...Paul Curnow The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design...

... evolutionary biology protein design protein engineering remote mutation Enzymes have been used as biocatalysts for thousands of years, but our ability to understand how proteins function, and to utilise this knowledge to engineer and design new proteins for our own applications is a relatively...

.... Zaccai N.R. Armstrong C.T. Bromley E.H.C. Booth P.J. Brady L. A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology ACS Synth. Biol. 2012 1 240 250 10.1021/sb300028q 23651206 5 Woolfson D.N. Policy matters...

...Pamela J.E. Rowling; Elin M. Sivertsson; Albert Perez-Riba; Ewan R.G. Main; Laura S. Itzhaki Studying protein folding and protein design in globular proteins presents significant challenges because of the two related features, topological complexity and co-operativity. In contrast, tandem-repeat...

...; published by Portland Press Limited 2015 αRep combinatorial library crystal structure protein design repeat protein A long-term goal of protein engineering research is to create new artificial proteins able to interact specifically with predefined biological molecular ‘targets...

... tijana.grove@vt.edu ) 22 4 2015 © 2015 Authors; published by Portland Press Limited 2015 alternative protein scaffold biosensor imaging agent molecular recognition protein design repeat proteins The sensitivity and specificity of biosensors and imaging agents are decidedly...

...; published by Portland Press Limited 2015 biomolecular templating hybrid materials protein design repeat proteins tetratricopeptide repeat nanostructures Nowadays, the industrial sector demands complicated and sophisticated materials. These innovative materials with tailored properties...

... arrows whereas bait protein is indicated by closed arrows. affinity reagent antibody protein design protein–protein interactions protein purification repeat protein The design and engineering of repeat proteins has been particularly successful [ 1 – 10 ]. The natural function...

... should be addressed (email jshifman@mail.huji.ac.il ). 26 6 2013 © 2013 The Authors 2013 binding affinity binding landscape protein design protein–protein interaction saturated mutagenesis PPIs (protein–protein interactions) play a crucial role in virtually all...

... decade, protein engineering still faces numerous challenges. Often, designs do not work as anticipated and they still require substantial redesign. The present review focuses on the successes, the challenges and the limitations of rational protein design today. 1 These authors contributed...

... into a diverse range of protein–protein interaction scaffolds and have functions as varied as biological diffraction gratings and mechanical nanosprings [ 3 – 8 ]. β-roll motif engineering biomaterial protein design repeat protein tetratricopeptide repeat Aha azido-homoalanine ANK ankyrin...

... oxidoreductase protein design protein engineering synthetic protein All too commonly, it is inferred that a specific biochemical function is necessarily linked with either a singular enzyme structure or a particular primary sequence. This ignores the apparent ‘memory-less’ random Markovian process...

... leucine-zipper nanostructured material peptide α-helix protein design self-assembling peptide The concentre of designing coiled coils has been largely confined to self-assembling systems as these underlie functional nanostructured materials [ 1 ]. However, the technological scope of de novo...