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Keywords: phase separation
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Articles
Biochem Soc Trans (2021) 49 (6): 2591–2600.
Published: 25 November 2021
... by which cells can generate subcellular microenvironments with specialized gene expression profiles. Particularly intriguing are recent findings that phase separation plays a role in certain RNA localization pathways. The burgeoning field of phase separation has revolutionized how we view cellular...
Articles
Biochem Soc Trans (2021) 49 (6): 2871–2878.
Published: 23 November 2021
... of the nuclear compartments are formed through a liquid–liquid phase separation process. This new paradigm early penetrated the stem cells field since many key players of the pluripotency circuitry seem to phase-separate. Overall, the formation of liquid compartments may modulate the kinetics of biochemical...
Articles
Biochem Soc Trans (2021) 49 (4): 1675–1684.
Published: 20 July 2021
... 25 6 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 chromatin architecture computer simulations machine learning phase separation polymer physics SBS model In the human genome, only a fraction of ∼5–15% of the DNA...
Articles
Biochem Soc Trans (2020) 48 (5): 2151–2158.
Published: 28 September 2020
...–liquid phase separation (but see [ 2 ]), is increasingly appreciated as a biophysical mechanism underlying cellular organization and regulation, alongside its well-appreciated role in disease [ 1 , 3 , 4 ]. Hence, we distinguish ‘functional' protein condensates, such as the nuclear pore [ 5 , 6...
Articles
Biochem Soc Trans (2020) 48 (5): 2003–2014.
Published: 08 September 2020
.... autophagy in vitro reconstitution phase separation Atg8 is a ubiquitin-like protein that is conjugated with a phospholipid, phosphatidylethanolamine (PE), via reactions similar to ubiquitination [ 85 ]. Atg8–PE is tightly bound to the IM throughout the autophagosome formation process and has...
Articles
Biochem Soc Trans (2020) 48 (5): 1967–1978.
Published: 08 September 2020
... be investigated by in situ techniques such as cytological visualization, Cleavage Under Targets and Release Using Nuclease (CUT&RUN) [ 40 ] and Hi-C [ 41 ], in the control and RNase A treated cells. architectural RNA chromatin compaction heterochromatin nuclear bodies phase separation...