...Manabu Kitamata; Takehiko Inaba; Shiro Suetsugu Lipid compositions of cells differ according to cell types and intracellular organelles. Phospholipids are major cell membrane lipids and have hydrophilic head groups and hydrophobic fatty acid tails. The cellular lipid membrane without any protein...

...Luis Alberto Luévano-Martínez; Anna L. Duncan Cardiolipin (CL) and its precursor phosphatidylglycerol (PG) are important anionic phospholipids widely distributed throughout all domains of life. They have key roles in several cellular processes by shaping membranes and modulating the activity...

... in terms of ATP hydrolysis, but the trajectory taken by the phospholipid substrate through the enzyme is a matter of current active research. There are currently three different models for this trajectory, all with support by mutation/activity measurements and analogies with known atomic structures. 12...

... © The Authors Journal compilation © 2014 Biochemical Society 2014 Candida albicans Cdc42 filamentous growth G-protein phospholipid Saccharomyces cerevisiae A number of fungi can grow by asexual reproduction via budding growth, in which a small bud is formed on a mother cell...

... should be addressed (email xiayang.qiu@pfizer.com ). 10 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cardiovascular disease (CVD) cholesteryl ester-transfer protein (CETP) neutral lipid phospholipid triacylglycerol (TAG) CETP (cholesteryl ester...

...@uthsc.edu ). 19 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 acyl-CoA cardiolipin (diphosphatidylglycerol) carnitine palmitoyltransferase phospholipid recombinant carnitine palmitoyltransferase II (recombinant CPT2) In addition to insulin, thyroid...

... Journal compilation © 2011 Biochemical Society 2011 Ca 2+ -ATPase hydrophobic matching lipid–protein interaction membrane protein phospholipid potassium channel Most biological membranes contain a complex mixture of lipid molecules differing in their polar regions and in their fatty...

... it is difficult to identify the bound molecules. In our studies, heavy-atom-labelled phospholipids and detergents have been used to unequivocally identify these binding sites at the surfaces of test membrane proteins, the reaction centres from Rhodobacter sphaeroides and Blastochloris viridis . The generality...

...William Dowhan; Mikhail Bogdanov To determine how the lipid environment affects membrane protein structure and function, strains of Escherichia coli were developed in which normal phospholipid composition can be altered or foreign lipids can be introduced. The properties of LacY (lactose permease...

... to by TRPC [TRP (transient receptor potential) canonical] channel subunits. Instead of being voltage-gated, these channels are chemically gated – importantly, by key phospholipid factors of vascular development and disease. This brief review focuses on the hypothesis that the transition to a modulated cell...

... several factors are known to stimulate the channel, understanding of its endogenous activators and functions is limited. This paper provides a brief and focused review of our latest findings that show that TRPC5 is a sensor of important signalling phospholipids, including lysophosphatidylcholine...

... affinity with LPS. The intermolecular disulphide bonding in the S3 dimer is indispensable for its LPS binding, disruption and consequent neutralization. Simultaneously, the specific interaction between the Sushi peptides and bacterial membrane phospholipids further explains the selective propensity...

... biosynthesis). Mutations to MET30 cause defects in both the MAM as a donor of PtdSer, and the mitochondria as an acceptor of PtdSer in the transport reaction. PtdSer transport to the locus of Psd2p is controlled by specific protein and lipid motifs. The C2 (Ca 2+ and phospholipid-binding sequence) domain...

...S. Yoshikawa Bovine heart cytochrome c oxidase is a large multi-component membrane protein containing several phospholipids. X-ray structures of this enzyme at high resolution, determined recently, show a trigonal planar structure of Cu B site in the O 2 reduction site, which could contribute...

... the role of specific lipid-binding sites for the structure and function of membrane proteins. cardiolipin lipid lipid–protein interaction membrane protein phospholipid X-ray structure Membrane protein structures account for less than 1% of the known high-resolution protein structures...

...G.M. Carman The yeast Saccharomyces cerevisiae has the ability to cope with a variety of stress conditions (e.g. zinc deficiency) by regulating the expression of enzyme activities including those involved with phospholipid synthesis. Zinc is an essential mineral required for the growth...

...P.J. Thornalley Glycation of proteins, nucleotides and basic phospholipids by glucose, glyoxal, methylglyoxal, 3-deoxyglucosone and other saccharide derivatives is potentially damaging to the proteome and mutagenic. It is now recognized that there is an enzymatic defence against glycation – a group...

...) made breast cancer cells more susceptible to lipid peroxidation. Studies have indicated that cancer cells may become enriched in CLA during growth in culture. This may make intracellular lipids more susceptible to ordinary Key words: cytotoxicity, lipid peroxidation, phospholipid. Abbreviations used...

..., a classical interrelation was observed between thermotropic behaviour and the fatty acid unsaturation of lipids. 1 To whom correspondence should be addressed (e-mail sanina@bio.dvgu.ru ) 20 6 2000 © 2000 Biochemical Society 2000 glycolipid phase transition phospholipid...

...A. Radunz; K. Alfermann; G. H. Schmid We analysed chloroplast lipids of Nicotiana tabacum var. John William's Broadleaf, cultivated under an increased Pco 2 of 700 p.p.m. Glycolipids and phospholipids remain constant under these conditions, whereas the carotenoid content undergoes a quantitative...

...S. N. Goncharova; N. M. Sanina; E. Y. Kostetsky By using the combined approaches of microcalorimetric analysis and polarizing microscopy, the crystal-liquid crystal-isotropic melt phase transition of major phospholipids (phosphatidylcholine and phosphatidylethanolamine) and glycolipids...

...H. Härtel; C. Benning To explore the role of digalactosyldiacylglycerol (DGDG) in plants the dgd1 mutant of Arabidopsis thaliana was grown in the presence and absence of inorganic phosphate. Phosphate deficiency in the dgd1 mutant causes a strong decrease in all phospholipids accompanied...