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Keywords: protein–protein interactions
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Biochem Soc Trans (2022) BST20220206.
Published: 01 December 2022
... linkers, connecting and allowing protein-wide conformational changes between structured domains. This means IDRs influence a number of proteinprotein interactions, as well as downstream signaling pathways and protein–membrane interactions [ 8–10 ]. Because of their influence over protein conformation...
Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
...Giridhar Sekar; Adedolapo Ojoawo; Tudor Moldoveanu Apoptosis is a common cell death program that is important in human health and disease. Signaling in apoptosis is largely driven through proteinprotein interactions. The BCL-2 family proteins function in proteinprotein interactions as key...
Includes: Supplementary data
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
...Antony J. Burton; Ghaith M. Hamza; Andrew X. Zhang; Tom W. Muir Proteinprotein interactions (PPIs) in the nucleus play key roles in transcriptional regulation and ensure genomic stability. Critical to this are histone-mediated PPI networks, which are further fine-tuned through dynamic post...
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... in high resolution NMR spectra through DNP is discussed as a tool for whole cell and interaction studies. dynamic nuclear polarization membrane lipids NMR spectroscopy protein structure proteinprotein interactions transmembrane proteins Cell membranes are self-assembled structures, which...
Biochem Soc Trans (2021) 49 (3): 1337–1348.
Published: 22 June 2021
...Ewa Blaszczak; Natalia Lazarewicz; Aswani Sudevan; Robert Wysocki; Gwenaël Rabut Proteinprotein interactions (PPIs) orchestrate nearly all biological processes. They are also considered attractive drug targets for treating many human diseases, including cancers and neurodegenerative disorders...
Biochem Soc Trans (2021) 49 (1): 379–391.
Published: 22 February 2021
..., making both regions candidates as sites for proteinprotein interactions and inter–lobe interface formation. We propose a sequential assembly model, whereby CESA proteins form stable trimers shortly after native folding, followed by sequential recruitment of lobes into a rosette, possibly assisted...
Biochem Soc Trans (2020) 48 (6): 2557–2564.
Published: 10 November 2020
... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . context-dependence fuzzy complexes fuzzy logic intrinsically disordered proteins proteinprotein interactions Traditionally, we consider a statement either true or false (0 or 1, Boolean logic). In our everyday life...
Biochem Soc Trans (2020) 48 (4): 1807–1817.
Published: 13 July 2020
... incorporated. The selective reaction shows higher cross-linking efficiency, lower background and predictable cross-linking sites. It has been applied to enhance protein/peptide stability, pinpoint proteinprotein interactions, stabilize protein complexes, engineer covalent protein inhibitors, identify...
Biochem Soc Trans (2020) 48 (3): 945–954.
Published: 15 May 2020
... 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 mass spectrometry proteinprotein interactions proteome The development of new methods has paved the way for mass spectrometry (MS) to be used as a tool for structural biology [ 1 ]. MS has...
Biochem Soc Trans (2019) 47 (6): 1949–1962.
Published: 12 December 2019
... Society 2019 phosphorylation/dephosphorylation protein turnover proteinprotein interactions ubiquitin signalling ubiquitins The study of ubiquitin has continued at pace since its identification over 40 years ago [ 1 ]. However, whilst knowledge of covalent ubiquitin conjugation...
Biochem Soc Trans (2019) 47 (1): 381–388.
Published: 01 February 2019
... Society 2019 allosteric regulation cellulose synthase cyclic di-GMP flagella PilZ domain proteinprotein interactions C-di-GMP is a second messenger found in many environmental and pathogenic bacteria. C-di-GMP regulates a plethora of cellular functions and has attracted great attention...
Biochem Soc Trans (2017) 45 (6): 1253–1261.
Published: 20 October 2017
... Schug ( al.schug@fz-juelich.de ) 23 6 2017 30 8 2017 4 9 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 big data analysis coevolution epistasis proteinprotein interactions signaling statistical inference...
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
... proteinprotein interactions pseudoenzyme pseudokinases signalling Counterparts of active enzymes that lack key catalytic residues and are therefore predicted to possess defective catalytic activities, termed pseudoenzymes, are thought to comprise ∼10% of proteomes throughout the kingdoms...
Biochem Soc Trans (2017) 45 (3): 599–611.
Published: 15 June 2017
... complex proteinprotein interactions quaternary structure stoichiometry Ligand- and voltage-gated ion channels are activated by chemical and physical signals. Although these transmembrane channels typically have cyclic symmetry or pseudosymmetry [ 70 , 71 ], asymmetry often occurs through...
Biochem Soc Trans (2016) 44 (4): 994–1004.
Published: 15 August 2016
... function within signalling pathways. This information is vital for researchers to gain a more comprehensive knowledge of cellular networks which can then be used to develop new therapeutic strategies for disease. However, studying proteinprotein interactions (PPIs) can be challenging as the interactions...
Biochem Soc Trans (2016) 44 (3): 917–924.
Published: 09 June 2016
...Daniel Poglayen; Manuel Alejandro Marín-López; Jaume Bonet; Oriol Fornes; Javier Garcia-Garcia; Joan Planas-Iglesias; Joan Segura; Baldo Oliva; Narcis Fernandez-Fuentes Virtually all the biological processes that occur inside or outside cells are mediated by proteinprotein interactions (PPIs...
Biochem Soc Trans (2015) 43 (5): 874–880.
Published: 09 October 2015
... with important practical applications. 1 To whom correspondence should be addressed (email lynne.regan@yale.edu ) . 30 4 2015 © 2015 Authors; published by Portland Press Limited 2015 affinity reagent antibody protein design proteinprotein interactions protein purification repeat...
Biochem Soc Trans (2015) 43 (4): 674–679.
Published: 03 August 2015
.... Recently, a number of peptide and small molecule inhibitors of the protein-protein interaction (PPI) between Keap1 and Nrf2 have been described. These classes of compound have contrasting modes of action at the molecular level and there is emerging evidence that their biological activities have...
Biochem Soc Trans (2005) 33 (1): 124–126.
Published: 01 February 2005
... processes governing assembly and export of Tat-dependent enzymes. molecular chaperone molybdopterin cofactor proteinprotein interactions Tat protein transport system trimethylamine N -oxide (TMAO) reductase twin-arginine signal peptide TMAO (trimethylamine N -oxide) is a nitrogen...
Biochem Soc Trans (2004) 32 (4): 585–588.
Published: 01 August 2004
...) phosphorylation poly(A)-binding protein (PABP) proteinprotein interactions translation The first evidence for translational surveillance was the observation that the poly(A) tail is as important as the 5′-cap in promoting protein synthesis and that both collaborate to recruit the 40 S ribosomal...
Biochem Soc Trans (2001) 29 (6): 722–728.
Published: 01 November 2001
... 2001 Biochemical Society 2001 neurotransmitter transporter protein trafficking protein-protein interactions CLIP, cytoplasmic linker protein CLASP, CLIP-associated protein GABA, γ-aminobutync acid GAT, GABA transporter GLYT, glycine transporter GST, glutathione S-transferase 5-HT, 5...