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Keywords: post-translational modification
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Articles
Biochem Soc Trans (2022) 50 (1): 13–20.
Published: 15 February 2022
...- and enrichment strategies to unravel enzyme-substrate relationships ( Figure 2 ). It is primarily used in the signalling field to investigate post-translational modifications like phosphorylation, ubiquitylation and less studied PTMs including acetylation, methylation, citrullination and other modifications like...
Articles
Biochem Soc Trans (2021) 49 (4): 1711–1721.
Published: 05 August 2021
...–pathogen interactions that affect the IFN response. ADP-ribosylation is an underexplored post-translational modification catalyzed by ADP-ribosyl transferases collectively termed poly(ADP-ribose) polymerases (PARPs). Several human PARPs are induced by the IFN response and participate in antiviral defences...
Articles
Biochem Soc Trans (2020) 48 (4): 1297–1308.
Published: 21 August 2020
... could stabilise or destabilise the intercellular complexes and lead to their sorting into polarised distributions within cells. Post-translational modifications are key regulators of molecular interactions between proteins. Several post-translational modifications of core proteins have been reported...
Articles
Biochem Soc Trans (2020) 48 (4): 1737–1750.
Published: 17 July 2020
...Thomas R. Cotton; Bernhard C. Lechtenberg Ubiquitination is a fundamental post-translational modification that regulates almost all aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases. The RING-between-RING (RBR) family of E3 ligases encompasses 14...
Articles
Biochem Soc Trans (2020) 48 (2): 441–449.
Published: 22 April 2020
...Theo Rein Adaptation to stress is a fundamental requirement to cope with changing environmental conditions that pose a threat to the homeostasis of cells and organisms. Post-translational modifications (PTMs) of proteins represent a possibility to quickly produce proteins with new features...
Articles
Biochem Soc Trans (2020) 48 (2): 479–497.
Published: 20 March 2020
... the scope of this review, we refer readers to many recent reviews that comprehensively summarize recent progress in this field [ 77–84 ]. chemical probe drug development inhibitor post-translational modification PROTAC ubiquitin Ubiquitination is indispensable for the survival of all...
Articles
Biochem Soc Trans (2019) 47 (1): 469–476.
Published: 19 February 2019
... findings on a novel mode of redox regulation involving covalent modification of cellular proteins by CoA, termed protein CoAlation. coenzyme A low-molecular-weight thiols post-translational modification protein CoAlation reactive oxygen species redox regulation in bacteria © 2019 The Author...
Articles
Biochem Soc Trans (2018) 46 (5): 1161–1169.
Published: 28 August 2018
... indicated that this post-translational modification is widespread in prokaryotes and is even found in some eukaryotes. Flavin transferase can occur as a separate ∼40 kDa protein or as a domain within the target protein and recognizes a degenerate DgxtsA T / S motif in various target proteins. The purpose...
Includes: Supplementary data
Articles
Biochem Soc Trans (2018) 46 (3): 721–728.
Published: 25 May 2018
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . coenzyme A metabolic control analysis oxidation–reduction post-translational modification Coenzyme A (CoA) is a fundamental cofactor in all living...
Articles
Biochem Soc Trans (2017) 45 (5): 1125–1136.
Published: 12 September 2017
...Sarah Darling; Andrew B. Fielding; Dorota Sabat-Pośpiech; Ian A. Prior; Judy M. Coulson Post-translational modification of proteins by ubiquitylation is increasingly recognised as a highly complex code that contributes to the regulation of diverse cellular processes. In humans, a family of almost...
Articles
Biochem Soc Trans (2017) 45 (4): 871–884.
Published: 03 July 2017
... involves both transcriptional and post-translational mechanisms. Nuclear receptors exemplify the transcriptional programs that couple molecular clocks to metabolism. The post-translational modifications of the core clock machinery are known to play a key role in metabolic entrainment of circadian clocks. O...
Articles
Biochem Soc Trans (2017) 45 (4): 923–928.
Published: 16 June 2017
... residues is a post-translational modification (PTM) that is conserved from yeast to humans. Commonly referred to as protein S-palmitoylation, this PTM is one of several types of fatty acylation that occurs in eukaryotic cells [ 1 , 2 ]. The catalog of S-palmitoylated proteins has grown dramatically...
Articles
Biochem Soc Trans (2016) 44 (6): 1581–1602.
Published: 02 December 2016
...Paul R. Elliott The post-translational modification of proteins provides a rapid and versatile system for regulating all signalling pathways. Protein ubiquitination is one such type of post-translational modification involved in controlling numerous cellular processes. The unique ability...
Articles
Biochem Soc Trans (2016) 44 (5): 1305–1312.
Published: 19 October 2016
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer dual-specificity phosphatases metastasis post-translational modification protein phosphatases PTP4A3 The phosphatase of regenerating liver (PRL)-3 protein belongs to the PRL subfamily, which...
