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Keywords: protein–protein interaction
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Articles
Biochem Soc Trans (2023) 51 (4): 1647–1659.
Published: 30 June 2023
... in mammals. Current knowledge, including genetic analyses of gain- and loss-of-function mutants, highlights the importance of APPs in various physiological functions. Notably, APPs consist of multiple extracellular and intracellular protein-binding regions/domains. Proteinprotein interactions are crucial...
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Biochem Soc Trans (2019) 47 (5): 1393–1404.
Published: 24 September 2019
... in zebrafish and mouse. A number of proteinprotein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed...
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Biochem Soc Trans (2018) 46 (1): 197–206.
Published: 06 February 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational interactions intrinsically disordered proteins multiprotein complexes proteinprotein interaction quality control surveillance A common theme for complex...
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Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... on RAF-induced control of MST2 signalling by proteinprotein interactions. Finally, we recapitulate some of the direct mechanisms, such as ubiquitin-dependent degradation or gene silencing by promoter hypermethylation, involved in MST2 pathway component down-regulation in cancers. 1...
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Biochem Soc Trans (2014) 42 (2): 395–400.
Published: 20 March 2014
... Journal compilation © 2014 Biochemical Society 2014 cross-linking ligand-based receptor-capture technology proteinprotein interaction receptor-like kinase signalling peptide Cell–cell communication events play a key role during developmental processes and reproduction of multicellular...
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Biochem Soc Trans (2014) 42 (1): 130–138.
Published: 23 January 2014
... cellular development and differentiation [ 3 ], but when deregulated are significant mediators of tumorigenesis in various cancers [ 4 , 5 ]. Ets proteins are subclassified by the presence of further domains associated with PPIs (proteinprotein interactions) or transcriptional regulation [ 2 , 3...
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Biochem Soc Trans (2013) 41 (5): 1166–1169.
Published: 23 September 2013
...Oz Sharabi; Jason Shirian; Julia M. Shifman Manipulations of PPIs (proteinprotein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain...
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Biochem Soc Trans (2013) 41 (5): 1131–1136.
Published: 23 September 2013
...Nicholas Sawyer; Elizabeth B. Speltz; Lynne Regan Protein engineering is at an exciting stage because designed proteinprotein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last...
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Biochem Soc Trans (2012) 40 (5): 995–999.
Published: 19 September 2012
... 2012 Calvin cycle CP12 intrinsically disordered protein proteinprotein interaction Lastly, it has been shown that CP12 specifically binds Cu 2+ and Ni 2+ ions with a low affinity (dissociation constants of 26 and 11 μM respectively). The Cu 2+ ion was able to oxidize the reduced CP12...
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Biochem Soc Trans (2012) 40 (4): 624–628.
Published: 20 July 2012
.... Linder V. Ward T.R. de Rooij N.F. Staufer U. Label-free detection of single protein molecules and proteinprotein interactions using synthetic nanopores Anal. Chem. 2008 80 4651 4658 39 Kowalczyk S.W. Hall A.R. Dekker C. Detection of local protein structures...
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Biochem Soc Trans (2012) 40 (3): 523–530.
Published: 22 May 2012
... proteinprotein interaction In all organisms, propagation of genetic material from one generation to the next requires DNA replication. The accuracy of the genetic copy and the repair of mistakes depend on balanced levels of ribonucleotides and deoxyribonucleotides [ 1 – 3 ]. One remarkable enzyme...
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Biochem Soc Trans (2011) 39 (1): 163–168.
Published: 19 January 2011
.... The ease with which many archaeal proteins can be purified in recombinant form and analysed biochemically, in isolation, has meant that relatively little attention has been paid to probing proteinprotein interactions between well-characterized components or to screening for novel interacting components...
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Biochem Soc Trans (2010) 38 (6): 1432–1435.
Published: 24 November 2010
... (MLIV) mucolipin proteinprotein interaction transient receptor potential mucolipin (TRPML) MLIV (mucolipidosis type IV, MIM#252650) is an LSD (lysosomal storage disorder) presenting unique features in the LSD group either in the clinical picture or the nature of the basic metabolic defect...
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Biochem Soc Trans (2010) 38 (4): 947–951.
Published: 26 July 2010
...Vadim B. Vasilyev The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several proteinprotein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP...
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Biochem Soc Trans (2010) 38 (2): 388–394.
Published: 22 March 2010
..., control proteinprotein interactions, which in turn determine whether recombination proceeds. The present review brings together the evidence for this model derived from the studies on φC31 integrase, Bxb1 integrase and other related proteins. 1 To whom correspondence should be addressed (email...
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Biochem Soc Trans (2009) 37 (4): 768–771.
Published: 22 July 2009
... interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict proteinprotein interactions. In terms of functional change, the ‘rewiring...
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Biochem Soc Trans (2008) 36 (6): 1414–1417.
Published: 19 November 2008
...Ishu Saraogi; Andrew D. Hamilton The inhibition of proteinprotein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry...
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Biochem Soc Trans (2008) 36 (6): 1422–1426.
Published: 19 November 2008
... of these authors (email thanh.haduong@univ-paris-diderot.fr or chahine@univ-paris-diderot.fr ). 29 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 fast kinetics iron acquisition proteinprotein interaction thermodynamics transferrin transferrin receptor 1...
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Biochem Soc Trans (2008) 36 (6): 1442–1447.
