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Keywords: protein–protein interaction
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Articles
Biochem Soc Trans (2019) 47 (5): 1393–1404.
Published: 24 September 2019
... in zebrafish and mouse. A number of proteinprotein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed...
Articles
Biochem Soc Trans (2018) 46 (1): 197–206.
Published: 06 February 2018
... ) 13 9 2017 10 12 2017 8 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational interactions intrinsically disordered proteins multiprotein complexes proteinprotein interaction quality control...
Articles
Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... on RAF-induced control of MST2 signalling by proteinprotein interactions. Finally, we recapitulate some of the direct mechanisms, such as ubiquitin-dependent degradation or gene silencing by promoter hypermethylation, involved in MST2 pathway component down-regulation in cancers. 1...
Articles
Biochem Soc Trans (2014) 42 (2): 395–400.
Published: 20 March 2014
... Journal compilation © 2014 Biochemical Society 2014 cross-linking ligand-based receptor-capture technology proteinprotein interaction receptor-like kinase signalling peptide Cell–cell communication events play a key role during developmental processes and reproduction of multicellular...
Articles
Biochem Soc Trans (2014) 42 (1): 130–138.
Published: 23 January 2014
... cellular development and differentiation [ 3 ], but when deregulated are significant mediators of tumorigenesis in various cancers [ 4 , 5 ]. Ets proteins are subclassified by the presence of further domains associated with PPIs (proteinprotein interactions) or transcriptional regulation [ 2 , 3...
Articles
Biochem Soc Trans (2013) 41 (5): 1166–1169.
Published: 23 September 2013
...Oz Sharabi; Jason Shirian; Julia M. Shifman Manipulations of PPIs (proteinprotein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain...
Articles
Biochem Soc Trans (2013) 41 (5): 1131–1136.
Published: 23 September 2013
...Nicholas Sawyer; Elizabeth B. Speltz; Lynne Regan Protein engineering is at an exciting stage because designed proteinprotein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last...
Articles
Biochem Soc Trans (2012) 40 (5): 995–999.
Published: 19 September 2012
... 2012 Calvin cycle CP12 intrinsically disordered protein proteinprotein interaction For many years, it had been thought that the ability of a protein to fulfil its cellular function depends on a well-defined three-dimensional structure. In the last decade, however, evidence has...
Articles
Biochem Soc Trans (2012) 40 (4): 624–628.
Published: 20 July 2012
...@imperial.ac.uk ). 1 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 biosensing DNA sequencing graphene nanopore protein–DNA interaction proteinprotein interaction One of the challenges of nanopore-based protein sensing is clogging of protein inside...
Articles
Biochem Soc Trans (2012) 40 (3): 523–530.
Published: 22 May 2012
... oligomerization proteinprotein interaction In all organisms, propagation of genetic material from one generation to the next requires DNA replication. The accuracy of the genetic copy and the repair of mistakes depend on balanced levels of ribonucleotides and deoxyribonucleotides [ 1 – 3 ]. One...
Articles
Biochem Soc Trans (2012) 40 (1): 124–128.
Published: 19 January 2012
... that functionally compensate for loss of their counterparts in Drosophila . Furthermore, studies in Drosophila and mammalian cell systems showed that Hippo signalling represents a kinase cascade that is tightly regulated by PPIs (proteinprotein interactions). Several Hippo signalling molecules contain SARAH...
Articles
Biochem Soc Trans (2011) 39 (5): 1327–1333.
Published: 21 September 2011
...Noha Abdel-Rahman; Alfonso Martinez-Arias; Tom L. Blundell In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the proteinprotein interactions of regulatory multiprotein assemblies...
Includes: Supplementary data
Articles
Biochem Soc Trans (2011) 39 (2): 584–588.
Published: 22 March 2011
... cleavages. 1 To whom correspondence should be addressed (email s.halford@bristol.ac.uk ). © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA looping gene therapy proteinprotein interaction recognition sequence restriction enzyme Type II restriction...