Articles
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
...Riccardo Trapannone; Karim Rafie; Daan M.F. van Aalten The O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (O-GlcNAcylation) is the dynamic and reversible attachment of N -acetylglucosamine to serine and threonine residues of nucleocytoplasmic target proteins. It is abundant...
Articles
Biochem Soc Trans (2015) 43 (6): 1241–1246.
Published: 27 November 2015
... ). 24 7 2015 © 2015 Authors; published by Portland Press Limited 2015 alternative splicing cold shock domain containing protein E1 (CSDE1) N-ras post-translational modification translation upstream of N-ras (Unr) Unr [upstream of N-ras; also known as cold shock domain (CSD...
Articles
Biochem Soc Trans (2015) 43 (6): 1285–1295.
Published: 27 November 2015
...Tajekesa K.P. Blee; Nicola K. Gray; Matthew Brook Post-transcriptional control of gene expression is critical for normal cellular function and viability and many of the proteins that mediate post-transcriptional control are themselves subject to regulation by post-translational modification (PTM...
Articles
Biochem Soc Trans (2015) 43 (2): 262–267.
Published: 07 April 2015
... Correspondence may be addressed to either of these authors (email: e.tate@imperial.ac.uk or t.magee@imperial.ac.uk ). 28 1 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 cholesterylation hedgehog protein bioorthogonal lipid probes post-translational modification...
Articles
Biochem Soc Trans (2015) 43 (2): 253–261.
Published: 07 April 2015
... chemical proteomics chemical reporters fatty-acylation post-translational modification protein acylation Protein acylation, the post-translational and covalent attachment of acyl groups to proteins, is a widespread protein modification ( Figure 1 ). The reaction is generally catalysed by acyl...
Articles
Biochem Soc Trans (2013) 41 (4): 1072–1077.
Published: 18 July 2013
...Tom E. McAllister; Jeffrey J. Hollins; Michael E. Webb Phosphorylation is a ubiquitous protein post-translational modification, and the importance of phosphorylation of serine, threonine and tyrosine is well established. What is lesser known is that almost all heteroatom-containing amino acids can...
Articles
Biochem Soc Trans (2013) 41 (3): 761–768.
Published: 23 May 2013
...-translational modifications to proteins, a mechanistic understanding of the regulation of biological processes is fostered by loss-of-function studies both in vitro and in vivo . For peptidylprolyl isomerases, this can be accomplished with small-molecule inhibitors with high affinity for the isomerase active...
Articles
Biochem Soc Trans (2013) 41 (3): 751–759.
Published: 23 May 2013
... not function alone, but work together in various combinations, and cross-regulate each other in a manner that diversifies their functional states. Arginine methylation is one of the numerous PTMs (post-translational modifications) occurring on histones, catalysed by a family of PRMTs (protein arginine...
Articles
Biochem Soc Trans (2013) 41 (1): 43–49.
Published: 29 January 2013
...Brent R. Martin Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory...
Articles
Biochem Soc Trans (2013) 41 (1): 432–435.
Published: 29 January 2013
... this situation. A combination of bioinformatics, molecular biology, biochemical and mass spectrometry approaches have served to delineate the Agl pathway responsible for N-glycosylation of the S-layer glycoprotein, a reporter of this post-translational modification in Hfx. volcanii . More recently, differential...
Articles
Biochem Soc Trans (2012) 40 (6): 1456–1462.
Published: 21 November 2012
... by Escherichia coli and related enterobacteria through the ribosomal pathway. They are synthesized as linear precursors, which can further undergo complex post-translational modifications resulting from dedicated maturation enzymes encoded in the microcin gene clusters, and are processed by proteolytic cleavage...
Articles
Biochem Soc Trans (2012) 40 (6): 1539–1543.
Published: 21 November 2012
... , 8 ]: mcjA encodes the linear 58-amino-acid precursor of MccJ25 that is ribosomally synthesized, mcjB and mcjC encode proteins involved in the post-translational modification of McjA to the lasso structure [ 9 ], and mcjD encodes an ABC (ATP-binding-cassette) transporter that is required...
Articles
Biochem Soc Trans (2010) 38 (1): 98–103.
Published: 19 January 2010
... of post-translational modifications, thanks to a variety of ‘modifiers’, including ubiquitylation E3s and acetyltransferases, that fine-tune the stability and activity of the protein. Work of the last few years has revealed that, in addition to targeting p53, these modifiers also modify each other...
Articles
Biochem Soc Trans (2008) 36 (5): 874–878.
Published: 19 September 2008
...Denis Tempé; Marc Piechaczyk; Guillaume Bossis During the last decade, SUMOylation has emerged as a central regulatory post-translational modification in the control of the fate and function of proteins. However, how SUMOylation is regulated itself has just started to be delineated. It appears now...
Articles
Biochem Soc Trans (2008) 36 (5): 853–857.
