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Keywords: palmitoylation
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Articles
Biochem Soc Trans (2024) BST20231290.
Published: 02 May 2024
... on the amino acid side chain. Typically, the 16-carbon fatty acid palmitic acid is the most abundant and commonly used lipid during S -acylation and, as such, this modification is commonly referred to as palmitoylation [ 13–15 ]. However, we now know that the enzymes that mediate S -acylation can accommodate...
Articles
Biochem Soc Trans (2024) 52 (1): 41–53.
Published: 22 February 2024
...Kobina Essandoh; James P. Teuber; Matthew J. Brody Despite the well-established functions of protein palmitoylation in fundamental cellular processes, the roles of this reversible post-translational lipid modification in cardiomyocyte biology remain poorly studied. Palmitoylation is catalyzed...
Articles
Biochem Soc Trans (2020) 48 (2): 529–536.
Published: 02 April 2020
...: Piers A. Hemsley ( p.a.hemsley@dundee.ac.uk ) 22 1 2020 10 3 2020 11 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 palmitoylation plants S-acylation S-palmitoylation While protein S-acylation has been...
Articles
Biochem Soc Trans (2020) 48 (1): 281–290.
Published: 24 December 2019
...Niall J. Fraser; Jacqueline Howie; Krzysztof J. Wypijewski; William Fuller The post-translational modification protein S-acylation (commonly known as palmitoylation) plays a critical role in regulating a wide range of biological processes including cell growth, cardiac contractility, synaptic...
Articles
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( anirban.banerjee@nih.gov ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins Of all...
Articles
Biochem Soc Trans (2017) 45 (4): 923–928.
Published: 16 June 2017
... using palmitoyl-CoA as a donor, forming an acyl–enzyme intermediate. In the second step, palmitate is transferred to substrate proteins. Mutation of the cysteine in the DHHC motif blocks both autoacylation and transfer activities [ 7 , 8 ], whereas mutation of the first histidine blocks only the second...
Articles
Biochem Soc Trans (2017) 45 (3): 751–758.
Published: 15 June 2017
... enzymes. Correspondence: Luke H. Chamberlain ( luke.chamberlain@strath.ac.uk ) 1 2 2017 16 3 2017 17 3 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 palmitoylation S-acylation S-palmitoylation zDHHC enzymes...
Articles
Biochem Soc Trans (2017) 45 (2): 409–416.
Published: 13 April 2017
...Marilyn D. Resh Post-translational modification of proteins by attachment of palmitate serves as a mechanism to regulate protein localization and function in both normal and malignant cells. Given the essential role that palmitoylation plays in cancer cell signaling, approaches that target...
Articles
Biochem Soc Trans (2015) 43 (2): 193–198.
Published: 07 April 2015
...David T.S. Lin; Elizabeth Conibear Protein palmitoylation is a dynamic post-translational modification, where the 16-carbon fatty acid, palmitate, is added to cysteines of proteins to modulate protein sorting, targeting and signalling. Palmitate removal from proteins is mediated by acyl protein...
Articles
Biochem Soc Trans (2015) 43 (2): 222–228.
Published: 07 April 2015
...) was discovered independently by two groups in the early 1990s. Mundy and Warren [ 1 ] found CLIMP-63 as the most palmitoylated protein during mitosis. Schweizer et al. [ 2 ] identified CLIMP-63 as the antigen of monoclonal antibodies generated against a subcellular fraction enriched in Golgi membranes. Studies...
Articles
Biochem Soc Trans (2015) 43 (2): 240–245.
Published: 07 April 2015
..., activity and membrane binding. Proteome-scale discovery on Plasmodium falciparum schizonts has revealed a complement of more than 400 palmitoylated proteins, including those essential for host invasion and drug resistance. The wide regulatory affect on this species is endorsed by the presence of 12...
Articles
Biochem Soc Trans (2015) 43 (2): 205–210.
Published: 07 April 2015
..., the interactions between huntingtin (HTT) and huntingtin interacting protein 14 (HIP14 or DHHC17) and HIP14-like (DHHC13, a HIP14 orthologue), palmitoyl acyltransferases for HTT, are disturbed, resulting in reduced palmitoylation of HTT. Genetic ablation of either Hip14 or Hip14l recapitulates many features of HD...
Articles
Biochem Soc Trans (2015) 43 (2): 246–252.
Published: 07 April 2015
... compilation © 2015 Biochemical Society 2015 ghrelin O-acyltransferase (GOAT) hedgehog acyltransferase (HHAT) membrane-bound O-acyltransferases (MBOATs) octanoylation palmitoleoylation palmitoylation porcupine (PORCN) In 2000, Hoffmann [ 1 ] reported a family of multi-domain membrane...
Articles
Biochem Soc Trans (2015) 43 (2): 199–204.
