... potentials, which is the first step in generation of most somatic sensations, including pain. The activation and inactivation of sensory ion channels is tightly regulated and modulated by a variety of mechanisms. Amongst such mechanisms is the regulation of sensory ion channel activity via direct molecular...

... modulated by extrasynaptic α 5 -GABA A receptors. Chronic pathological pain was under the regulation of spinal and cortical α 2 - (and α 3 -) GABA A receptors. Thus the relevance of the diversity of inhibitory GABA A receptor subtypes for the regulation of cognition, emotion and memory is increasingly being...

.... The event was attended by academics, postdoctoral and postgraduate researchers, scientists from industry and clinicians. The themes of this year's conference, neurodegeneration, neuroregeneration, pain, glial cell biology and psychopharmacology, were chosen for their reflection of areas of strength...

...Siún Burke; George D. Shorten Chronic post-surgical pain is a common, under-recognized and important clinical problem which affects millions of patients worldwide. It results from a series of neuroplastic changes associated most commonly with peripheral nerve injury at the time of surgery...

...D. Salvemini; T.M. Doyle; S. Cuzzocrea A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use...

... and pain. Pancreatic (trypsin I and II) and extrapancreatic (trypsin IV) trypsins, mast cell tryptase and coagulation factors VIIa and Xa cleave and activate PAR 2 . Proteases cleave PAR 2 to expose a tethered ligand that binds to the cleaved receptor. Despite this irreversible activation, PAR 2 signalling...