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Keywords: phosphoinositide
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Articles
Biochem Soc Trans (2021) 49 (2): 893–901.
Published: 05 March 2021
... phosphoinositide lipids at the 3′ position of their inositol rings, and in mammals they are divided into three classes. The role of the class III PI3K Vps34 is well-established, but recent evidence suggests the physiological significance of class II PI3K isoforms in vesicular trafficking. This review focuses...
Articles
Biochem Soc Trans (2016) 44 (2): 425–430.
Published: 11 April 2016
... between lysosomes and peroxisomes, contain phosphorylated derivatives of phosphatidylinositol known as phosphoinositides. In this mini-review we discuss the involvement and functions of phosphoinositides in membrane contact sites. 1 To whom correspondence should be addressed (email stenmark...
Articles
Biochem Soc Trans (2016) 44 (1): 228–233.
Published: 09 February 2016
...@pitt.edu . 2 11 2015 © 2016 Authors; published by Portland Press Limited 2016 lipid raft microdomain nanoscopy phosphoinositide The plasma membrane (PM) of any eukaryotic cell is a frenetic hub of activity. It mediates a ceaseless exchange of minerals, nutrients and waste...
Articles
Biochem Soc Trans (2016) 44 (1): 299–306.
Published: 09 February 2016
...Nullin Divecha Phosphoinositides are a family of phospholipid messenger molecules that control various aspects of cell biology in part by interacting with and regulating downstream protein partners. Importantly, phosphoinositides are present in the nucleus. They form part of the nuclear envelope...
Articles
Biochem Soc Trans (2014) 42 (5): 1383–1388.
Published: 18 September 2014
... as molecules. In the present paper, we discuss our recent work with Sec14-like PITPs and describe how PITPs integrate diverse territories of the lipid metabolome with phosphoinositide signalling. 1 To whom correspondence should be addressed (email vytas@tamhsc.edu ) . 9 7 2014 ©...
Articles
Biochem Soc Trans (2014) 42 (5): 1389–1395.
Published: 18 September 2014
... complex 1 (mTORC1) phosphatidylinositol 3-phosphate (PI3P) phosphoinositide Unc-51-like kinase (ULK) complex vacuolar protein sorting 34 (VPS34) complex I Autophagy is conserved in all eukaryotic cells from yeast to humans and depends on a common set of genes first identified and characterized...
Articles
Biochem Soc Trans (2014) 42 (5): 1335–1342.
Published: 18 September 2014
... the molecular mechanisms of nuclear envelope assembly in echinoderm and mammalian cells. Our findings have led to the demonstration of a direct role for phosphoinositides and their derivatives in nuclear membrane formation. We have shown that phosphoinositides and their derivatives, as well as acting as second...
Articles
Biochem Soc Trans (2012) 40 (1): 257–261.
Published: 19 January 2012
...Deborah L. Grainger; Christodoulos Tavelis; Alexander J. Ryan; Katherine A. Hinchliffe Of the seven phosphoinositides, PtdIns5 P remains the most enigmatic. However, recent research has begun to elucidate its physiological functions. It is now clear that PtdIns5 P is found in several distinct...
Articles
Biochem Soc Trans (2012) 40 (1): 205–209.
Published: 19 January 2012
.... The central elements of this regulation are specific phosphoinositide 4-kinases and the phosphoinositide phosphatase Sac1. Growth-dependent translocation of Sac1 between the ER and Golgi modulates the levels of PtdIns4 P and anterograde traffic at the Golgi. In yeast, this mechanism is largely dependent...
Articles
Biochem Soc Trans (2012) 40 (1): 101–107.
Published: 19 January 2012
...Daniela Corda; Pasquale Zizza; Alessia Varone; Karol S. Bruzik; Stefania Mariggiò Interest in the glycerophosphoinositols has been increasing recently, on the basis of their biological activities. The cellular metabolism of these water-soluble bioactive phosphoinositide metabolites has been...
Articles
Biochem Soc Trans (2011) 39 (4): 839–850.
Published: 20 July 2011
...Peter J. Cullen From the pioneering work of Mabel and Lowell Hokin in the 1950s, the biology of this specific isomer of hexahydroxycyclohexane and its phosphorylated derivatives, in the form of inositol phosphates and phosphoinositides, has expanded to fill virtually every corner of cell biology...
Articles
Biochem Soc Trans (2010) 38 (2): 705–709.
Published: 22 March 2010
...Noa Wigoda; Xiaohong Ma; Nava Moran Phosphoinositides play an important role in both abiotic and biotic signalling in plants. The signalling cascade may include the production of second messengers by hydrolysis of PtdIns(4,5) P 2 . However, increasingly, PtdIns(4,5) P 2 itself is shown to mediate...
Articles
Biochem Soc Trans (2009) 37 (5): 1099–1103.
Published: 21 September 2009
... findings indicate that inositol and inositol-containing molecules, including phosphoinositides and inositol phosphates, have signalling and regulatory roles in many cellular processes. This suggests that depleting inositol may lead to perturbation of a wide range of cellular functions, at least some...
