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1-49 of 49
Keywords: protein–protein interaction
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1647–1659.
Published: 30 June 2023
... in mammals. Current knowledge, including genetic analyses of gain- and loss-of-function mutants, highlights the importance of APPs in various physiological functions. Notably, APPs consist of multiple extracellular and intracellular protein-binding regions/domains. Protein–protein interactions are crucial...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1393–1404.
Published: 24 September 2019
... in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 197–206.
Published: 06 February 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational interactions intrinsically disordered proteins multiprotein complexes protein–protein interaction quality control surveillance A common theme for complex...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... on RAF-induced control of MST2 signalling by protein–protein interactions. Finally, we recapitulate some of the direct mechanisms, such as ubiquitin-dependent degradation or gene silencing by promoter hypermethylation, involved in MST2 pathway component down-regulation in cancers. 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 395–400.
Published: 20 March 2014
... Journal compilation © 2014 Biochemical Society 2014 cross-linking ligand-based receptor-capture technology protein–protein interaction receptor-like kinase signalling peptide Cell–cell communication events play a key role during developmental processes and reproduction of multicellular...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 130–138.
Published: 23 January 2014
... cellular development and differentiation [ 3 ], but when deregulated are significant mediators of tumorigenesis in various cancers [ 4 , 5 ]. Ets proteins are subclassified by the presence of further domains associated with PPIs (protein–protein interactions) or transcriptional regulation [ 2 , 3...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1166–1169.
Published: 23 September 2013
...Oz Sharabi; Jason Shirian; Julia M. Shifman Manipulations of PPIs (protein–protein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1131–1136.
Published: 23 September 2013
...Nicholas Sawyer; Elizabeth B. Speltz; Lynne Regan Protein engineering is at an exciting stage because designed protein–protein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 995–999.
Published: 19 September 2012
... 2012 Calvin cycle CP12 intrinsically disordered protein protein–protein interaction Lastly, it has been shown that CP12 specifically binds Cu 2+ and Ni 2+ ions with a low affinity (dissociation constants of 26 and 11 μM respectively). The Cu 2+ ion was able to oxidize the reduced CP12...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 624–628.
Published: 20 July 2012
.... Linder V. Ward T.R. de Rooij N.F. Staufer U. Label-free detection of single protein molecules and protein–protein interactions using synthetic nanopores Anal. Chem. 2008 80 4651 4658 39 Kowalczyk S.W. Hall A.R. Dekker C. Detection of local protein structures...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (3): 523–530.
Published: 22 May 2012
... protein–protein interaction In all organisms, propagation of genetic material from one generation to the next requires DNA replication. The accuracy of the genetic copy and the repair of mistakes depend on balanced levels of ribonucleotides and deoxyribonucleotides [ 1 – 3 ]. One remarkable enzyme...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 124–128.
Published: 19 January 2012
... that functionally compensate for loss of their counterparts in Drosophila . Furthermore, studies in Drosophila and mammalian cell systems showed that Hippo signalling represents a kinase cascade that is tightly regulated by PPIs (protein–protein interactions). Several Hippo signalling molecules contain SARAH...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1327–1333.
Published: 21 September 2011
...Noha Abdel-Rahman; Alfonso Martinez-Arias; Tom L. Blundell In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein–protein interactions of regulatory multiprotein assemblies...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 584–588.
Published: 22 March 2011
.... Quantification of zinc finger nuclease-associated toxicity Methods Mol. Biol. 2010 649 237 245 2 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA looping gene therapy protein–protein interaction recognition sequence restriction enzyme...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 163–168.
Published: 19 January 2011
.... The ease with which many archaeal proteins can be purified in recombinant form and analysed biochemically, in isolation, has meant that relatively little attention has been paid to probing protein–protein interactions between well-characterized components or to screening for novel interacting components...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1632–1637.
Published: 24 November 2010
... The Authors Journal compilation © 2010 Biochemical Society 2010 mRNA stability phosphorylation protein–protein interaction translation tristetraprolin (TTP) yeast two-hybrid screen ARE AU-rich element IL interleukin IP immunoprecipitation LPS lipopolysaccharide...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1432–1435.
Published: 24 November 2010
... (MLIV) mucolipin protein–protein interaction transient receptor potential mucolipin (TRPML) MLIV (mucolipidosis type IV, MIM#252650) is an LSD (lysosomal storage disorder) presenting unique features in the LSD group either in the clinical picture or the nature of the basic metabolic defect...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 947–951.
