... [ 6 – 8 ]. Owing to the established role of polynucleotide phosphorylase (PNPase) in 3′–5′ exoribonuclease activity on RNA and polyadenylation in prokaryotes, chloroplasts, and plant mitochondria [ 22 , 24 – 26 ], its human counterpart has been designated as the most suitable candidate to execute...

...Jessica G. Hardy; Chris J. Norbury Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3′UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how...

... remain to be understood [ 18 ]. 1 To whom correspondence should be addressed (email monika.gullerova@path.ox.ac.uk ). 8 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 budding yeast fission yeast polyadenylation sequencing untranslated region...

... a large region so that proper cleavage and polyadenylation is not blocked. This may be achieved through a paucity of potential U1-binding sites but this theory requires verification. From its key role in transcription initiation and maintenance of elongation through to its regulatory function in 3...

..., polyadenylation and nuclease activities in the human exosome and associated factors have been separated. 1 To whom correspondence should be addressed (email hopfner@lmb.uni-muenchen.de ). 10 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 archaeon exonuclease...

.... Katoh T. Ueda T. Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase J. Biol. Chem. 2005 280 19721 19727 8 Malecki M. Jedrzejczak R. Stepien P.P. Golik P. In vitro...

... is regulated through use of multiple promoters and alternative splicing and polyadenylation. The virus genome can be divided into an early and a late coding region. The late coding region contains the L1 and L2 genes. These encode the virus capsid proteins L1 and L2; protein expression is confined to the upper...