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Keywords: pluripotency
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Biochem Soc Trans (2024) 52 (2): 603–616.
Published: 04 April 2024
... complex in pluripotency and cell lineage primining and the approaches that have helped delineate its importance. Understanding these molecular mechanisms is crucial for unraveling the intricate processes governing embryonic stem cell biology and developmental transitions and may potentially apply to human...
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Biochem Soc Trans (2024) 52 (2): 639–650.
Published: 20 March 2024
...Qiyu Tian; Hoyoung Chung; Duancheng Wen Pluripotent stem cells (PSCs), comprising embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), offer immense potential for regenerative medicine due to their ability to differentiate into all cell types of the adult body. A critical aspect...
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Biochem Soc Trans (2021) 49 (6): 2941–2955.
Published: 02 December 2021
... pluripotency regenerative medicine Rho gtpases self-renewal stem cell therapy Mammalian Rho family GTPases are members of the Ras superfamily including over 20 gene products which can be further subdivided into six groups based on sequence identity, domain structure and function: RhoA subfamily...
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Biochem Soc Trans (2019) 47 (3): 875–885.
Published: 17 June 2019
... in pluripotent embryonic stem cells (ESCs) as they need to maintain self-renewal capabilities while retaining the potential to generate different cell types with diverse 5mC patterns. In this review, we discuss the multiple roles of TET proteins in mouse ESCs, and other vertebrate model systems...
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Biochem Soc Trans (2010) 38 (4): 1027–1032.
Published: 26 July 2010
...Jason Wray; Tuzer Kalkan; Austin G. Smith Pluripotency is defined as the capacity of individual cells to initiate all lineages of the mature organism in response to signals from the embryo or cell culture environment. A pluripotent cell has no predetermined programme; it is a blank slate...
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Biochem Soc Trans (2007) 35 (2): 225–228.
Published: 20 March 2007
...M.J. Welham; M.P. Storm; E. Kingham; H.K. Bone ES (embryonic stem) cell lines are derived from the epiblast of pre-implantation embryos and like the inner cell mass cells from which they are derived exhibit the remarkable property of pluripotency, namely the ability to differentiate into all cell...
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Biochem Soc Trans (2005) 33 (6): 1522–1525.
Published: 26 October 2005
...K. Takahashi; M. Murakami; S. Yamanaka Mouse ES (embryonic stem) cells maintain pluripotency with robust proliferation in vitro . ES cells share some similarities with cancer cells, such as anchorage-independent growth, loss of contact inhibition and tumour formation. After differentiation, ES...
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Biochem Soc Trans (2005) 33 (6): 1518–1521.
Published: 26 October 2005
...A. Yates; I. Chambers Intrinsic regulators of the pluripotency of mouse ES (embryonic stem) cells include the homeodomain proteins Oct4 and the recently identified Nanog. When overexpressed, Nanog displays the unique attribute of robustly sustaining ES cell self-renewal in the absence...