Articles
Biochem Soc Trans (2011) 39 (1): 163–168.
Published: 19 January 2011
... Biochemical Society 2011 archaeon chromosome replication DNA replication proteinprotein interaction replication machinery replisome In all forms of cellular life, chromosomal DNA replication requires the complex interplay of a large number of essential and non-essential protein factors...
Articles
Biochem Soc Trans (2010) 38 (6): 1632–1637.
Published: 24 November 2010
... The Authors Journal compilation © 2010 Biochemical Society 2010 mRNA stability phosphorylation proteinprotein interaction translation tristetraprolin (TTP) yeast two-hybrid screen Figure 1 Schematic representation of phosphorylation-dependent regulation of TTP function For details, see...
Articles
Biochem Soc Trans (2010) 38 (6): 1432–1435.
Published: 24 November 2010
... (MLIV) mucolipin proteinprotein interaction transient receptor potential mucolipin (TRPML) MLIV (mucolipidosis type IV, MIM#252650) is an LSD (lysosomal storage disorder) presenting unique features in the LSD group either in the clinical picture or the nature of the basic metabolic defect...
Articles
Biochem Soc Trans (2010) 38 (4): 947–951.
Published: 26 July 2010
...Vadim B. Vasilyev The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several proteinprotein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP...
Articles
Biochem Soc Trans (2010) 38 (4): 923–927.
Published: 26 July 2010
...@bioc.cam.ac.uk ). 10 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 blue native gel electrophoresis high-throughput screen Pearson correlation proteinprotein interaction Proteomic Complex Detection using Sedimentation (ProCoDeS) tandem affinity purification (TAP...
Articles
Biochem Soc Trans (2010) 38 (4): 901–907.
Published: 26 July 2010
... large dynamic range (dissociation constants from 10 −12 M to 10 −1 M). In the present paper, we review some of the advances that have been made in the two different types of sedimentation experiment – sedimentation equilibrium and sedimentation velocity – for the analysis of proteinprotein interactions...
Articles
Biochem Soc Trans (2010) 38 (4): 940–946.
Published: 26 July 2010
...Parvez I. Haris For most biophysical techniques, characterization of proteinprotein interactions is challenging; this is especially true with methods that rely on a physical phenomenon that is common to both of the interacting proteins. Thus, for example, in IR spectroscopy, the carbonyl vibration...
Articles
Biochem Soc Trans (2010) 38 (2): 388–394.
Published: 22 March 2010
..., control proteinprotein interactions, which in turn determine whether recombination proceeds. The present review brings together the evidence for this model derived from the studies on φC31 integrase, Bxb1 integrase and other related proteins. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2009) 37 (4): 768–771.
Published: 22 July 2009
... interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict proteinprotein interactions. In terms of functional change, the ‘rewiring...
Articles
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... 7 (Acot7) platelet glycoprotein Ibα proteinprotein interaction structural biology thrombin X-ray crystallography MX (macromolecular X-ray crystallography) is the most popular method to obtain high-resolution structural information on protein–protein complexes, and it yields the most...
Articles
Biochem Soc Trans (2008) 36 (6): 1442–1447.
Published: 19 November 2008
...–protein interaction, such that the energy barrier between desired and non-desired species is maximized. We have additionally dissected the free energy of the folding pathway of Jun–Fos variants to glean new rules that will aid in the design of stable and specific future antagonists. These rules include...
Articles
Biochem Soc Trans (2008) 36 (6): 1414–1417.
Published: 19 November 2008
...Ishu Saraogi; Andrew D. Hamilton The inhibition of proteinprotein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry...
Articles
Biochem Soc Trans (2008) 36 (6): 1422–1426.
Published: 19 November 2008
... of these authors (email thanh.haduong@univ-paris-diderot.fr or chahine@univ-paris-diderot.fr ). 29 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 fast kinetics iron acquisition proteinprotein interaction thermodynamics transferrin transferrin receptor 1...
