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Keywords: passenger strand
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Biochem Soc Trans (2014) 42 (4): 1135–1140.
Published: 11 August 2014
... gets degraded (the passenger strand or miR*). Thermodynamic features of the duplex appear to play an important role in this decision; the strand with the weakest binding at its 5′-end is more likely to become the guide strand. Other key characteristics of human miRNA guide strands are a U-bias at the 5...