... of an in vitro approach to programme hESCs into β-cells will depend on the ability, at least to a certain degree, to sequentially reproduce the individual steps that characterizes normal β-cell ontogenesis during fetal pancreatic development, including definitive endoderm from which all gastrointestinal organs...

...Bertrand Duvillié; Volodymyr Stetsyuk; Gaëlle Filhoulaud; Ghislaine Guillemain; Raphaël Scharfmann Understanding pancreatic development is important for at least three reasons: first, from a cognitive point of view, to understand the development of a complex organ, the pancreas; next, because...