Published: 26 July 2010
...Vadim B. Vasilyev The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several protein–protein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 923–927.
Published: 26 July 2010
... blue native gel electrophoresis high-throughput screen Pearson correlation protein–protein interaction Proteomic Complex Detection using Sedimentation (ProCoDeS) tandem affinity purification (TAP) Recently, several techniques have been described that use similar principles to ProCoDeS. Dong...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 901–907.
Published: 26 July 2010
... large dynamic range (dissociation constants from 10 −12 M to 10 −1 M). In the present paper, we review some of the advances that have been made in the two different types of sedimentation experiment – sedimentation equilibrium and sedimentation velocity – for the analysis of protein–protein interactions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 940–946.
Published: 26 July 2010
...Parvez I. Haris For most biophysical techniques, characterization of protein–protein interactions is challenging; this is especially true with methods that rely on a physical phenomenon that is common to both of the interacting proteins. Thus, for example, in IR spectroscopy, the carbonyl vibration...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 388–394.
Published: 22 March 2010
..., control protein–protein interactions, which in turn determine whether recombination proceeds. The present review brings together the evidence for this model derived from the studies on φC31 integrase, Bxb1 integrase and other related proteins. 1 To whom correspondence should be addressed (email...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 768–771.
Published: 22 July 2009
... interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict protein–protein interactions. In terms of functional change, the ‘rewiring...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1414–1417.
Published: 19 November 2008
...Ishu Saraogi; Andrew D. Hamilton The inhibition of protein–protein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1422–1426.
Published: 19 November 2008
... of these authors (email thanh.haduong@univ-paris-diderot.fr or chahine@univ-paris-diderot.fr ). 29 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 fast kinetics iron acquisition protein–protein interaction thermodynamics transferrin transferrin receptor 1...
Articles
Bostjan Kobe, Gregor Guncar, Rebecca Buchholz, Thomas Huber, Bohumil Maco, Nathan Cowieson, Jennifer L. Martin, Mary Marfori, Jade K. Forwood
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... structures solved by different groups, before concluding in the ‘Outlook’ section. © The Authors Journal compilation © 2008 Biochemical Society 2008 acyl-CoA thioesterase 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1442–1447.
Published: 19 November 2008
...-1 (AP-1) basic leucine zipper (bZIP) interfering peptide protein-fragment complementation assay (PCA) protein–protein interaction semi-rational design Is it possible to design proteins that can recognize and bind to each other in both a stable and specific manner? Answering...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 479–482.
Published: 21 May 2008
... addition to techniques for the investigation of protein–protein interactions in this model organism. 1 To whom correspondence should be addressed (email d.timson@qub.ac.uk ). 28 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 bimolecular fluorescence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
... be addressed (email barrick@jhu.edu ). 28 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 ankyrin repeat intrinsic disorder Notch signalling protein–protein interaction protein structure The Notch pathway is a transmembrane signal transduction pathway...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1634–1637.
Published: 23 November 2007
... modification protein–protein interaction translation regulation ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1389–1392.
Published: 23 November 2007
... of HSF1 (heat-shock transcription factor 1), conjugation of SUMO in fact stimulates the ability of HSF1 to bind DNA and therefore presumably its capacity to regulate genes that respond to heat shock [ 3 ]. Alternatively, SUMOylation could promote or inhibit protein–protein interactions, leading...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 835–847.
Published: 25 October 2007
... protein–protein interaction protein targeting twin-arginine translocase The efficient targeting of proteins to their sites of physiological function is an essential feature of all biological systems. The Tat (twin-arginine transport) system is a protein-targeting pathway found in all kingdoms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 962–965.
Published: 25 October 2007
... compilation © 2007 Biochemical Society 2007 cell-free protein synthesis protein in situ array protein–protein interaction protein–ribosome–mRNA complex (PRM complex) proteomic technology ribosome display Signalling: A Focus Topic at Life Sciences 2007, held at SECC Glasgow, U.K., 9–12...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1021–1026.
Published: 25 October 2007
... selective competitive inhibitor peptides and allosteric agonist peptides of individual PKC isoenzymes. The strategies and rationale used to identify these peptide regulators of protein–protein interaction may be applicable to other signalling events. Importantly, the PKC-regulating peptides proved...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 966–969.
