...Laura J. Bailey; Aidan J. Doherty PrimPol, (prim ase– pol ymerase), the most recently identified eukaryotic polymerase, has roles in both nuclear and mitochondrial DNA maintenance. PrimPol is capable of acting as a DNA polymerase, with the ability to extend primers and also bypass a variety...

... domain consists of a catalytic primase/polymerase domain and an accessory helix-bundle domain. Structure-guided mutagenesis allowed us to identify amino acids which are important for template binding, dinucleotide formation and a step before primer extension. On the basis of functional and structural...

... of remarkable enzymes has evolved, which includes translocases, polymerases/replicases, helicases, nucleases, topoisomerases, transposases, recombinases, repair enzymes and ribosomes. An understanding of how these enzymes function is essential if we are to have a clear view of the molecular biology of the cell...

... correspondence should be addressed (email ajd21@sussex.ac.uk ). 11 2 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 In addition to a wide diversity of extension activities, PolDoms possess other attributes that enable it to participate in atypical polymerase activities...