... in human cancers. In addition to their canonical role as part of the PI3K holoenzyme, the class IA PI3K regulatory subunits undertake critical functions independent of PI3K. The PI3K regulatory subunits exist in excess over the p110 catalytic subunits and therefore free in the cell. p110-independent p85...

... of the catalytic cycle of the enzymes. 1 To whom correspondence should be addressed (email rlw@mrc-lmb.cam.ac.uk ). 25 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer p85 p110 phosphoinositide 3-kinase (PI3K) phosphoinositide 3,4,5-trisphosphate...

.... Akt antiviral drug influenza A virus NS1 protein phosphoinositide 3-kinase (PI3K) p85 © 2007 The Biochemical Society 2007 15 12 2006 1 To whom correspondence should be addressed (email bgh1@st-andrews.ac.uk ). Influenza A virus is a member of the Orthomyxoviridae...

...B. Geering; P.R. Cutillas; B. Vanhaesebroeck Class IA PI3Ks (phosphoinositide 3-kinases) consist of a p110 catalytic subunit bound to one of five regulatory subunits, known as p85s. Under unstimulated conditions, p85 stabilizes the labile p110 protein, while inhibiting its catalytic activity...

... to their constitutive activation in transformed cells. The present paper will discuss recent studies on the regulation of class I (p85/p110) PI3Ks, with a focus on the role of SH2 domains (Src homology 2 domains) in the p85 regulatory subunit in modulating PI3K activity. ABD adaptor-binding domain BCR...

... in Signalling and Disease, a Biochemical Society Focused Meeting held at Novartis Horsham Research Centre, U.K., 11–12 November 2003 22 October 2003 © 2004 Biochemical Society 2004 Bcl-xL Bruton's tyrosine kinase (Btk) nuclear factor-κB (NF-κB) p85 p110 Xid Abbreviations...