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Keywords: protein dynamics
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Articles
Biochem Soc Trans (2021) 49 (1): 131–144.
Published: 24 December 2020
... of the Biochemical Society 2020 enzyme structure enzyme-substrate interactions isotope labelling magic angle spinning molecular docking protein dynamics Enzyme catalysis is required for the vast majority of biochemical reactions to attain rates compatible with the time scales of living organisms...
Articles
Biochem Soc Trans (2019) 47 (4): 1101–1116.
Published: 08 August 2019
... of the Biochemical Society 2019 molecular conformations protein dynamics protein-tyrosine kinases regulatory mechanisms At the end of the 1800s, photographers had been producing still images for nearly a century. The advent of moving pictures at this time caused a dramatic shift in the viewer's...
Articles
Biochem Soc Trans (2018) 46 (3): 587–597.
Published: 20 April 2018
... on behalf of the Biochemical Society 2018 allosteric regulation fractals protein conformation protein dynamics Figure 4. Entropy/dynamics-driven allostery model. Communities of residues that move coherently as semi-rigid bodies are coded with different colors. Intermediate residues...
Articles
Biochem Soc Trans (2016) 44 (3): 905–915.
Published: 09 June 2016
... of the Biochemical Society 2016 ABC proteins EPR spectroscopy membrane transport protein dynamics spin labelling Membrane transporter proteins comprise a wide variety of proteins which underpin a diverse range of functions–from the import of vital solutes to the efflux of a multitude of drugs...
Articles
Biochem Soc Trans (2015) 43 (5): 1023–1032.
Published: 09 October 2015
... by Portland Press Limited 2015 EPR MD simulations ABCB1 MsbA DEER PELDOR modelling protein dynamics Knowledge of the molecular structure of membrane proteins is essential to understand their function. Most direct structural information is derived from X-ray crystallography as well...
Articles
Biochem Soc Trans (2015) 43 (5): 773–786.
Published: 09 October 2015
...-translational modifications. A powerful tool to study the regulation of membrane signalling enzymes and complexes is hydrogen deuterium exchange–MS (HDX–MS), a technique that allows for the interrogation of protein dynamics upon membrane binding and recruitment. This review will highlight the theory...
Articles
Biochem Soc Trans (2014) 42 (1): 145–150.
Published: 23 January 2014
...Kristina Lorenzen; Tony Pawson In recent years, HDX-MS (hydrogen–deuterium exchange coupled to MS) on biomolecules has evolved from a niche technique to a powerful method in the investigation of protein dynamics. Protein kinases, in particular, represent an area of active study using this technique...
Articles
Biochem Soc Trans (2014) 42 (1): 139–144.
Published: 23 January 2014
...-relieving mutations. 1 To whom correspondence should be addressed (email melacin@mcmaster.ca ). 13 11 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 allostery cAMP cGMP covariance NMR protein dynamics singular value decomposition (SVD...
Articles
Biochem Soc Trans (2012) 40 (5): 955–962.
Published: 19 September 2012
... Society 2012 intrinsically disordered protein integrative method nuclear magnetic resonance (NMR) protein dynamics small-angle X-ray scattering (SAXS) IDPs (intrinsically disordered proteins) are nowadays recognized as fundamental elements to explain the complexity of living beings [ 1...
Articles
Biochem Soc Trans (2012) 40 (3): 531–538.
Published: 22 May 2012
... applications, these investigations provide fundamental insights into protein dynamics. FPs are structurally relatively simple, folding to an 11-stranded β-barrel encompassing a three-residue-based endogenous p -HBI [4-( p -hydroxybenzylidene)-5-imidazolinone] chromophore that only requires oxygen...
Articles
Biochem Soc Trans (2012) 40 (3): 515–521.
Published: 22 May 2012
...David R. Glowacki; Jeremy N. Harvey; Adrian J. Mulholland One of the most controversial questions in enzymology today is whether protein dynamics are significant in enzyme catalysis. A particular issue in these debates is the unusual temperature-dependence of some kinetic isotope effects for enzyme...
Articles
Biochem Soc Trans (2012) 40 (2): 409–414.
Published: 21 March 2012
... of the exchanger by other means such as altered protein dynamics or changes in domain orientation. The NMR studies also showed that binding of Ca 2+ reduces the flexibility of the Ca 2+ -binding loops. For NCX1-CBD2-AD, the conformational changes upon Ca 2+ binding are less pronounced than for CBD1, probably...
Articles
Biochem Soc Trans (2012) 40 (1): 219–223.
Published: 19 January 2012
... compilation © 2012 Biochemical Society 2012 allostery cAMP cGMP chemical shift covariance analysis (CHESCA) exchange protein directly activated by cAMP (Epac) nuclear magnetic resonance (NMR) protein dynamics cAMP is an ancient second messenger that controls a multitude of essential...
Articles
Biochem Soc Trans (2009) 37 (2): 349–353.
Published: 20 March 2009
... and substrate in a reactive configuration from which hydride is transferred by quantum mechanical tunnelling. In the present paper, we review results from experiments that probe the influence of protein dynamics on the chemical step of the reaction catalysed by TmDHFR (DHFR from Thermotoga maritima...
Articles
Biochem Soc Trans (2009) 37 (2): 354–357.
Published: 20 March 2009
... for studying the role of protein dynamics in enzyme catalysis [ 15 , 16 ], which is currently a hotly debated subject in the field. Although there is currently no crystal structure available for POR, the structures of several members of the SDR family have been used to derive a homology model of POR from...
Articles
Biochem Soc Trans (2008) 36 (1): 16–21.
Published: 22 January 2008
... that we have spearheaded from our work on quantum mechanical tunnelling effects linked to protein dynamics for H-transfer reactions, we review our recent progress in mapping macroscopic kinetic descriptors to an atomistic understanding of dynamics linked to biological H-tunnelling reactions. 22 6...
Articles
Biochem Soc Trans (2006) 34 (5): 979–982.
Published: 25 October 2006
... pair is used to explore protein dynamics on the same time scale as blinking, then careful control experiments are required to establish the behaviour of the protein rather than that of the probe [ 7 , 17 ]. On the other hand, if the protein dynamics are much faster or much slower than blinking...
Articles
Biochem Soc Trans (2005) 33 (4): 845–850.
Published: 01 August 2005
... decreased the protein mobility, such as freezing, dehydration, application of cross-linking agents, embedment in trehalose amorphous matrices etc. could suppress the ET (electron transfer) between Q A and Q B (see [ 3 , 15 , 16 ] and references cited therein). This review is focused on protein dynamics...