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Keywords: p85
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Articles
Biochem Soc Trans (2020) 48 (4): 1397–1417.
Published: 17 July 2020
... in human cancers. In addition to their canonical role as part of the PI3K holoenzyme, the class IA PI3K regulatory subunits undertake critical functions independent of PI3K. The PI3K regulatory subunits exist in excess over the p110 catalytic subunits and therefore free in the cell. p110-independent p85...
Articles
Biochem Soc Trans (2009) 37 (4): 615–626.
Published: 22 July 2009
... of the catalytic cycle of the enzymes. 1 To whom correspondence should be addressed (email rlw@mrc-lmb.cam.ac.uk ). 25 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer p85 p110 phosphoinositide 3-kinase (PI3K) phosphoinositide 3,4,5-trisphosphate...
Articles
Biochem Soc Trans (2007) 35 (2): 242–244.
Published: 20 March 2007
... to their constitutive activation in transformed cells. The present paper will discuss recent studies on the regulation of class I (p85/p110) PI3Ks, with a focus on the role of SH2 domains (Src homology 2 domains) in the p85 regulatory subunit in modulating PI3K activity. 3rd Focused Meeting on PI3K Signalling...
Articles
Biochem Soc Trans (2007) 35 (2): 186–187.
Published: 20 March 2007
... activates PI3K signalling by interacting with the p85 regulatory subunit of PI3K [ 6 ]. In vitro pull-down assays using purified recombinant proteins demonstrated that NS1 is able to bind directly and efficiently to the p85β subunit of PI3K, but not to the related p85α isoform [ 6 ]. The relative affinity...
Articles
Biochem Soc Trans (2007) 35 (2): 199–203.
Published: 20 March 2007
...B. Geering; P.R. Cutillas; B. Vanhaesebroeck Class IA PI3Ks (phosphoinositide 3-kinases) consist of a p110 catalytic subunit bound to one of five regulatory subunits, known as p85s. Under unstimulated conditions, p85 stabilizes the labile p110 protein, while inhibiting its catalytic activity...
Articles
Biochem Soc Trans (2004) 32 (2): 320–325.
Published: 01 April 2004
... consist of a cata- lytic subunit (p110 , p110 , p110 ) and a regulatory subunit (p85 , p55 , p50 , p85 , p55 ). The regulatory subunits are encoded by at least three genes: the p85 , p55 and p50 proteins are derived from a single gene by alternative splicing mechanisms, while distinct genes encode p85...