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Keywords: polyglutamine expansion
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Biochem Soc Trans (2010) 38 (2): 552–558.
Published: 22 March 2010
...Sarah L. Hands; Robert Mason; M. Umar Sajjad; Flaviano Giorgini; Andreas Wyttenbach HD (Huntington's disease) is caused by a polyQ (polyglutamine) expansion in the huntingtin protein, which leads to protein misfolding and aggregation of this protein. Abnormal copper accumulation in the HD brain...