Published: 07 April 2015
... at the plasma membrane is initiated, maintained and controlled. Protein palmitoylation, a common post-translational modification, regulates protein targeting to the plasma membrane. Such modified proteins are enriched in these specialized membrane domains. In this review, we focus on palmitoylation of PSD-95...
Articles
Biochem Soc Trans (2014) 42 (2): 388–394.
Published: 20 March 2014
... The Authors Journal compilation © 2014 Biochemical Society 2014 cell–cell signalling chemotaxis palmitoylation pollen tube guidance secretion semi- in vivo pollen tube secretome (SIV-PS) In the 2011 review of Kessler and Grossniklaus [ 1 ] entitled ‘She's the boss: signaling in pollen tube...
Includes: Supplementary data
Articles
Biochem Soc Trans (2013) 41 (1): 62–66.
Published: 29 January 2013
...Luke H. Chamberlain; Kimon Lemonidis; Maria Sanchez-Perez; Martin W. Werno; Oforiwa A. Gorleku; Jennifer Greaves Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins...
Articles
Biochem Soc Trans (2013) 41 (1): 84–88.
Published: 29 January 2013
...Mathieu Blanc; Sanja Blaskovic; F. Gisou van der Goot S-Palmitoylation, the only reversible post-translational lipid modification, confers unique biochemical and functional properties to proteins. Although it has long been known that viral proteins are palmitoylated, recent studies reveal...
Articles
Biochem Soc Trans (2013) 41 (1): 67–71.
Published: 29 January 2013
.... Thus the mechanisms that control channel surface expression and/or activity are important determinants of their (patho)physiological function. BK channels are S-acylated (palmitoylated) at two distinct sites within the N- and C-terminus of the pore-forming α-subunit. Palmitoylation of the N-terminus...
Articles
Biochem Soc Trans (2013) 41 (1): 72–78.
Published: 29 January 2013
...Gareth M. Thomas; Richard L. Huganir In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA ( N -methyl- D -aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering...
Articles
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Articles
Biochem Soc Trans (2013) 41 (1): 29–34.
Published: 29 January 2013
...Maurine E. Linder; Benjamin C. Jennings Protein S-palmitoylation is a reversible post-translational modification of proteins with fatty acids. In the last 5 years, improved proteomic methods have increased the number of proteins identified as substrates for palmitoylation from tens to hundreds...
Articles
Biochem Soc Trans (2013) 41 (1): 89–94.
Published: 29 January 2013
...Nataliya Gorinski; Evgeni Ponimaskin The covalent attachment of palmitic acid to one or more cysteine residues (S-palmitoylation) is a widespread modification of signalling proteins. With the finding that palmitoylation is a dynamic process, it is now widely accepted that repeated cycles...
Articles
Biochem Soc Trans (2013) 41 (1): 95–100.
Published: 29 January 2013
... regulation of the cardiac Na + pump is therefore crucial to match cardiac output to the physiological requirements of an organism. The cardiac pump is a multi-subunit enzyme, consisting of a catalytic α-subunit and regulatory β- and FXYD subunits. All three subunits may become palmitoylated, although...
Articles
Biochem Soc Trans (2013) 41 (1): 43–49.
Published: 29 January 2013
...Brent R. Martin Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory...
Articles
Biochem Soc Trans (2010) 38 (2): 522–524.
Published: 22 March 2010
... glimpses of how DHHC-substrate specificity might be achieved. 1 To whom correspondence should be addressed (email J.Greaves@ed.ac.uk ). 17 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cysteine DHHC protein membrane topology palmitoylation S...
Articles
Biochem Soc Trans (2010) 38 (1): 163–166.
Published: 19 January 2010
.... Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking...
Articles
Articles
Biochem Soc Trans (2007) 35 (3): 577–582.
Published: 22 May 2007
... in order to determine whether these cholesterol- and isoprenoid-mediated effects are mediated via BACE. amyloid β-peptide β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol farnesylation palmitoylation β-secretase The production of Aβ (amyloid β-peptide) and its...
Articles
Biochem Soc Trans (2005) 33 (5): 1091–1093.
Published: 26 October 2005
... of BACE. amyloid-β β-site amyloid precursor protein clearing enzyme (BACE) cerulenin dimer farnesylation palmitoylation A considerable amount of AD (Alzheimer's disease) research is focused upon the production of Aβ (amyloid β-protein) in AD by BACE [β-site APP (amyloid precursor protein...
Articles
Biochem Soc Trans (2003) 31 (1): 94–97.
Published: 01 February 2003
... affinity proteomics lipid effector membrane targeting palmitoylation Abbreviations used: Arf, ADP-ribosylation factor; NSF, N -ethylmaleimide-sensitive factor; PA, phosphatidic acid; PC, phosphatidylcholine; PDE, phosphodiesterase; PH, pleckstrin homology; PIP 2 , PtdIns(4,5) P 2 ; PKC...