...Tomas L. Lindahl; Sofia Ramström; Niklas Boknäs; Lars Faxälv Platelet-derived polyphosphates (polyP), stored in dense granule and released upon platelet activation, have been claimed to enhance thrombin activation of coagulation factor XI (FXI) and to activate FXII directly. The latter claim...

...Nicola J. Mutch Platelets are small anuclear cells that play a central role in haemostasis. Platelets become activated in response to various stimuli triggering release of their granular contents into the surrounding milieu. One of these types of granules, termed dense granules, have been found...

...Melania Dovizio; Sara Alberti; Angela Sacco; Paloma Guillem-Llobat; Simone Schiavone; Thorsten J. Maier; Dieter Steinhilber; Paola Patrignani Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A 2 and prostaglandin...

...Sakthivel Vaiyapuri; Gagan D. Flora; Jonathan M. Gibbins Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and ischaemic stroke. Although platelets circulate in isolation, upon activation...

...Margaret R. Cunningham; Shaista P. Nisar; Stuart J. Mundell Platelets are critical for haemostasis, however inappropriate activation can lead to the development of arterial thrombosis, which can result in heart attack and stroke. ADP is a key platelet agonist that exerts its actions via stimulation...