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Keywords: protein kinase
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Articles
Biochem Soc Trans (2014) 42 (1): 145–150.
Published: 23 January 2014
...Kristina Lorenzen; Tony Pawson In recent years, HDX-MS (hydrogen–deuterium exchange coupled to MS) on biomolecules has evolved from a niche technique to a powerful method in the investigation of protein dynamics. Protein kinases, in particular, represent an area of active study using this technique...
Articles
Biochem Soc Trans (2014) 42 (1): 35–41.
Published: 23 January 2014
...Mark Linch; Philippe Riou; Jeroen Claus; Angus J. Cameron; Julien de Naurois; Banafshe Larijani; Tony Ng; Neil Q. McDonald; Peter J. Parker The empirical derivation of PKC (protein kinase C) domain structures and those modelled by homology or imputed from protein behaviour have been extraordinarily...
Articles
Biochem Soc Trans (2013) 41 (4): 981–986.
Published: 18 July 2013
...Susan S. Taylor; Andrey Shaw; Jiancheng Hu; Hiruy S. Meharena; Alexandr Kornev The catalytic (C) subunit of PKA was the first protein kinase structure to be solved, and it continues to serve as the prototype for the protein kinase superfamily. In contrast, by comparing many active and inactive...
Articles
Biochem Soc Trans (2013) 41 (4): 1037–1041.
Published: 18 July 2013
... architecture. Most mitotic protein phosphorylation events are catalysed by a small subset of serine/threonine protein kinases. These include members of the Cdk (cyclin-dependent kinase), Plk (Polo-like kinase), Aurora, Nek (NimA-related kinase) and Bub families, as well as Haspin, Greatwall and Mps1/TTK...
Articles
Biochem Soc Trans (2011) 39 (2): 443–445.
Published: 22 March 2011
... that PR61ϵ, a B56 family regulatory subunit of PP2A (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase regulated by amino acid sufficiency that acts upstream of mTORC1. In searching for a physiological...
Articles
Biochem Soc Trans (2011) 39 (2): 431–436.
Published: 22 March 2011
...Christopher G. Proud The TOR (target of rapamycin) proteins are found in all eukaryotes. TOR has a protein kinase domain, as well as other domains through which it interacts with partner proteins to form at least two types of multiprotein complex, TORC1 and TORC2 (TOR complexes 1 and 2). Rapamycin...
Articles
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
... composition, protein kinases and neuronal activity during development and in response to sensory experience. Recent evidence indicates that Ca 2+ permeability of neuronal NMDARs, NMDAR-mediated Ca 2+ signalling in spines and induction of NMDAR-dependent LTP (long-term potentiation) at hippocampal Schaffer...
Articles
Biochem Soc Trans (2009) 37 (4): 627–641.
Published: 22 July 2009
...Louise N. Johnson Phosphorylation plays essential roles in nearly every aspect of cell life. Protein kinases regulate signalling pathways and cellular processes that mediate metabolism, transcription, cell-cycle progression, differentiation, cytoskeleton arrangement and cell movement, apoptosis...
Articles
Biochem Soc Trans (2009) 37 (1): 227–231.
Published: 20 January 2009
... factors and hypertrophic stimuli. mTORC1 signalling regulates several components of the protein synthetic machinery, including initiation and elongation factors, protein kinases which phosphorylate the ribosome and/or translation factors, and the translation of specific mRNAs. However, there are still...
Articles
Biochem Soc Trans (2009) 37 (1): 213–216.
Published: 20 January 2009
...Deborah C.I. Goberdhan; C.A. Richard Boyd mTOR (mammalian target of rapamycin) is a highly conserved serine/threonine protein kinase that has roles in cell metabolism, cell growth and cell survival. Although it has been known for some years that mTOR acts as a hub for inputs from growth factors...
Articles
Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... 76 serine, 36 threonine and 13 tyrosine residues, many of which score as consensus phosphorylation sites for various protein kinases [ 17 ]. Initial approaches, using mutagenesis of consensus PKA (protein kinase A), PKC (protein kinase C) and CaMKII (Ca 2+ /calmodulin-dependent protein kinase II...
Articles
Biochem Soc Trans (2007) 35 (1): 7–11.
Published: 22 January 2007
...L. Johnson This review focuses on the recognition properties of protein kinases at the molecular level. Phosphorylation of the substrate protein by a protein kinase can result in enzyme activation or inhibition, conformational changes that change recognition properties, or the creation of a surface...
Articles
Biochem Soc Trans (2006) 34 (1): 7–11.
Published: 20 January 2006
...R.C. Wek; H.-Y. Jiang; T.G. Anthony In response to environmental stresses, a family of protein kinases phosphorylate eIF2 (eukaryotic initiation factor 2) to alleviate cellular injury or alternatively induce apoptosis. Phosphorylation of eIF2 reduces global translation, allowing cells to conserve...
Articles
Biochem Soc Trans (2005) 33 (5): 1170–1173.
Published: 26 October 2005
... molecules or second messengers under heat stress and during non-stressed conditions. LCBs are now recognized as regulators of AGC-type protein kinase (where AGC stands for protein kinases A, G and C) Pkh1 and Pkh2, which are homologues of mammalian phosphoinositide-dependent protein kinase 1. LCBs were...
Articles
Biochem Soc Trans (2004) 32 (5): 803–808.
Published: 26 October 2004
... of relatively selective small molecules have facilitated chemical manipulation of the enzyme in intact cells and tissues, and new roles for the protein kinase in embryonic stem cell differentiation and motility have emerged. Despite these advances, the therapeutic value of this enzyme as a drug target remains...
Articles
Biochem Soc Trans (2004) 32 (2): 330–331.
Published: 01 April 2004
..., relatively little is known about the function of the protein kinase activity. We discuss the evidence that suggests that the protein kinase activity of phosphoinositide 3-kinases mediates important signalling functions in cells. 1 To whom correspondence should be addressed (e-mail lafouk...
Articles
Biochem Soc Trans (2003) 31 (3): 728–730.
Published: 01 June 2003
... © 2003 Biochemical Society 2003 circadian rhythm crassulacean acid metabolism gene expression phosphoenolpyruvate carboxylase protein kinase Abbreviations used: CAM, crassulacean acid metabolism; PEPc, phosphoenolpyruvate carboxylase. 728 Biochemical Society Transactions...
Articles
Biochem Soc Trans (2001) 29 (2): 1–14.
Published: 01 May 2001
... in the future. Akt PKB PI 3-kinase PKC protein kinase AGC kinase AMPK, AMP-activated protein kinase ARF, ADP-ribosylation factor eIF2B, eukaryotic initiation factor 2B ERK, extracellular-signal-regulated kinase ES cells, embryonic stem cells GSK3, glycogen synthase kinase 3 IGF, insulin-like...