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Keywords: post translational modification
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Biochem Soc Trans (2022) 50 (1): 387–401.
Published: 07 January 2022
...Jorge Ripoll-Rozada; Joshua W. C. Maxwell; Richard J. Payne; Pedro José Barbosa Pereira Tyrosine- O -sulfation is a common post-translational modification (PTM) of proteins following the cellular secretory pathway. First described in human fibrinogen, tyrosine- O -sulfation has long been associated...
Biochem Soc Trans (2021) 49 (6): 2495–2507.
Published: 02 December 2021
... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...
Biochem Soc Trans (2021) 49 (6): 2891–2901.
Published: 16 November 2021
... studies and enable therapeutic interventions in the O- GlcNAc field. O- GlcNAc is a monosaccharide post-translational modification (PTM) installed on thousands of nucleocytoplasmic and mitochondrial proteins at multiple serine or threonine residues in eukaryotic cells [ 1 ]. O- GlcNAc was first...
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
.... Eukaryotic DNA is packaged in the form of chromatin, where ∼150 base pairs of DNA is wrapped around an octameric core of histone proteins to form the nucleosome ( Figure 1a ) [ 1 ]. This elegant solution to the challenge of packaging DNA into the nucleus is further fine-tuned post-translational modification...
Biochem Soc Trans (2021) 49 (2): 867–880.
Published: 26 March 2021
...Yi Zhu; Gerald W. Hart O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity...
Biochem Soc Trans (2021) 49 (2): 855–866.
Published: 11 March 2021
... molecules require essential post-translational modifications (PTMs), including hydroxylation of proline and lysine residues, and subsequent attachment of glycan moieties (galactose and glucose) to specific hydroxylysine residues on procollagen alpha chains. The resulting galactosyl-hydroxylysine (Gal-Hyl...
Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
... be competitively inhibited by nitric oxide. In fact, nitric oxide has been shown capable of inhibiting PHD1–3 as well as a number of histone demethylases, although the biological role of these findings is unknown [ 37–39 ]. disease hydroxylation hypoxia nutrient sensing oxygenase post translational...
Biochem Soc Trans (2020) 48 (1): 95–101.
Published: 12 February 2020
... and the Biochemical Society under a transformative agreement with JISC. cell metabolism inorganic polyphosphates phosphate post translational modification signalling Arthur Kornberg and Igor Kulaev spent a large part of their careers working on inorganic polyphosphate (polyP). Convinced...
Biochem Soc Trans (2019) 47 (6): 1815–1831.
Published: 22 November 2019
... are subject of post-translational modifications such as phosphorylation, SUMOlyation, and acetylation. In this work, we summarize recent advances in the study of these immunophilins portraying them as scaffolding proteins capable to organize protein heterocomplexes, describing some of their antagonistic...