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Keywords: pharmacological chaperones
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Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
... or reverse SOD1 aggregation within neuron-like cells without subunit tethering [ 83 ]. Figure 3. Pharmacological chaperones targeting SOD1 Cys111. Structures of each chaperone before and after covalent binding to SOD1 sulphydryls. Ebselen is a small molecule organoselenium with antioxidant...