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Keywords: prion protein
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Biochem Soc Trans (2008) 36 (6): 1288–1292.
Published: 19 November 2008
... to affect Cu 2+ delivery [ 7 ]. Although the normal function of the prion protein has yet to be established, the ability of PrP c to bind Cu 2+ in vivo suggests a role in Cu 2+ homoeostasis [ 8 ]. Cu 2+ can induce cleavage of the PrP main chain [ 9 ]. Interestingly, different protease profiles...
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Articles
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... the prion protein associated with spongiform encephalopathies, and the amyloid-β (Aβ) peptide associated with Alzheimer's disease. For Aβ and SP-C, removal of the helix/strand discordance by residue replacements abrogates fibril formation in vitro. 1 e-mail jan.johansson@mbb.ki.se 26 2 2001...