... Stein; Robbie Waugh The identification of genes underlying complex quantitative traits such as grain yield by means of conventional genetic analysis (positional cloning) requires the development of several large mapping populations. However, it is possible that phenotypically related, but more extreme...

...). The phenotype is controlled by an autosomal dominant allele designated RN − . The protein kinase AMP-activated γ3 subunit gene, PRKAG3 , which encodes the γ3 isoform of AMP-activated protein kinase (AMPK), was identified as the causative gene for this phenotype by a pure positional cloning approach...