... the different stages of phagocytosis, the lipidome however, remained lesser explored, until the past few years. In this review, we summarize recent efforts towards mapping the physiological roles and functions of three lipid classes, the phosphatidylinositols, cholesterol and sphingolipids during the various...

... ( dematteis@tigem.it ) 6 11 2019 20 1 2020 24 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 endoplasmic reticulum golgi apparatus membrane contact sites phosphatidylinositol Membrane contact sites (MCSs...

... the Creative Commons Attribution License 4.0 (CC BY) . lipid metabolism lipid-binding domains membranes phosphatidylinositol polyunsaturated fatty acids signalling Phosphoinositides (PIPn) are a family of eight phospholipids (PI, PI3P, PI4P, PI5P, PI(4,5)P 2 , PI(3,4)P 2 , PI(3,5)P 2 , PI...

... phosphatidylinositol plasma membrane Physical connections between cells influence the morphogenesis, homeostasis and physiology of diverse tissues. These connections range from the cell–cell junctions that couple epithelial and endothelial cells into tissue barriers to the synaptic connections of the nervous...

...Shamshad Cockcroft; Kathryn Garner; Shweta Yadav; Evelyn Gomez-Espinoza; Padinjat Raghu Phosphatidylinositol (PI) is the precursor lipid for the synthesis of PI 4,5-bisphosphate [PI(4,5) P 2 ] at the plasma membrane (PM) and is sequentially phosphorylated by the lipid kinases, PI 4-kinase...

...Ashutosh Tripathi; Aaron H. Nile; Vytas A. Bankaitis The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatidylcholine (PtdCho)-transfer proteins are poorly characterized, even though these proteins are conserved throughout the eukaryotic kingdom. Much...

... lipid-dependent signalling without the need to correlate it to lipid metabolism. Figure 1 Timeline of chemical intervention tools for phosphoinositide 3-kinases and phosphatases The upper part shows the different headgroups of phosphatidylinositol placed along the timeline with respect...

...Shamshad Cockcroft; Kathryn Garner PITPs (phosphatidylinositol transfer proteins) are characterized by the presence of the PITP domain whose biochemical properties of binding and transferring PI (phosphatidylinositol) are well studied. Despite their wide-spread expression in both unicellular...

.... Microbiol. 2007 63 1248 1258 44 Cameroni E. De Virgilio C. Deloche O. Phosphatidylinositol 4-phosphate is required for translation initiation in Saccharomyces cerevisiae J. Biol. Chem. 2006 281 38139 38149 45 Fruman D.A. Meyers R.E. Cantley L.C...

... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...

... phosphohydrolase PC phosphatidylcholine PI phosphatidylinositol PI4K phosphoinositide 4-kinase PITP PI-transfer protein PKD protein kinase D PLD phospholipase D PM plasma membrane RNAi RNA interference SM sphingomyelin TGN trans -Golgi network...

... and metabolism of S. cerevisiae . Depletion of zinc from the growth medium of wild-type cells results in alterations in phospholipid composition including an increase in PI (phosphatidylinositol) and a decrease in phosphatidylethanolamine. These changes can be attributed to an increase in PIS1 -encoded PI...

...A.D. Postle; H. Dombrowsky; H. Clarke; C.J. Pynn; G. Koster; A.N. Hunt Mammalian cell PtdIns (phosphatidylinositol) in vivo is enriched in the sn -1-stearoyl 2-arachidonoyl species, the physiological precursor of phosphatidylinositol 4,5-bisphosphate. Mechanisms regulating this specificity...

...A.N. Hunt; J.G. Alb; G. Koster; A.D. Postle; V.A. Bankaitis The mammalian phospholipid exchange protein PITPα (phosphatidylinositol transfer protein alpha), found in both extranuclear and endonuclear compartments, is thought in part to facilitate nuclear import of the PtdIns (phosphatidylinositol...

... associated with PIP5Ks (phosphatidylinositol 4-phosphate 5-kinases), the enzymes that synthesize PtdIns(4,5) P 2 . Btk functions as a shuttle to bring PIP5K to the plasma membrane as a means of stimulating PtdIns(4,5) P 2 synthesis. The Btk–PIP5K complex appears to localize to lipid rafts. This complex...