...Paul Curnow The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design...

... evolutionary biology protein design protein engineering remote mutation Enzymes have been used as biocatalysts for thousands of years, but our ability to understand how proteins function, and to utilise this knowledge to engineer and design new proteins for our own applications is a relatively...

... Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . biotechnology molecular modelling protein design protein engineering synthetic biology BrisSynBio is supported by £13.6 million from Biotechnology and Biological Sciences Research Council (BBSRC...

...@vt.edu ) 22 4 2015 © 2015 Authors; published by Portland Press Limited 2015 alternative protein scaffold biosensor imaging agent molecular recognition protein design repeat proteins The sensitivity and specificity of biosensors and imaging agents are decidedly dependent...

... aitziber.lopezcortajarena@imdea.org ) . 20 4 2015 © 2015 Authors; published by Portland Press Limited 2015 biomolecular templating hybrid materials protein design repeat proteins tetratricopeptide repeat nanostructures Nowadays, the industrial sector demands complicated and sophisticated...

... with important practical applications. 1 To whom correspondence should be addressed (email lynne.regan@yale.edu ) . 30 4 2015 © 2015 Authors; published by Portland Press Limited 2015 affinity reagent antibody protein design protein–protein interactions protein purification repeat...

.... 1 These authors contributed equally to this review. 2 To whom correspondence should be addressed (email philippe.minard@u-psud.fr ) . 15 4 2015 © 2015 Authors; published by Portland Press Limited 2015 αRep combinatorial library crystal structure protein design repeat...

...Pamela J.E. Rowling; Elin M. Sivertsson; Albert Perez-Riba; Ewan R.G. Main; Laura S. Itzhaki Studying protein folding and protein design in globular proteins presents significant challenges because of the two related features, topological complexity and co-operativity. In contrast, tandem-repeat...

... should be addressed (email jshifman@mail.huji.ac.il ). 26 6 2013 © 2013 The Authors 2013 binding affinity binding landscape protein design protein–protein interaction saturated mutagenesis PPIs (protein–protein interactions) play a crucial role in virtually all...

... decade, protein engineering still faces numerous challenges. Often, designs do not work as anticipated and they still require substantial redesign. The present review focuses on the successes, the challenges and the limitations of rational protein design today. 1 These authors contributed...

... Engineering, Granta Park, Cambridge CB21 6GH, U.K. 11 6 2013 © 2013 The Authors 2013 β-roll motif engineering biomaterial protein design repeat protein tetratricopeptide repeat Repeat or solenoid proteins are incredibly ubiquitous protein folds that typically form non-globular...

.... Unfortunately, leaps from this level of detail out to broader discussions of evolved activities take place without full knowledge of what, in Darwinian terms, natural selection acted upon, thereby limiting the scope of mechanistic conclusions. Advances in rational protein design and engineering have allowed...

... leucine-zipper nanostructured material peptide α-helix protein design self-assembling peptide Hierarchical self-assembly is a prerequisite for the organization of biological systems [ 1 ]. It is particularly strongly emphasized in biopolymer architectures that underpin complex cellular...