Articles
Biochem Soc Trans (2009) 37 (5): 1139–1143.
Published: 21 September 2009
...Elena Di Daniel; James N. Kew; Peter R. Maycox Phosphoinositide signalling regulates a series of important neuronal processes that are thought to be altered in mood disorders. Furthermore, mood-stabilizing drugs inhibit key enzymes that regulate phosphoinositide production and alter neuronal growth...
Articles
Biochem Soc Trans (2007) 35 (4): 742–745.
Published: 20 July 2007
...) phosphoinositide Alanine substitution of a particular amino acid deletes the side chain beyond the β-carbon atom. The effect on receptor function depends on the interactions made by the deleted side chain. The extended ternary complex model of GPCR activation provides a suitable predictive framework...
Articles
Biochem Soc Trans (2007) 35 (1): 105–108.
Published: 22 January 2007
... phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP 2 ) transient receptor potential channel (TRP channel) transient receptor potential melastatin 4 (TRPM4) voltage-dependence Phosphoinositides are ubiquitously used signalling molecules in eukaryotic cells, and modulate a plethora of soluble...
Articles
Biochem Soc Trans (2006) 34 (5): 647–662.
Published: 25 October 2006
...P.T. Hawkins; K.E. Anderson; K. Davidson; L.R. Stephens It is now accepted that activation of Class I PI3Ks (phosphoinositide 3-kinases) is one of the most important signal transduction pathways used by cell-surface receptors to control intracellular events. The receptors which access this pathway...
Articles
Biochem Soc Trans (2005) 33 (6): 1276–1278.
Published: 26 October 2005
...) clathrin-independent endocytosis endocytosis Golgi membrane traffic phosphoinositide Future studies will focus on the function of PIP 2 in this endocytic pathway, which proteins are recruited to the endosomal membranes by PIP 2 and by what mechanism PIP 2 is lost from the endosome. Another...
Articles
Biochem Soc Trans (2005) 33 (6): 1285–1289.
Published: 26 October 2005
...V. Haucke Endocytosis of transmembrane receptors largely occurs via clathrin-coated vesicles that bud from the plasma membrane and deliver their cargo to the endosomal system for recycling or degradation. PIs (phosphoinositides) control the timing and localization of endocytic membrane trafficking...
Articles
Biochem Soc Trans (2004) 32 (5): 707–711.
Published: 26 October 2004
...M.A. Lemmon PH domains (pleckstrin homology domains) are the 11th most common domain in the human genome and are best known for their ability to target cellular membranes by binding specifically to phosphoinositides. Recent studies in yeast have shown that, in fact, this is a property of only...
Articles
Biochem Soc Trans (2004) 32 (6): 893–898.
Published: 26 October 2004
...P.J. Parker There are now known to exist seven phosphoinositides all derived through various metabolic routes from the parent lipid phosphatidylinositol. With one additional metabolite, diacylglycerol, these represent a rich resource of bioactive lipids responsible for recruiting protein effectors...
Articles
Biochem Soc Trans (2004) 32 (2): 343–347.
Published: 01 April 2004
... Horsham Research Centre, U.K., 11–12 November 2003 14 October 2003 © 2004 Biochemical Society 2004 phosphatase phosphoinositide post-translational modification protein turnover tumour suppressor Abbreviations used: GFP, green fluorescent protein; MAGI, membrane...
Articles
Biochem Soc Trans (2003) 31 (1): 270–274.
Published: 01 February 2003
...K. Okkenhaug; B. Vanhaesebroeck Phosphoinositide 3-kinases (PI3Ks) are important signalling enzymes in most cell types. Recent gene targeting studies have shed light on the importance of this family of lipid kinases in the immune system, and the complex mechanisms by which these kinases...
Articles
Biochem Soc Trans (2001) 29 (6): 846–851.
Published: 01 November 2001
.... Its physiological substrates, however, are primarily 3-phosphorylated inositol phospholipids, which are products of phosphoinositide 3-kinases. PTEN thus antagonizes PI 3-kinase-dependent signalling pathways, which explains to a large extent its tumour suppressor status. We have examined the kinetic...
Articles
Biochem Soc Trans (2001) 29 (6): 860–863.
Published: 01 November 2001
... correspondence should be addressed (e-mail parkerp@icrf.icnet.uk ). 13 7 2001 © 2001 Biochemical Society 2001 autophosphorylation input/signal permissive phosphoinositide signal transduction AGC, cAMP-dependent protein kinase/protein kinase G/protein kinase C extended family DAG...
Articles
Biochem Soc Trans (2001) 29 (4): 472–475.
Published: 01 August 2001
... endocytosis endosome phosphoinositide signal transduction AMSH, associated molecule with the SH3 domain of STAM EGF, epidermal growth factor GM-CSF, granulocyte/macrophage colony-stimulating factor HGF, hepatocyte growth factor Hrs, HGF-regulated tyrosine kinase substrate ITAM, immunotyrosine...