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Biochem Soc Trans (2022) 50 (6): 1773–1783.
Published: 09 December 2022
..., but rather mitochondria are engulfed directly by lysosomes, mediating mitochondrial secretion. As FNZ results in parkinsonism, we propose that excessive mitolysosome exocytosis is the cause. Correspondence: Xingguo Liu ( email@example.com ) 27 9 2022 14 11 2022 25 11 2022 ©...
Biochem Soc Trans (2016) 44 (2): 659–661.
Published: 11 April 2016
... Parkinsonism PKRN, POLG Mitochondrial repair Dopamine metabolism damaging Motor neurons ALS TDP43, MATR3 RNA metabolism Protein synthesis at distant sites Motor neurons/ pyramidal neurons FTD/ALS VCP Ubiquitin proteasome Protein degradation throughout large cell Pyramidal neurons FTD...
Biochem Soc Trans (2006) 34 (5): 749–753.
Published: 25 October 2006
...D.J. Moore Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex. Recent...
Biochem Soc Trans (2005) 33 (4): 586–590.
Published: 01 August 2005
...O.A. Ross; M.J. Farrer PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within...