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Keywords: pharmacology
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Articles
Biochem Soc Trans (2020) 48 (2): 559–567.
Published: 02 April 2020
...@sheffield.ac.uk ) 20 12 2019 3 3 2020 9 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 drug effects pharmacology repurposing Originally published over 70 years ago, the use of anti-folates as a treatment...
Articles
Biochem Soc Trans (2016) 44 (3): 824–830.
Published: 09 June 2016
... pharmacology is a crucial area of current research; given the polyspecificity of the transporter it is inevitable that some polymorphisms will impact on the pharmacokinetics of particular drugs. Perhaps the most well documented of these is the rs2231142 polymorphism, Q141K. This polymorphism (which...
Articles
Biochem Soc Trans (2016) 44 (1): 191–196.
Published: 09 February 2016
... inositol phosphate cell-signalling drug pharmacology structure The inositol pyrophosphates (PP-IPs; Figure 1 ) comprise a unique class of cell-signalling molecules characterized by their functionally-significant and highly ‘energetic’ diphosphate groups [ 1 , 2 ]. As many as seven (‘InsP 7...
Articles
Biochem Soc Trans (2015) 43 (4): 593–594.
Published: 03 August 2015
... and clinical applications. 1 Correspondence may be addressed to either of these authors (email mcapanella@rvc.ac.uk or federico.turkheimer@kcl.ac.uk ) . 1 4 2015 © 2015 Authors; published by Portland Press Limited 2015 diagnostici imaging metabolism mitochondria pharmacology...
Articles
Biochem Soc Trans (2015) 43 (3): 495–501.
Published: 01 June 2015
... of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals...
Articles
Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology The Biochemical Society/Monash University Focused Meeting ‘G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms’ held in Prato in September 2012 has proved particularly timely. During...
Articles
Biochem Soc Trans (2010) 38 (4): 1051–1057.
Published: 26 July 2010
... may well be totally different, as they are more and more envisioned as opening new routes for pharmacological research. Pluripotent stem cells indeed possess the main attributes that make them theoretically fully equipped for the development of cell-based assays in the fields of drug discovery...