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Keywords: phosphoinositide 3-kinase
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Articles
Biochem Soc Trans (2020) 48 (4): 1397–1417.
Published: 17 July 2020
... for this article was enabled by the participation of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cytoskeleton nuclear functions p85 phosphoinositide 3-kinase receptor trafficking...
Articles
Biochem Soc Trans (2016) 44 (1): 240–252.
Published: 09 February 2016
...Matthew J. Eramo; Christina A. Mitchell The phosphoinositide 3-kinase (PI3K) generated lipid signals, PtdIns(3,4,5) P 3 and PtdIns(3,4) P 2 , are both required for the maximal activation of the serine/threonine kinase proto-oncogene Akt. The inositol polyphosphate 5-phosphatases (5-phosphatases...
Articles
Biochem Soc Trans (2016) 44 (1): 273–278.
Published: 09 February 2016
... number ETM-433] and the Medical Research Council [grant number G0801865/2]. MKRN1 makorin ring finger protein 1 mTOR mammalian target of rapamycin NEDD4 neural precursor cell expressed, developmentally down-regulated 4 PI3K phosphoinositide 3-kinase PIP 3...
Articles
Biochem Soc Trans (2004) 32 (5): 789–791.
Published: 26 October 2004
...B.J. Hebeis; E. Vigorito; M. Turner PI3K (phosphoinositide 3-kinase) I A family members contain a regulatory subunit and a catalytic subunit. The p110δ catalytic subunit is expressed predominantly in haematopoietic cells. There, among other functions, it regulates antigen receptor-mediated...
Articles
Biochem Soc Trans (2004) 32 (3): 456–460.
Published: 01 June 2004
... process is mediated via phosphoinositide 3-kinase and NF-κB (nuclear factor-κB) activation. In the present study, we show that, in contrast with GM-CSF (granulocyte/macrophage colony-stimulating factor), the delayed addition (i.e. at 6 h) of TNFα increases its survival effect despite substantial loss...
Articles
Biochem Soc Trans (2004) 32 (2): 360–361.
Published: 01 April 2004
... cyclins. Activation of cyclin E/cdk2 (cyclin-dependent kinase 2) at the end of G 1 is then required to trigger DNA synthesis (S phase entry). Among the early signals induced by mitogens, activation of PI3K (phosphoinositide 3-kinase) appears essential to induce cell cycle entry, as it regulates cell...
Articles
Biochem Soc Trans (2004) 32 (2): 326–329.
Published: 01 April 2004
... provides a novel shuttling mechanism that allows Btk to regulate the production of the substrate required by both its upstream activator phosphoinositide 3-kinase and its downstream target phospholipase Cγ2. 1 e-mail ccarpent@bidmc.harvard.edu PI-3 Kinase in Signalling and Disease, a Biochemical...
Articles
Biochem Soc Trans (2004) 32 (2): 348–349.
Published: 01 April 2004
...A.C. Schmid; R. Woscholski Inositols and their phosphorylated derivatives, phosphoinositides, play an important role in diverse cellular functions. They have been recognized as second messengers and are accurately controlled by phosphatases and kinases, such as phosphoinositide 3-kinase...
Articles
Biochem Soc Trans (2004) 32 (2): 330–331.
Published: 01 April 2004
...L.C. Foukas; P.R. Shepherd Class I phosphoinositide 3-kinases were originally characterized as lipid kinases, although more than 10 years ago they were also found to phosphorylate protein serine residues. However, while there is a vast amount of data on the function of this lipid kinase activity...
Articles
Biochem Soc Trans (2004) 32 (2): 355–359.
Published: 01 April 2004
... PTEN (phosphatase and tensin homologue deleted on chromosome 10) correlates with increased invasive cell growth due to the resulting chronic activation of the PI 3-kinase (phosphoinositide 3-kinase) pathway. Induced activation of PI 3-kinase either by inhibiting PTEN expression or by using p110...
Articles
Biochem Soc Trans (2003) 31 (1): 292–297.
Published: 01 February 2003
...K.U. Birkenkamp; P.J. Coffer Recently, the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors has been identified as direct targets of phosphoinositide 3-kinase-mediated signal transduction. The AFX (acute-lymphocytic-leukaemia-1 fused gene from chromosome X), FKHR (Forkhead...
Articles
Biochem Soc Trans (2002) 30 (2): 312–317.
Published: 01 April 2002
... receptor phosphoinositide 3-kinase Biochemical Society Transactions (2002) Volume 30, part 2 ~ ~~ Short-term regulation of insulin gene transcription B. Leibiger , T. Moede, S. Uhles, P.-0. Berggren and 1. B. Leibiger The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine...
Articles
Biochem Soc Trans (2001) 29 (4): 377–384.
Published: 01 August 2001
... correspondence should be addressed (e-mail mlemmon@mail.med.upenn.edu ) 16 3 2001 © 2001 Biochemical Society 2001 PH domains phosphoinositide-binding sites phosphoinositide 3-kinase X-ray crystallography Btk, Bruton's tyrosine kinase DAPPI, d ual a daptor for p hosphotyrosine...
Articles
Biochem Soc Trans (2001) 29 (4): 513–525.
Published: 01 August 2001
...-related receptor CR, cysteine-rich JM, juxtamembrane CT, C-terminal IRS, IR substrate SH, Src homology PI, 3-kinase phosphoinositide 3-kinase PKB, protein kinase B ERK, extracellular-signal-regulated kinase MAPK, mitogen-activated protein kinase PH, pleckstrin homology APS, adaptor protein...