Articles
Biochem Soc Trans (2008) 36 (3): 479–482.
Published: 21 May 2008
... addition to techniques for the investigation of proteinprotein interactions in this model organism. 1 To whom correspondence should be addressed (email d.timson@qub.ac.uk ). 28 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 bimolecular fluorescence...
Articles
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
... be addressed (email barrick@jhu.edu ). 28 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 ankyrin repeat intrinsic disorder Notch signalling proteinprotein interaction protein structure The Notch pathway is a transmembrane signal transduction pathway...
Articles
Biochem Soc Trans (2007) 35 (6): 1634–1637.
Published: 23 November 2007
...-binding complex initiation factor mRNA post-translational modification proteinprotein interaction translation regulation Gene expression can be regulated at numerous levels from alterations in the chromatin state of the gene through to transcription of DNA, processing and translation...
Articles
Biochem Soc Trans (2007) 35 (6): 1389–1392.
Published: 23 November 2007
... or inhibit proteinprotein interactions between transcription factor and co-repressor or co-activator proteins. ( C ) SUMO could promote or inhibit enzymatic activities associated with co-repressor or co-activator complexes. Before being able to investigate any of these putative mechanisms...
Articles
Biochem Soc Trans (2007) 35 (5): 966–969.
Published: 25 October 2007
...S. Rotem; C. Katz; A. Friedler ASPP (apoptosis-stimulating protein of p53) 2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. Here, we provide an overview of the structure and proteinprotein interactions of ASPP2. The C-terminus of ASPP2 contains Ank (ankyrin...
Articles
Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
.... The underlying luminal proteinprotein interactions, however, are inherently difficult to analyse, mainly due to their transient nature and the rather specialized environment of the ER. To overcome these limitations, we developed a PCA (protein fragment complementation assay) based on the citrine variant of YFP...
Articles
Biochem Soc Trans (2007) 35 (5): 835–847.
Published: 25 October 2007
.... (email fsargent@dundee.ac.uk ). 14 6 2007 membrane protein membrane transport molecular chaperone proteinprotein interaction protein targeting twin-arginine translocase The efficient targeting of proteins to their sites of physiological function is an essential feature of all...
Articles
Biochem Soc Trans (2007) 35 (5): 962–965.
Published: 25 October 2007
... molecules from large libraries. These technologies can be combined for rapid detection of protein interactions. cell-free protein synthesis protein in situ array proteinprotein interaction protein–ribosome–mRNA complex (PRM complex) proteomic technology ribosome display 1 To whom...
Articles
Biochem Soc Trans (2007) 35 (5): 1021–1026.
Published: 25 October 2007
... selective competitive inhibitor peptides and allosteric agonist peptides of individual PKC isoenzymes. The strategies and rationale used to identify these peptide regulators of proteinprotein interaction may be applicable to other signalling events. Importantly, the PKC-regulating peptides proved...
Articles
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
.... Pelletier J. Bouvier M. J. Biomol. Screen. 2005 10 463 475 15 Pfleger K.D.G. Dromey J.R. Dalrymple M.B. Lim E.M.L. Thomas W.G. Eidne K.A. Cell. Signalling 2006 18 1664 1670 The BRET technique for monitoring proteinprotein interactions has been...
Articles
Biochem Soc Trans (2007) 35 (3): 502–507.
Published: 22 May 2007
.... Furthermore, elaborate machinery exists to proofread the assembled molecules against misfolding, which is a potentially hazardous pathway implicated in severe cellular dysfunction [ 3 ]. folding degradosome membrane molecular recognition proteinprotein interaction self-assembly Cells...
Articles
Biochem Soc Trans (2007) 35 (3): 551–554.
Published: 22 May 2007
... against both wild-type and mutated proteases. They are therefore promising alternatives to active-site-directed inhibitors in AIDS therapy. Disruption of proteinprotein interactions by small molecules is a new way to obtain potentially therapeutic molecules. The actions of dimerization inhibitors...
