... with Portland Press and the Biochemical Society under a transformative agreement with JISC. liver pancreas reprogramming transcription factor transdifferentiation The history of cell reprogramming, or the manipulation of cellular identity, spans a century of technological and conceptual...

... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 liver metaplasia pancreas reprogramming transdifferentiation The term ‘metaplasia’ refers to the irreversible conversion of one differentiated cell or tissue type into another and can arise in a number...

...Bertrand Duvillié; Volodymyr Stetsyuk; Gaëlle Filhoulaud; Ghislaine Guillemain; Raphaël Scharfmann Understanding pancreatic development is important for at least three reasons: first, from a cognitive point of view, to understand the development of a complex organ, the pancreas; next, because...

... regeneration diabetes glucose metabolism pancreas transgenic model Pancreatic β-cells constitute approx. 80% of the endocrine pancreas, within the so-called islets of Langerhans. The β-cell mass assumes the production and release of insulin in order to regulate blood glucose homoeostasis...

... g.rutter@imperial.ac.uk ). 9 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 β-cell diabetes insulin pancreas It has become increasingly clear in the last few years that pancreatic β-cell failure or destruction lies at the heart not only of Type 1...

... The Biochemical Society 2005 In the liver, but not in the pancreas, GK activity is regulated by a 68 kDa GKRP (GK regulatory protein), which inhibits GK competitively with respect to glucose [ 4 ]. The binding affinity of GKRP for GK is increased by fructose 6-phosphate and decreased by fructose 1-phosphate...