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Keywords: phosphatidylinositol
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Articles
Biochem Soc Trans (2020) 48 (1): 187–197.
Published: 17 February 2020
... ( dematteis@tigem.it ) 6 11 2019 20 1 2020 24 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 endoplasmic reticulum golgi apparatus membrane contact sites phosphatidylinositol Membrane contact sites (MCSs...
Articles
Biochem Soc Trans (2019) 47 (5): 1291–1305.
Published: 28 October 2019
... difficulties, the picture is still far from clear. Figure 1. Phosphoinositide structures, metabolism and interactions with effectors. ( A ) A typical phosphoinositide (PIPn) structure is represented by C38:4 PI3P (sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate). The fatty acids acylated...
Articles
Biochem Soc Trans (2019) 47 (4): 985–995.
Published: 05 July 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cadherin caveolae phosphatidylinositol plasma membrane Physical connections between cells influence the morphogenesis, homeostasis and physiology of diverse tissues. These connections range from the cell–cell junctions...
Articles
Biochem Soc Trans (2016) 44 (1): 286–292.
Published: 09 February 2016
...Shamshad Cockcroft; Kathryn Garner; Shweta Yadav; Evelyn Gomez-Espinoza; Padinjat Raghu Phosphatidylinositol (PI) is the precursor lipid for the synthesis of PI 4,5-bisphosphate [PI(4,5) P 2 ] at the plasma membrane (PM) and is sequentially phosphorylated by the lipid kinases, PI 4-kinase...
Articles
Biochem Soc Trans (2014) 42 (5): 1383–1388.
Published: 18 September 2014
...Ashutosh Tripathi; Aaron H. Nile; Vytas A. Bankaitis The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatidylcholine (PtdCho)-transfer proteins are poorly characterized, even though these proteins are conserved throughout the eukaryotic kingdom. Much...
Articles
Biochem Soc Trans (2014) 42 (5): 1343–1348.
Published: 18 September 2014
... mimetic phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol phosphoinositide 3-kinase (PI3K) Research into phosphoinositide-dependent signalling has been around for many decades and has now become a staple ingredient of many important mechanisms governing...
Articles
Biochem Soc Trans (2012) 40 (2): 451–456.
Published: 21 March 2012
...Shamshad Cockcroft; Kathryn Garner PITPs (phosphatidylinositol transfer proteins) are characterized by the presence of the PITP domain whose biochemical properties of binding and transferring PI (phosphatidylinositol) are well studied. Despite their wide-spread expression in both unicellular...
Articles
Biochem Soc Trans (2009) 37 (5): 1115–1120.
Published: 21 September 2009
...-stabilizing effects of VPA and LiCl in bipolar disorder. 1 To whom correspondence should be addressed (email M.Schweizer@hw.ac.uk ). 29 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 bipolar disorder lithium phosphatidylinositol phosphoribosyl...
Articles
Biochem Soc Trans (2007) 35 (2): 245–249.
Published: 20 March 2007
... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...
Articles
Biochem Soc Trans (2006) 34 (3): 363–366.
Published: 22 May 2006
... CPT diphosphate-choline transferase CtBP C-terminal binding protein DAG diacylglycerol ER endoplasmic reticulum LPA lysophosphatidic acid PA phosphatidic acid PAP PA phosphohydrolase PC phosphatidylcholine PI phosphatidylinositol PI4K...
Articles
Biochem Soc Trans (2005) 33 (5): 1150–1153.
Published: 26 October 2005
... and metabolism of S. cerevisiae . Depletion of zinc from the growth medium of wild-type cells results in alterations in phospholipid composition including an increase in PI (phosphatidylinositol) and a decrease in phosphatidylethanolamine. These changes can be attributed to an increase in PIS1 -encoded PI...
Articles
Biochem Soc Trans (2004) 32 (6): 1057–1059.
Published: 26 October 2004
...A.D. Postle; H. Dombrowsky; H. Clarke; C.J. Pynn; G. Koster; A.N. Hunt Mammalian cell PtdIns (phosphatidylinositol) in vivo is enriched in the sn -1-stearoyl 2-arachidonoyl species, the physiological precursor of phosphatidylinositol 4,5-bisphosphate. Mechanisms regulating this specificity...
Articles
Biochem Soc Trans (2004) 32 (6): 1063–1065.
Published: 26 October 2004
...A.N. Hunt; J.G. Alb; G. Koster; A.D. Postle; V.A. Bankaitis The mammalian phospholipid exchange protein PITPα (phosphatidylinositol transfer protein alpha), found in both extranuclear and endonuclear compartments, is thought in part to facilitate nuclear import of the PtdIns (phosphatidylinositol...
Articles
Biochem Soc Trans (2004) 32 (2): 326–329.
Published: 01 April 2004
... associated with PIP5Ks (phosphatidylinositol 4-phosphate 5-kinases), the enzymes that synthesize PtdIns(4,5) P 2 . Btk functions as a shuttle to bring PIP5K to the plasma membrane as a means of stimulating PtdIns(4,5) P 2 synthesis. The Btk–PIP5K complex appears to localize to lipid rafts. This complex...