Published: 19 November 2008
...-1 (AP-1) basic leucine zipper (bZIP) interfering peptide protein-fragment complementation assay (PCA) proteinprotein interaction semi-rational design Is it possible to design proteins that can recognize and bind to each other in both a stable and specific manner? Answering...
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Biochem Soc Trans (2008) 36 (3): 479–482.
Published: 21 May 2008
... addition to techniques for the investigation of proteinprotein interactions in this model organism. 1 To whom correspondence should be addressed (email d.timson@qub.ac.uk ). 28 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 bimolecular fluorescence...
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Biochem Soc Trans (2007) 35 (6): 1389–1392.
Published: 23 November 2007
... of HSF1 (heat-shock transcription factor 1), conjugation of SUMO in fact stimulates the ability of HSF1 to bind DNA and therefore presumably its capacity to regulate genes that respond to heat shock [ 3 ]. Alternatively, SUMOylation could promote or inhibit proteinprotein interactions, leading...
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Biochem Soc Trans (2007) 35 (5): 835–847.
Published: 25 October 2007
... proteinprotein interaction protein targeting twin-arginine translocase The efficient targeting of proteins to their sites of physiological function is an essential feature of all biological systems. The Tat (twin-arginine transport) system is a protein-targeting pathway found in all kingdoms...
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Biochem Soc Trans (2007) 35 (5): 962–965.
Published: 25 October 2007
... compilation © 2007 Biochemical Society 2007 cell-free protein synthesis protein in situ array proteinprotein interaction protein–ribosome–mRNA complex (PRM complex) proteomic technology ribosome display Signalling: A Focus Topic at Life Sciences 2007, held at SECC Glasgow, U.K., 9–12...
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Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
.... The underlying luminal proteinprotein interactions, however, are inherently difficult to analyse, mainly due to their transient nature and the rather specialized environment of the ER. To overcome these limitations, we developed a PCA (protein fragment complementation assay) based on the citrine variant of YFP...
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Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
.... Dalrymple M.B. Lim E.M.L. Thomas W.G. Eidne K.A. Cell. Signalling 2006 18 1664 1670 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging proteinprotein interaction There are clearly important...
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Biochem Soc Trans (2007) 35 (3): 502–507.
Published: 22 May 2007
... in which a synthetic detergent can assemble into membrane layers. 1 To whom correspondence should be addressed (email bfl20@mole.bio.cam.ac.uk ). 9 1 2007 © 2007 Biochemical Society 2007 folding degradosome membrane molecular recognition proteinprotein interaction self...
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Biochem Soc Trans (2007) 35 (3): 551–554.
Published: 22 May 2007
... against both wild-type and mutated proteases. They are therefore promising alternatives to active-site-directed inhibitors in AIDS therapy. Disruption of proteinprotein interactions by small molecules is a new way to obtain potentially therapeutic molecules. 1 To whom correspondence should...
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Biochem Soc Trans (2006) 34 (2): 317–319.
Published: 20 March 2006
... DNA-binding protein inhibitor DNA mimicry MfpA ocr proteinprotein interaction uracil glycosylase The interactions of proteins, and particularly of enzymes, with DNA are tightly controlled spatially and temporally to ensure appropriate treatment of the genome. A classical method...
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Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... to signal perception. Azotobacter vinelandii conformational change NifL–NifA system nitrogen fixation proteinprotein interaction redox regulation © 2006 The Biochemical Society 2006 6 9 2005 2 To whom correspondence should be addressed (email ray.dixon@bbsrc.ac.uk...
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Biochem Soc Trans (2005) 33 (1): 105–107.
Published: 01 February 2005
... molecular chaperone [NiFe] hydrogenase proteinprotein interaction Tat protein transport system N -oxide reductase twin-arginine signal peptide Escherichia coli displays a remarkable flexibility in its respiratory electron transport processes. As an obligate anaerobe, E. coli can utilize...
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Biochem Soc Trans (2004) 32 (6): 1103–1106.
Published: 26 October 2004
... fusion protein. The findings from initial experiments suggest an increase in transcription initiation and elongation rates by AR-AF1–Lex. The role of proteinprotein interactions involving co-activators and basal transcription factors and AR-AF1 activity are discussed. 1 To whom correspondence...
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Biochem Soc Trans (2002) 30 (4): 373–378.
Published: 01 August 2002
...M. R. Roberts; G. L. de Bruxelles 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. The target-binding domain in 14-3-3 proteins is highly conserved, suggesting similar biochemical properties for all 14-3-3s. However, higher eukaryotes possess...
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Biochem Soc Trans (2002) 30 (2): 47–51.
Published: 01 April 2002
..., pyruvate decarboxylase E2p, dihydrolipoyl acetyltransferase E2o, dihydrolipoyl succinyltransferase E3, dihydrolipoyl dehydrogenase PDH, pyruvate dehydrogenase T 2 , transverse relaxation time lipoic acid lipoyl domain protein-protein interaction pyruvate dehydrogenase Metabolite...
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Biochem Soc Trans (2000) 28 (6): 615–616.
Published: 01 December 2000
... interacted with ACP in the yeast nucleus. © 2000 Biochemical Society 2000 enoyl-ACP reductase protein-protein interaction yeast two hybrid ACP, acyl carrier protein DES, stearoyl-ACP desaturase ENR enoyl-ACP reductase FAS, fatty acid synthase TE, acyl-ACP thioesterase Fatty Acid...