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Keywords: prion protein (PrP)
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Articles

Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration

Julie A. Moreno, Giovanna R. Mallucci
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 482–487.
https://doi.org/10.1042/BST0380482
Published: 22 March 2010
... neurodegeneration neurophysiology prion protein (PrP) synaptic dysfunction As the focus for the pathological findings and their reversal was the hippocampus, we tested prion-infected animals in behavioural tasks known to depend on hippocampal integrity in vivo , and we measured synaptic transmission...
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Articles

The transmissible spongiform encephalopathies: emerging and declining epidemics

J.C. Manson, E. Cancellotti, P. Hart, M.T. Bishop, R.M. Barron
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1155–1158.
https://doi.org/10.1042/BST0341155
Published: 25 October 2006
... and 196. bovine spongiform encephalopathy (BSE) chronic wasting disease (CWD) Creutzfeldt–Jakob disease (CJD) prion protein (PrP) scrapie transmissible spongiform encephalopathy (TSE) Since 1986, when BSE was first recognized, approx. 180000 cattle in the U.K. have developed...
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Articles

Reactive oxygen species (ROS)-mediated β-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress

N.T. Watt, N.M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1123–1125.
https://doi.org/10.1042/BST0331123
Published: 26 October 2005
..., C2 is not formed upon exposure of the cells to ROS, whilst C1 is formed normally. neurodegeneration octapeptide repeat oxidative stress prion protein (PrP) proteolysis reactive oxygen species (ROS) Prion diseases occur when a conformational conversion in the normal PrP C...
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