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Keywords: pharmacology
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Biochem Soc Trans (2020) 48 (2): 559–567.
Published: 02 April 2020
...@sheffield.ac.uk ) 20 12 2019 3 3 2020 9 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 drug effects pharmacology repurposing Originally published over 70 years ago, the use of anti-folates as a treatment...
Biochem Soc Trans (2016) 44 (3): 824–830.
Published: 09 June 2016
... transporter ATPase multidrug pump pharmacology Multidrug resistance (MDR) can be defined as the ability of cells or organisms to resist the cytotoxic effects of a diverse range of chemical structures, often with different intracellular targets. MDR is observed across the spectrum of infectious...
Biochem Soc Trans (2016) 44 (1): 191–196.
Published: 09 February 2016
... inositol phosphate cell-signalling drug pharmacology structure The inositol pyrophosphates (PP-IPs; Figure 1 ) comprise a unique class of cell-signalling molecules characterized by their functionally-significant and highly ‘energetic’ diphosphate groups [ 1 , 2 ]. As many as seven (‘InsP 7...
Biochem Soc Trans (2015) 43 (4): 593–594.
Published: 03 August 2015
... and clinical applications. 1 Correspondence may be addressed to either of these authors (email mcapanella@rvc.ac.uk or federico.turkheimer@kcl.ac.uk ) . 1 4 2015 © 2015 Authors; published by Portland Press Limited 2015 diagnostici imaging metabolism mitochondria pharmacology...
Biochem Soc Trans (2015) 43 (3): 495–501.
Published: 01 June 2015
... of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals...
Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...
Biochem Soc Trans (2010) 38 (4): 1051–1057.
Published: 26 July 2010
... may well be totally different, as they are more and more envisioned as opening new routes for pharmacological research. Pluripotent stem cells indeed possess the main attributes that make them theoretically fully equipped for the development of cell-based assays in the fields of drug discovery...