501.
Published: 21 July 2006
... To whom correspondence should be addressed (email anders.tengholm@mcb.uu.se ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Nuclear translocation of the PKA...
Articles
Biochem Soc Trans (2006) 34 (4): 489–491.
Published: 21 July 2006
... in the cardiomyocyte, the possibility exists that even more AKAPs are located in the SR region and involved in targeting PKA to its substrates. A-kinase-anchoring protein (AKAP) cAMP excitation–contraction coupling heart phospholamban (PLB) protein kinase A (PKA) sarcoplasmic/endoplasmic-reticulum Ca 2...
Articles
Biochem Soc Trans (2005) 33 (6): 1327–1329.
Published: 26 October 2005
... S.Yarwood@bio.gla.ac.uk 13 6 2005 © 2005 The Biochemical Society 2005 cAMP exchange protein directly activated by cAMP (EPAC) light chain 2 microtubule-associated protein (MAP) protein kinase A (PKA) Rap1 Many extracellular physiological signalling agents increase...
Articles
Biochem Soc Trans (2005) 33 (6): 1330–1332.
Published: 26 October 2005
... disease cAMP exchange protein directly activated by cAMP (EPAC) guanine nucleotide-exchange factor (GEF) protein kinase A (PKA) Rap Although the effects of cAMP-mediated signalling are wide ranging, there are only two general cAMP effectors, i.e. proteins that are activated by binding to cAMP...
Articles
Biochem Soc Trans (2005) 33 (6): 1354–1356.
Published: 26 October 2005
... © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity AMPA α-amino-3-hydroxy...
Articles
Biochem Soc Trans (2005) 33 (6): 1316–1318.
Published: 26 October 2005
... 26665 1 To whom correspondence should be addressed (email klussmann@fmp-berlin.de ). 21 6 2005 © 2005 The Biochemical Society 2005 A-kinase anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP compartmentalization exocytosis protein kinase A (PKA) Various hormones...
Articles
Biochem Soc Trans (2005) 33 (1): 257–260.
Published: 01 February 2005
... and Nestlé U.K. Ltd. git glucose insensitive transcription PKA protein kinase A PDE phosphodiesterase adenylate cyclase cAMP fbp1 transcription G-protein Schizosaccharomyces pombe protein kinase A (PKA) Nutrient sensing is critical to the survival of both...
Articles
Biochem Soc Trans (2004) 32 (3): 443–446.
Published: 01 June 2004
... at Chancellors Conference Centre, University of Manchester, 1–3 December 2003 19 November 2003 © 2004 Biochemical Society 2004 integrin mitogen-activated protein kinase (MAP kinase) motility p21-activated kinase (PAK) protein kinase A (PKA) Rho GTPase Abbreviations used: ECM...