Published: 19 September 2008
... of the ubiquitin family occurs at various levels, imposing overlapping controls of security of intriguing complexity. The formation of active macromolecular complexes such as the IKK [IκB (inhibitory κB) kinase] complex is tightly regulated by these post-translational modifications probably due to the fact...
Articles
Biochem Soc Trans (2008) 36 (5): 1037–1044.
Published: 19 September 2008
... mass spectrometry 4-hydroxynonenal (4HNE) lipoprotein oxidative stress post-translational modification protein oxidation PTMs (post-translational modifications) of proteins occur extensively throughout their lifetime in a cell. For certain proteins, rather than the addition of a modifying...
Articles
Biochem Soc Trans (2008) 36 (3): 445–448.
Published: 21 May 2008
...Terence A. Agbor; Cormac T. Taylor Post-translational modification is a critical event in the dynamic regulation of protein stability, location, structure, function, activity and interaction with other proteins and as such plays an important role in organism complexity. Over the last 10 years...
Articles
Biochem Soc Trans (2007) 35 (6): 1634–1637.
Published: 23 November 2007
... state of the gene through to transcription of DNA, processing and translation of the mRNA to post-translational modification of the protein. At the post-transcriptional level, translation of mRNA is a key target of regulation by 5′- and 3′-UTR (untranslated region)-binding factors [ 1 ]. In specialized...
Articles
Biochem Soc Trans (2007) 35 (2): 261–262.
Published: 20 March 2007
... κB PTM post-translational modification SLPI secretory leucocyte protease inhibitor References 1 Ghosh S. May M.J. Kopp E.B. Annu. Rev. Immunol. 1998 16 225 260 2 Hayden M.S. Ghosh S. Genes Dev. 2004 18 2195 2224 3 Sillitoe K...
Articles
Biochem Soc Trans (2007) 35 (2): 281–283.
Published: 20 March 2007
...K. Ito PTM (post-translational modification) is the chemical modification of a protein after its translation. The well-studied PTM is phosphorylation, but, recently, PTMs have been re-focused by extensive studies on histone modifications and the discovery of the ubiquitin system. Histone...
Articles
Biochem Soc Trans (2006) 34 (6): 997–1001.
Published: 25 October 2006
... or microbial Toll-like receptor ligands and their effect depends on the expression of chemokine receptors on specific cell types. More and more evidence points towards a role for post-translational modifications in the fine-tuning of chemokine activity. Although both glycosylation and proteolytic processing...
Articles
Biochem Soc Trans (2006) 34 (1): 91–93.
Published: 20 January 2006
...@bioch.ox.ac.uk ). 14 9 2005 © 2006 The Biochemical Society 2006 c -type cytochrome cytochrome c maturation (Ccm) Escherichia coli haem post-translational modification c -Type cytochromes are characterized by covalent attachment of haem to protein through thioether bonds between...
Articles
Biochem Soc Trans (2006) 34 (1): 150–151.
Published: 20 January 2006
... is simply the two cysteines and the histidine of the haem-binding motif. 6 9 2005 © 2006 The Biochemical Society 2006 c -type cytochrome cytochrome c biogenesis System I cytochrome c maturation (Ccm) haem post-translational modification substrate specificity c -Type...
Articles
Biochem Soc Trans (2005) 33 (1): 145–146.
Published: 01 February 2005
... evidence for at least one additional system, for unanticipated diversity in the location of the systems and for the co-existence of multiple systems in some cells. 14 9 2004 © 2005 The Biochemical Society 2005 chloroplast c -type cytochrome haem post-translational modification...
Articles
Biochem Soc Trans (2004) 32 (6): 1087–1089.
Published: 26 October 2004
... to understanding NF-κB function in diseased tissues. Recent developments illustrating that post-translational modification of NF-κB subunits influences their nuclear role are discussed. These observations suggest that diagnosis and new therapies based on reprogramming NF-κB activity could be more efficient than...
Articles
Biochem Soc Trans (2004) 32 (2): 343–347.
Published: 01 April 2004
... Horsham Research Centre, U.K., 11–12 November 2003 14 October 2003 © 2004 Biochemical Society 2004 phosphatase phosphoinositide post-translational modification protein turnover tumour suppressor Abbreviations used: GFP, green fluorescent protein; MAGI, membrane...
Articles
Biochem Soc Trans (2002) 30 (4): 633–638.
Published: 01 August 2002
.... Introduction Cytochrome c maturation describes the process by which cells convert a linear polypeptide, the Key words cytochrorne c haern lyase, haern chaperone, haem transport, post-translational modification Abbreviation used CCHL, cytochrorne c haern lyase 'E-mail lthoeny@rnicro biol ethz ch 633...
Articles
Biochem Soc Trans (2001) 29 (2): 111–116.
Published: 01 May 2001
... 2000 © 2001 Biochemical Society 2001 crystal structure post-translational modification protein radical substrate interaction ARP, Arthromyces ramosus peroxidase LiP, lignin peroxidase MNP, methylnitrosopropane VA, veratryl alcohol Protein Engineering of Peroxidases...