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Keywords: post translational modification
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Biochem Soc Trans (2023) BST20221455.
Published: 28 September 2023
... phosphatidylethanolamine PI phosphatidylinositol PL phospholipid PM plasma membrane PS phosphatidylserine SM sphingomyelin flippase glycolipids lipid transfer phospholipids post translational modification scramblase References 1 Rothman , J.E...
Biochem Soc Trans (2023) 51 (4): 1687–1699.
Published: 25 August 2023
... in various physiological processes and diseases, and analyze the accumulated lines of evidence supporting diverse molecular mechanisms associated with different PANX1 activation modalities. We focus on examining recent discoveries regarding PANX1 regulations by reversible post-translational modifications...
Biochem Soc Trans (2022) 50 (1): 387–401.
Published: 07 January 2022
...Jorge Ripoll-Rozada; Joshua W. C. Maxwell; Richard J. Payne; Pedro José Barbosa Pereira Tyrosine- O -sulfation is a common post-translational modification (PTM) of proteins following the cellular secretory pathway. First described in human fibrinogen, tyrosine- O -sulfation has long been associated...
Biochem Soc Trans (2021) 49 (6): 2495–2507.
Published: 02 December 2021
... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...
Biochem Soc Trans (2021) 49 (6): 2891–2901.
Published: 16 November 2021
... deglycosylation glycosylation O -GlcNAc post translational modification protein engineering O- GlcNAc is a monosaccharide post-translational modification (PTM) installed on thousands of nucleocytoplasmic and mitochondrial proteins at multiple serine or threonine residues in eukaryotic cells [ 1...
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
... is wrapped around an octameric core of histone proteins to form the nucleosome ( Figure 1a ) [ 1 ]. This elegant solution to the challenge of packaging DNA into the nucleus is further fine-tuned post-translational modification of histone proteins (hPTMs) and modification of the DNA [ 2 , 3 ]. hPTMs...
Biochem Soc Trans (2021) 49 (2): 867–880.
Published: 26 March 2021
...Yi Zhu; Gerald W. Hart O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity...
Biochem Soc Trans (2021) 49 (2): 855–866.
Published: 11 March 2021
... molecules require essential post-translational modifications (PTMs), including hydroxylation of proline and lysine residues, and subsequent attachment of glycan moieties (galactose and glucose) to specific hydroxylysine residues on procollagen alpha chains. The resulting galactosyl-hydroxylysine (Gal-Hyl...
Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
...-methylated residues. The requirement for oxygen, 2OG and iron, as well as the CO 2 and succinate by-products are omitted for simplicity in panels 2–4: see top panel for details. disease hydroxylation hypoxia nutrient sensing oxygenase post translational modification 2OG is a central...
Biochem Soc Trans (2020) 48 (1): 95–101.
Published: 12 February 2020
... and the Biochemical Society under a transformative agreement with JISC. cell metabolism inorganic polyphosphates phosphate post translational modification signalling Arthur Kornberg and Igor Kulaev spent a large part of their careers working on inorganic polyphosphate (polyP). Convinced...