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Keywords: polyamine biosynthesis
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Biochem Soc Trans (2007) 35 (2): 386–390.
Published: 20 March 2007
... membrane catecholamine receptors and AR, as well as c-Met. We found that this cross-talk modulated the expression of ODC and AdoMetDC, enzymes limiting polyamine biosynthesis, but not SSAT. This is in contrast with the antagonistic cross-talk between AR- and c-Met-mediated signalling which negatively...
Biochem Soc Trans (2007) 35 (2): 353–355.
Published: 20 March 2007
...F. Raul ODC (ornithine decarboxylase), a key enzyme of polyamine biosynthesis, is an inducible enzyme exhibiting high activity in tumour cells, suggesting ODC as a target for antineoplastic therapy. Among the inhibitors of polyamine-related enzymes, the ODC inactivator DFMO [2-(difluoromethyl...