... 4 2015 © 2015 Authors; published by Portland Press Limited 2015 forkhead box P3 (FOXP3) lymphocytes proliferation regulatory T-cells tribbles-1 (TRIB1) Tribbles pseudokinase 1 (TRIB1) is a serine-threonine kinase-like protein with no known catalytic activity which has been...

... cancer dual-specificity phosphatase (DUSP) immunity mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase phosphatase 2 (MKP-2) phosphatase proliferation The explosion in the delineation of intracellular kinase signalling pathways in the last 25 years has been exemplified...

... pluripotency, proliferation and differentiation (i.e. cell fate) need to be understood so that pluripotency can be maintained during expansion, while differentiation to specific lineages can be induced accurately when required. The present review focuses on the potential roles that PI3K (phosphoinositide 3...

..., proliferation and survival. In the present paper, we review recent evidence highlighting the notion that the TSC1/2 complex simultaneously controls mTOR-dependent and mTOR-independent signals critical for the balancing of cell proliferation and cell death. 1 To whom correspondence should be addressed...

... kinase) kinase] and ERK phosphorylation leading to an increase in cell proliferation, cell survival, transformation, tumorigenicity, invasion and vascular development. Many of these hallmarks of cancer can be reversed by treatment of cells with siRNA (small interfering RNA) to BRAF or by inhibiting MEK...

... the normal maintenance of this tissue: differentiation, migration, proliferation and apoptosis. Indeed, APC is involved in the regulation of β-catenin and it also is an important regulator of the cytoskeleton. Thus mutations in APC lead to the accumulation of β-catenin, which causes changes...

... differentiation growth factor receptor lysophosphatidic acid p42/p44 mitogen-activated protein kinase proliferation sphingosine 1-phosphate (S1P) Abbreviations used: ASM, airway smooth muscle; GPCR, G-protein-coupled receptor; GRK2, G-protein-coupled receptor kinase 2; IGF-1, insulin-like growth...