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Keywords: plasticity
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Biochem Soc Trans (2020) 48 (6): 2891–2902.
Published: 18 December 2020
...Mélanie A. Eckersley-Maslin The concept of cellular plasticity is particularly apt in early embryonic development, where there is a tug-of-war between the stability and flexibility of cell identity. This balance is controlled in part through epigenetic mechanisms. Epigenetic plasticity dictates how...
Biochem Soc Trans (2020) 48 (4): 1609–1621.
Published: 14 August 2020
..., this normally tight control is often disrupted, leading to a wide scale hyper-plasticity of the epigenome and allowing stochastic gene activation and silencing, cell state transition, and potentiation of the effects of genetic lesions. Many of these epigenetic disruptions will confer a proliferative advantage...
Biochem Soc Trans (2014) 42 (5): 1316–1320.
Published: 18 September 2014
... 6 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Alzheimer’s disease amyloid astrocyte inflammation plasticity It is predicted that cases of dementia will increase to 135.5 million by 2050, with much of this increase occurring in developing countries...
Biochem Soc Trans (2014) 42 (3): 637–644.
Published: 22 May 2014
... as an example of plasticity of intrinsic progenitors and even differentiated cells. Of relevance, examples of plasticity and fate change characterize pathologies such as oesophageal metaplasia, whose possible cell origin is still debated, but has important implications as a pre-neoplastic event. Although much...
Biochem Soc Trans (2013) 41 (6): 1365–1382.
Published: 20 November 2013
... communication and local intracellular signalling to a degree that surpasses other cell types. The adaptive plastic properties of neurons, synapses and circuits have been classically studied by measurement of electrophysiological properties, ionic conductances and excitability. Over the last 15 years, the field...
Biochem Soc Trans (2011) 39 (6): 1639–1643.
Published: 21 November 2011
... to be determined during embryonic development, after which the ECs are committed to their fate. However, increasing evidence suggests that ECs retain various degrees of plasticity, and have the ability to express characteristics of alternative cell lineages. Therapeutic control of endothelial plasticity will allow...
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
.... This is achieved via the multiple stages of the endosomal system. AMPARs constitutively cycle through early endosomes and recycling endosomes to maintain synaptic receptor numbers. However, on induction of synaptic plasticity, subtle alterations are made to this cycle by the action of specific AMPAR-interacting...
Biochem Soc Trans (2007) 35 (1): 161–163.
Published: 22 January 2007
...P. Perry; B. Linke; W. Schmidt Post-embryonic development of the root system is highly plastic to environmental cues, compensating for the sessile lifestyle of plants. The fate of epidermal cells of Arabidopsis roots is particularly responsive to nutritional signals, leading to an increase...
Biochem Soc Trans (2005) 33 (6): 1350–1353.
Published: 26 October 2005
... and how this phosphorylation may control its function in the SV life cycle. 1 To whom correspondence should be addressed (email m.cousin@ed.ac.uk ). 13 6 2005 © 2005 The Biochemical Society 2005 exocytosis neuron phosphorylation plasticity synaptophysin tyrosine...
Biochem Soc Trans (2002) 30 (2): 222–225.
Published: 01 April 2002
... neurodegenerative disease plasticity microglia Biochemical Society Transactions (2002) Volume 30, part 2 Tissue plasminogen activator as a modulator of neuronal survival and function S. E. Tsirka' Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY I 1794-865 I...