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Keywords: protein–protein interactions
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Articles
Biochem Soc Trans (2022) 50 (6): 1607–1617.
Published: 01 December 2022
... on behalf of the Biochemical Society 2022 HDX-MS hydrogen exchange hydrogen-deuterium exchange mass spectrometry intrinsically disordered proteins PI4K proteinprotein interactions A significant proportion of the human proteome is composed of regions that display a high degree...
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Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
...Giridhar Sekar; Adedolapo Ojoawo; Tudor Moldoveanu Apoptosis is a common cell death program that is important in human health and disease. Signaling in apoptosis is largely driven through proteinprotein interactions. The BCL-2 family proteins function in proteinprotein interactions as key...
Includes: Supplementary data
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Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
...Antony J. Burton; Ghaith M. Hamza; Andrew X. Zhang; Tom W. Muir Proteinprotein interactions (PPIs) in the nucleus play key roles in transcriptional regulation and ensure genomic stability. Critical to this are histone-mediated PPI networks, which are further fine-tuned through dynamic post...
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Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... of the Biochemical Society 2021 dynamic nuclear polarization membrane lipids NMR spectroscopy protein structure proteinprotein interactions transmembrane proteins Cell membranes are self-assembled structures, which enclose the principal compartments of life and define the cell as its fundamental...
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Biochem Soc Trans (2021) 49 (1): 379–391.
Published: 22 February 2021
..., making both regions candidates as sites for proteinprotein interactions and inter–lobe interface formation. We propose a sequential assembly model, whereby CESA proteins form stable trimers shortly after native folding, followed by sequential recruitment of lobes into a rosette, possibly assisted...
Articles
Biochem Soc Trans (2020) 48 (6): 2557–2564.
Published: 10 November 2020
... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . context-dependence fuzzy complexes fuzzy logic intrinsically disordered proteins proteinprotein interactions Traditionally, we consider a statement either true or false (0 or 1, Boolean logic). In our everyday life...
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Biochem Soc Trans (2020) 48 (4): 1807–1817.
Published: 13 July 2020
... incorporated. The selective reaction shows higher cross-linking efficiency, lower background and predictable cross-linking sites. It has been applied to enhance protein/peptide stability, pinpoint proteinprotein interactions, stabilize protein complexes, engineer covalent protein inhibitors, identify...
Articles
Biochem Soc Trans (2020) 48 (3): 945–954.
Published: 15 May 2020
... of the calcium-depleted state of troponin in which TNNI3 changes conformation to interact with ACTA, effectively blocking the myosin interaction site. Reproduced with permission from Chavez et al. [ 38 ]. mass spectrometry proteinprotein interactions proteome The development of new methods has...
Articles
Biochem Soc Trans (2019) 47 (6): 1949–1962.
Published: 12 December 2019
... of ubiquitin modifications is critical for both fundamental and therapeutic research. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 phosphorylation/dephosphorylation protein turnover proteinprotein interactions ubiquitin signalling ubiquitins...
Articles
Biochem Soc Trans (2019) 47 (1): 381–388.
Published: 01 February 2019
... Liang ( zxliang@ntu.edu.sg ) 14 11 2018 2 1 2019 8 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 allosteric regulation cellulose synthase cyclic di-GMP flagella PilZ domain proteinprotein interactions...
Articles
Biochem Soc Trans (2017) 45 (6): 1253–1261.
Published: 20 October 2017
... Schug ( al.schug@fz-juelich.de ) 23 6 2017 30 8 2017 4 9 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 big data analysis coevolution epistasis proteinprotein interactions signaling statistical inference...
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Biochem Soc Trans (2017) 45 (3): 599–611.
Published: 15 June 2017
... simultaneously bind two different heterotrimeric G proteins with uneven (4:2:2:2) stoichiometry [ 35 ] ( Figure 1A ). Finally, rhodopsin dimers have been observed to form higher-order assemblies in native disc membranes [ 50 ]. asymmetry protein complex proteinprotein interactions quaternary structure...
Articles
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
...-catalytic functions that can be exerted by conventional protein kinases. allosteric regulation proteinprotein interactions pseudoenzyme pseudokinases signalling Counterparts of active enzymes that lack key catalytic residues and are therefore predicted to possess defective catalytic...
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Biochem Soc Trans (2015) 43 (5): 874–880.
Published: 09 October 2015
... arrows whereas bait protein is indicated by closed arrows. affinity reagent antibody protein design proteinprotein interactions protein purification repeat protein The design and engineering of repeat proteins has been particularly successful [ 1 – 10 ]. The natural function...
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Biochem Soc Trans (2005) 33 (1): 124–126.
Published: 01 February 2005
... processes governing assembly and export of Tat-dependent enzymes. molecular chaperone molybdopterin cofactor proteinprotein interactions Tat protein transport system trimethylamine N -oxide (TMAO) reductase twin-arginine signal peptide TMAO (trimethylamine N -oxide) is a nitrogen...
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Biochem Soc Trans (2004) 32 (4): 585–588.
Published: 01 August 2004
... © 2004 The Biochemical Society 2004 initiation factors internal ribosomal entry site (IRES) phosphorylation poly(A)-binding protein (PABP) proteinprotein interactions translation The first evidence for translational surveillance was the observation that the poly(A) tail...
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Biochem Soc Trans (2001) 29 (6): 722–728.
Published: 01 November 2001
.... 1 To whom correspondence should be addressed (e-mail jhaase@tcd.ie ). 6 7 2001 © 2001 Biochemical Society 2001 neurotransmitter transporter protein trafficking protein-protein interactions CLIP, cytoplasmic linker protein CLASP, CLIP-associated protein GABA, γ...