..., but rather mitochondria are engulfed directly by lysosomes, mediating mitochondrial secretion. As FNZ results in parkinsonism, we propose that excessive mitolysosome exocytosis is the cause. Correspondence: Xingguo Liu ( liu_xingguo@gibh.ac.cn ) 27 9 2022 14 11 2022 25 11 2022 ©...

... Parkinsonism PKRN, POLG Mitochondrial repair Dopamine metabolism damaging Motor neurons ALS TDP43, MATR3 RNA metabolism Protein synthesis at distant sites Motor neurons/ pyramidal neurons FTD/ALS VCP Ubiquitin proteasome Protein degradation throughout large cell Pyramidal neurons FTD...

...D.J. Moore Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex. Recent...

...O.A. Ross; M.J. Farrer PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within...