Published: 25 October 2007
...S. Rotem; C. Katz; A. Friedler ASPP (apoptosis-stimulating protein of p53) 2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. Here, we provide an overview of the structure and protein–protein interactions of ASPP2. The C-terminus of ASPP2 contains Ank (ankyrin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
.... The underlying luminal protein–protein interactions, however, are inherently difficult to analyse, mainly due to their transient nature and the rather specialized environment of the ER. To overcome these limitations, we developed a PCA (protein fragment complementation assay) based on the citrine variant of YFP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
.... Dalrymple M.B. Lim E.M.L. Thomas W.G. Eidne K.A. Cell. Signalling 2006 18 1664 1670 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein interaction There are clearly important...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 502–507.
Published: 22 May 2007
... in which a synthetic detergent can assemble into membrane layers. 1 To whom correspondence should be addressed (email bfl20@mole.bio.cam.ac.uk ). 9 1 2007 © 2007 Biochemical Society 2007 folding degradosome membrane molecular recognition protein–protein interaction self...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 551–554.
Published: 22 May 2007
... against both wild-type and mutated proteases. They are therefore promising alternatives to active-site-directed inhibitors in AIDS therapy. Disruption of protein–protein interactions by small molecules is a new way to obtain potentially therapeutic molecules. 1 To whom correspondence should...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1054–1057.
Published: 25 October 2006
... the events of transactivation, the AR makes specific protein–protein interactions with several basal transcription factors such as TBP (TATA-box-binding protein) and TFIIF (transcription factor IIF). These interactions occur predominantly within a defined region termed AF1 (activation function-1) located...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 679–682.
Published: 25 October 2006
.... Until recently, all protein interactions had to be determined in vitro using biochemical approaches: this biochemical legacy has provided cell biologists with the basis to test defined protein–protein interactions not only inside cells, but now also with high spatial resolution. These techniques can...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 971–974.
Published: 25 October 2006
... The Biochemical Society 2006 folded protein guanine nucleotide dissociation inhibitor (GDI) Rho GTPase protein–protein interaction talin vinculin There are now many examples of ‘intrinsically disordered’ proteins [ 1 , 2 ], including proteins involved in cell-cycle regulation, signal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (2): 317–319.
Published: 20 March 2006
... DNA-binding protein inhibitor DNA mimicry MfpA ocr protein–protein interaction uracil glycosylase The interactions of proteins, and particularly of enzymes, with DNA are tightly controlled spatially and temporally to ensure appropriate treatment of the genome. A classical method...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... to signal perception. Azotobacter vinelandii conformational change NifL–NifA system nitrogen fixation protein–protein interaction redox regulation © 2006 The Biochemical Society 2006 6 9 2005 2 To whom correspondence should be addressed (email ray.dixon@bbsrc.ac.uk...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 105–107.
Published: 01 February 2005
... molecular chaperone [NiFe] hydrogenase protein–protein interaction Tat protein transport system N -oxide reductase twin-arginine signal peptide Escherichia coli displays a remarkable flexibility in its respiratory electron transport processes. As an obligate anaerobe, E. coli can utilize...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1103–1106.
Published: 26 October 2004
... fusion protein. The findings from initial experiments suggest an increase in transcription initiation and elongation rates by AR-AF1–Lex. The role of protein–protein interactions involving co-activators and basal transcription factors and AR-AF1 activity are discussed. 1 To whom correspondence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 373–378.
Published: 01 August 2002
...M. R. Roberts; G. L. de Bruxelles 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. The target-binding domain in 14-3-3 proteins is highly conserved, suggesting similar biochemical properties for all 14-3-3s. However, higher eukaryotes possess...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (2): 47–51.
Published: 01 April 2002
..., pyruvate decarboxylase E2p, dihydrolipoyl acetyltransferase E2o, dihydrolipoyl succinyltransferase E3, dihydrolipoyl dehydrogenase PDH, pyruvate dehydrogenase T 2 , transverse relaxation time lipoic acid lipoyl domain protein-protein interaction pyruvate dehydrogenase Metabolite...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (6): 615–616.
Published: 01 December 2000
... interacted with ACP in the yeast nucleus. © 2000 Biochemical Society 2000 enoyl-ACP reductase protein-protein interaction yeast two hybrid ACP, acyl carrier protein DES, stearoyl-ACP desaturase ENR enoyl-ACP reductase FAS, fatty acid synthase TE, acyl-ACP thioesterase Fatty Acid...
