...) regulation of COX-2 involves alternative polyadenylation. alternative polyadenylation cyclo-oxygenase-2 (COX-2) mRNA stability prostaglandin transcription 3′-untranslated region COXs (cyclo-oxygenases), COX-1 and COX-2, are key regulatory enzymes involved in the production of prostaglandins...

... increase the expression of COX-2 (cyclooxygenase-2), itself an NF-κB controlled gene. The first wave causes the production of inflammatory mediators such as PGE 2 (prostaglandin E 2 ), allowing the establishment of inflammation. The second wave causes the synthesis of PGD 2 and its metabolites that induce...

...) inhibitor or as an agonist of the peroxisome-proliferator-activator receptor (PPAR) γ in the ApoE −/− mouse model. In vitro , a 9- cis , 11- trans isomer of CLA inhibited prostaglandin formation and oxygen consumption by both isoforms of COX, with no evidence by MS of alternative products being generated...