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Keywords: protein aggregation
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Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
... to the accumulation of protein aggregates in the cell and disease. Sequestration of misfolded proteins into PQC compartments represents one branch of the PQC network. In neurodegenerative diseases, certain proteins form abnormal protein deposits. Which PQC compartments house misfolded proteins associated...
Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...
Biochem Soc Trans (2017) 45 (1): 163–172.
Published: 15 February 2017
... supporting a role for kinase and GTPase activity in mediating the pathogenic effects of familial LRRK2 mutations in different model systems, with an emphasis on rodent models of PD. We also critically discuss the contribution and relevance of protein aggregation, namely of α-synuclein and tau-proteins, which...
Biochem Soc Trans (2016) 44 (5): 1531–1540.
Published: 19 October 2016
... 6 2016 28 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 amyloid formation apoptosis oligomerisation plants protein aggregation VDAC In 2007, atomic force microscopy and transmission electron microscopy...
Biochem Soc Trans (2013) 41 (6): 1613–1617.
Published: 20 November 2013
... obtained in various model systems that underscore the role of protein aggregation in the development of FUS-related proteinopathies. T.A.S. is funded by an European Molecular Biology Organization (EMBO) short-term fellowship [number ASTF 351/2011] and by the Russian Foundation for Basic Research...
Biochem Soc Trans (2012) 40 (5): 1032–1037.
Published: 19 September 2012
...Natalia Sanchez de Groot; Marc Torrent; Anna Villar-Piqué; Benjamin Lang; Salvador Ventura; Jörg Gsponer; M. Madan Babu Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic...
Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... to either of these authors (email M.F.Tuite@kent.ac.uk and C.W.Gourlay@kent.ac.uk ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...
Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
... components of the aggresome as binding partners of MSUT-2. Thus we hypothesize that MSUT-2 plays a role in the formation and/or clearance of protein aggregates. We are currently exploring the role of MSUT-2 in tauopathy using mammalian systems. The identification of sut-2 as a gene required for tau...
Biochem Soc Trans (2010) 38 (4): 1016–1020.
Published: 26 July 2010
... investigation as potential therapeutic targets in the tauopathies. 1 To whom correspondence should be addressed (email diane.hanger@kcl.ac.uk ). 8 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 dementia phosphorylation protein aggregation proteolysis...
Biochem Soc Trans (2010) 38 (1): 150–155.
Published: 19 January 2010
...Annakaisa Haapasalo; Jayashree Viswanathan; Lars Bertram; Hilkka Soininen; Rudolph E. Tanzi; Mikko Hiltunen Abnormal protein aggregation and intracellular or extracellular accumulation of misfolded and aggregated proteins are key events in the pathogenesis of different neurodegenerative diseases...
Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... are excellent potential targets to develop an effective therapy for ALS. © The Authors Journal compilation © 2008 Biochemical Society 2008 amyotrophic lateral sclerosis (ALS) Cu,Zn-superoxide dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per...
Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
Biochem Soc Trans (2005) 33 (4): 548–550.
Published: 01 August 2005
... of cell death in several different neurodegenerative diseases could be the direct production of H 2 O 2 during the early stages of protein aggregation. 1 To whom correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 31 3 2005 © 2005 The Biochemical Society 2005...