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Keywords: polymerase
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Articles
Biochem Soc Trans (2017) 45 (2): 513–529.
Published: 13 April 2017
...Laura J. Bailey; Aidan J. Doherty PrimPol, (prim ase– pol ymerase), the most recently identified eukaryotic polymerase, has roles in both nuclear and mitochondrial DNA maintenance. PrimPol is capable of acting as a DNA polymerase, with the ability to extend primers and also bypass a variety...
Articles
Biochem Soc Trans (2011) 39 (1): 104–106.
Published: 19 January 2011
... domain consists of a catalytic primase/polymerase domain and an accessory helix-bundle domain. Structure-guided mutagenesis allowed us to identify amino acids which are important for template binding, dinucleotide formation and a step before primer extension. On the basis of functional and structural...
Articles
Biochem Soc Trans (2010) 38 (2): 381–383.
Published: 22 March 2010
... of remarkable enzymes has evolved, which includes translocases, polymerases/replicases, helicases, nucleases, topoisomerases, transposases, recombinases, repair enzymes and ribosomes. An understanding of how these enzymes function is essential if we are to have a clear view of the molecular biology of the cell...
Articles
Biochem Soc Trans (2009) 37 (3): 539–545.
Published: 20 May 2009
... uncomplicated. First, the broken ends are identified, the termini are then brought together (synapsis), processed by polymerase and nucleolytic activities (if required to restore complementarity) and, finally, the remaining nicks are ligated together to restore the integrity of the DNA duplex [ 1 , 2 ] ( Figure...