... phosphatidylethanolamine PI phosphatidylinositol PL phospholipid PM plasma membrane PS phosphatidylserine SM sphingomyelin flippase glycolipids lipid transfer phospholipids post translational modification scramblase References 1 Rothman , J.E...

... in various physiological processes and diseases, and analyze the accumulated lines of evidence supporting diverse molecular mechanisms associated with different PANX1 activation modalities. We focus on examining recent discoveries regarding PANX1 regulations by reversible post-translational modifications...

...Jorge Ripoll-Rozada; Joshua W. C. Maxwell; Richard J. Payne; Pedro José Barbosa Pereira Tyrosine- O -sulfation is a common post-translational modification (PTM) of proteins following the cellular secretory pathway. First described in human fibrinogen, tyrosine- O -sulfation has long been associated...

... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...

... deglycosylation glycosylation O -GlcNAc post translational modification protein engineering O- GlcNAc is a monosaccharide post-translational modification (PTM) installed on thousands of nucleocytoplasmic and mitochondrial proteins at multiple serine or threonine residues in eukaryotic cells [ 1...

... is wrapped around an octameric core of histone proteins to form the nucleosome ( Figure 1a ) [ 1 ]. This elegant solution to the challenge of packaging DNA into the nucleus is further fine-tuned post-translational modification of histone proteins (hPTMs) and modification of the DNA [ 2 , 3 ]. hPTMs...

...Yi Zhu; Gerald W. Hart O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity...

... molecules require essential post-translational modifications (PTMs), including hydroxylation of proline and lysine residues, and subsequent attachment of glycan moieties (galactose and glucose) to specific hydroxylysine residues on procollagen alpha chains. The resulting galactosyl-hydroxylysine (Gal-Hyl...

...-methylated residues. The requirement for oxygen, 2OG and iron, as well as the CO 2 and succinate by-products are omitted for simplicity in panels 2–4: see top panel for details. disease hydroxylation hypoxia nutrient sensing oxygenase post translational modification 2OG is a central...

... and the Biochemical Society under a transformative agreement with JISC. cell metabolism inorganic polyphosphates phosphate post translational modification signalling Arthur Kornberg and Igor Kulaev spent a large part of their careers working on inorganic polyphosphate (polyP). Convinced...

... are subject of post-translational modifications such as phosphorylation, SUMOlyation, and acetylation. In this work, we summarize recent advances in the study of these immunophilins portraying them as scaffolding proteins capable to organize protein heterocomplexes, describing some of their antagonistic...