... effects are likely associated with the folate pathway. This insight into the mechanism-of-action of MTX opens the possibility for repurposing this low cost, safe and effective drug for the treatment of other JAK/STAT pathway-associated diseases. drug effects pharmacology repurposing In addition...

... transporter ATPase multidrug pump pharmacology Multidrug resistance (MDR) can be defined as the ability of cells or organisms to resist the cytotoxic effects of a diverse range of chemical structures, often with different intracellular targets. MDR is observed across the spectrum of infectious...

... inositol phosphate cell-signalling drug pharmacology structure The inositol pyrophosphates (PP-IPs; Figure 1 ) comprise a unique class of cell-signalling molecules characterized by their functionally-significant and highly ‘energetic’ diphosphate groups [ 1 , 2 ]. As many as seven (‘InsP 7...

... and clinical applications. 1 Correspondence may be addressed to either of these authors (email mcapanella@rvc.ac.uk or federico.turkheimer@kcl.ac.uk ) . 1 4 2015 © 2015 Authors; published by Portland Press Limited 2015 diagnostici imaging metabolism mitochondria pharmacology...

... of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals...

...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...

... may well be totally different, as they are more and more envisioned as opening new routes for pharmacological research. Pluripotent stem cells indeed possess the main attributes that make them theoretically fully equipped for the development of cell-based assays in the fields of drug discovery...