Articles
Biochem Soc Trans (2006) 34 (6): 1054–1057.
Published: 25 October 2006
... the events of transactivation, the AR makes specific proteinprotein interactions with several basal transcription factors such as TBP (TATA-box-binding protein) and TFIIF (transcription factor IIF). These interactions occur predominantly within a defined region termed AF1 (activation function-1) located...
Articles
Biochem Soc Trans (2006) 34 (5): 679–682.
Published: 25 October 2006
.... Until recently, all protein interactions had to be determined in vitro using biochemical approaches: this biochemical legacy has provided cell biologists with the basis to test defined proteinprotein interactions not only inside cells, but now also with high spatial resolution. These techniques can...
Articles
Biochem Soc Trans (2006) 34 (5): 971–974.
Published: 25 October 2006
... The Biochemical Society 2006 folded protein guanine nucleotide dissociation inhibitor (GDI) Rho GTPase proteinprotein interaction talin vinculin Figure 1 Structure of talin-(1843–1973), showing the four-helix bundle (colouring from blue at the N-terminus to red at the C-terminus) The helix...
Articles
Biochem Soc Trans (2006) 34 (2): 317–319.
Published: 20 March 2006
... mimics may provide a foundation for the design of targeted inhibitors of DNA-binding proteins. 12 10 2005 © 2006 The Biochemical Society 2006 DNA-binding protein inhibitor DNA mimicry MfpA ocr proteinprotein interaction uracil glycosylase The interactions of proteins...
Articles
Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... change NifL–NifA system nitrogen fixation proteinprotein interaction redox regulation Figure 2 Schematic representation of the properties of NifL-R306C compared with wild-type NifL Domains and proteins are colour-coded as in Figure 1 . For simplicity, only the PAS1 domain of NifL is shown...
Articles
Biochem Soc Trans (2005) 33 (1): 105–107.
Published: 01 February 2005
... as a protein-proton antiporter [ 5 ]. 1 To whom correspondence should be addressed (email f.sargent@uea.ac.uk ). 30 9 2004 © 2005 The Biochemical Society 2005 molecular chaperone [NiFe] hydrogenase proteinprotein interaction Tat protein transport system N -oxide reductase...
Articles
Biochem Soc Trans (2004) 32 (6): 1103–1106.
Published: 26 October 2004
... fusion protein. The findings from initial experiments suggest an increase in transcription initiation and elongation rates by AR-AF1–Lex. The role of proteinprotein interactions involving co-activators and basal transcription factors and AR-AF1 activity are discussed. This work was supported...
Articles
Biochem Soc Trans (2002) 30 (4): 373–378.
Published: 01 August 2002
...M. R. Roberts; G. L. de Bruxelles 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. The target-binding domain in 14-3-3 proteins is highly conserved, suggesting similar biochemical properties for all 14-3-3s. However, higher eukaryotes possess...
Articles
Biochem Soc Trans (2002) 30 (2): 47–51.
Published: 01 April 2002
... and generating NADH in the process. In the PDH Key words: lipoic acid, lipoyl domain, protein-protein interaction, pyruvate dehydrogenase. Abbreviations used: BCDH, branched-chain 2-0x0 acid dehydm- genase; OGDH. 2-oxoglutamte dehydrogenase; E lo, 2-0x0- glutarate decarboxylase; E I p. pyruvate decarboxylase...
Articles
Biochem Soc Trans (2000) 28 (6): 615–616.
Published: 01 December 2000
... interacted with ACP in the yeast nucleus. 1 To whom correspondence should be addressed (e-mail tony.fawcett@durham.ac.uk ) 3 7 2000 © 2000 Biochemical Society 2000 enoyl-ACP reductase protein-protein interaction yeast two hybrid ACP, acyl carrier protein DES, stearoyl-ACP...